Abstract: The invention relates to an additive manufacturing method for producing a three-dimensional elastomer silicone article. The elastomer silicone article is built up layer by layer by printing a silicone composition crosslinkable by addition reactions comprising at least one organopolysiloxane-polyoxyalkylene copolymer with a 3D printer selected from an extrusion 3D printer or a material jetting 3D printer.

Abstract: Three-dimensional body implants including a hydrogel, which includes cross-linked alginate and gelatin, and in particular breast implants. The hydrogel of the implants has a mechanical strength of 1 kPa to 1000 kPa, and the hydrogel of the implants may further include fibrinogen. The implants include a porous zone, and the implants are acellular, i.e., free of cells during their manufacture.

Abstract: A bioink comprises a cell solution comprising living cells and a cell culture medium, and a self-assembling peptide solution comprising a self-assembling peptide. The bioink is formed by mixing and extruding the cell solution and the self-assembling peptide solution together, and the bioink can be continuously extruded from the mixer after mixing. Useful methods of making bioinks and are also disclosed.

Abstract: A jammed gel bioink comprises a self-assembling peptide solution comprising a self-assembling peptide, and a cell solution comprising living cells and a cell culture medium. The self-assembling peptide solution is extruded to form an object, and then the cell solution is injected into the object. Useful methods of making the jammed gel bioink are also disclosed.

Abstract: Methods for additive manufacturing include depositing a printing material in suspension within a printing tray containing a stressed medium, to form a three-dimensional object. This deposition of printing material is performed via at least one step of injecting the printing material using a nozzle of a printing head, which nozzle is immersed in the stressed medium and is able to move within the stressed medium in the three dimensions in space. This method comprises at least a step of modifying the level of the stressed medium in the printing tray. Additive manufacturing devices includes a stressed medium disposed in a printing tray, a printing head designed to dispense a printing material, and a device for modifying the level of the stressed medium of the printing tray. The printing head has a nozzle displaceable within the stressed medium in three spatial dimensions.

Abstract: The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40 wt. % gelatin; a second solution including between 15 and 35.wt. % alginate; a third solution including between 1 and 15 wt. % fibrinogen, and optionally living cells in suspension; and creating a mixture including: around 35 to 65 vol. % of the first solution; around 15 to 35 vol. % of the second solution; and around 15 to 35 vol. % of the third solution, said proportions being selected so that they add up to 100%. Said bio-ink allows the additive deposition of objects that can be polymerised by means of a solution including calcium ions and thrombin. Said objects can be incubated and can be used as a substitute for body tissue, for example (with added fibroblasts) as skin substitute.

Abstract: An additive manufacturing process and device implement the deposition of a material to form a three-dimensional object. The process includes depositing the material in suspension within a stressed granular medium that comprises a granular phase and a gaseous interstitial phase. The granular phase consists solely of a material taking the form of discrete, solid elements that interact in regions of contact therebetween.

Abstract: The present invention relates to a process for manufacturing a silicone elastomer article comprising the following step: 1) providing a composition C, comprising water and at least 20% by weight of at least one poloxamer, into a container; 2) placing the container comprising the composition C at the required temperature T1 to form a gel; 3) printing a crosslinkable silicone composition X into the gel obtained in 2) with a 3D printer at the required temperature T1; 4) optionally allowing the printed composition X to partially or totally crosslink, optionally by heating, to obtain a silicone elastomer article, into the container; 5) optionally placing the container obtained in step 4) at a temperature T3 lower than the sol-gel transition temperature of composition C; 6) recovering the silicone elastomer article; and 7) optionally washing the obtained silicone elastomer article for example with water at a temperature T3 lower than the sol-gel transition temperature of composition C.

Abstract: The invention relates to an additive manufacturing method for producing a three-dimensional elastomer silicone article. The elastomer silicone article is built up layer by layer by printing a silicone composition crosslinkable by addition reactions comprising at least one organopolysiloxane-polyoxyalkylene copolymer with a 3D printer selected from an extrusion 3D printer or a material jetting 3D printer.

Abstract: The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40 wt. % gelatin; a second solution including between 15 and 35 .wt. % alginate; a third solution including between 1 and 15 wt. % fibrinogen, and optionally living cells in suspension; and creating a mixture including: around 35 to 65 vol. % of the first solution; around 15 to 35 vol. % of the second solution; and around 15 to 35 vol. % of the third solution, said proportions being selected so that they add up to 100%. Said bio-ink allows the additive deposition of objects that can be polymerised by means of a solution including calcium ions and thrombin. Said objects can be incubated and can be used as a substitute for body tissue, for example (with added fibroblasts) as skin substitute.

Abstract: A complex including: a support provided with at least two faces one of which is provided with a coating of an adhesive, at least one ligand, said ligand being immobilized on the adhesive surface. The ligand implemented within the framework of the present invention is chosen from among proteins, peptides, antibodies, nucleic acids, sugars or oligosaccharides, toxins, pesticides, hormones, herbicides, fungicides, neurotransmitters.

Abstract: The invention concerns hybrid nanoparticles containing: a nanosphere, of mean diameter included in the range from 2 to 9 nm, of which at least 90% by weight consists of Ln2O3 where Ln represents a rare earth, optionally doped with a rare earth or an actinide, or a mixture of rare earths, or a rare earth and actinide mixture, in which at least 50% of the metal ions are rare earth ions, a coating around the nanosphere chiefly consisting of functionalized polysiloxane, having a mean thickness included in the range from 0.5 to 10 nm, preferably greater than 2 nm and no more than 10 nm, and at least one biological ligand grafted by covalent bonding to the polysiloxane coating and their method of preparation.

Abstract: The invention concerns hybrid nanoparticles containing: a nanosphere, of mean diameter included in the range from 2 to 9 nm, of which at least 90% by weight consists of Ln2O3 where Ln represents a rare earth, optionally doped with a rare earth or an actinide, or a mixture of rare earths, or a rare earth and actinide mixture, in which at least 50% of the metal ions are rare earth ions, a coating around the nanosphere chiefly consisting of functionalized polysiloxane, having a mean thickness included in the range from 0.5 to 10 nm, preferably greater than 2 nm and no more than 10 nm, and at least one biological ligand grafted by covalent bonding to the polysiloxane coating and their method of preparation.

Abstract: Hybrid probe particles comprising a nanoparticle of gold of diameter in the range extending from 2 to 30 nm on the surface of which, on the one hand, at least one, and preferably from one to 100, organic probe molecules are grafted by gold-sulphur bonds and on the other hand, at least 10, and preferably 10 to 10000, molecules with luminescent activity, as well as their preparation process.