Abstract: A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.

Abstract: Photoresponsive materials for use with a volumetric additive manufacturing system are described herein. Some embodiments of photoresponsive materials described herein include at least one constituent selected from the group consisting of (i) a thiol-containing siloxane prepolymer, (ii) a vinyl-containing siloxane prepolymer, (iii) a reinforcing filler, (iv) a photoinitiator (v) a polymerization inhibitor. Various methods of using the same photoresponsive materials in additive manufacturing processes, such as volumetric additive manufacturing, are also described.

Abstract: The invention relates to oblique transscleral illumination of an eye fundus with at least one physical point light source around the eye allowing for dark field imaging combined with optical coherence tomography imaging

Abstract: The invention discloses systems and methods for generation of microfluidic jets providing a tool for very precise and localized delivery of e.g., medicaments. The proposed solution overcomes shortcomings related to miniaturization of a jet injection technology by implementing laser energy as a driving mechanism and optical fibers for its delivery. Solving the step of miniaturization can allow building new tools compatible with minimally invasive surgical techniques, high parallelization of jet injection units or design of new ergonomic injection devices.

Abstract: The present invention describes an imaging system that allows visualization of a wide range of samples both in terms of morphology and in terms of material (e.g. density distribution, varying chemical composition, or anything that induces a change of optical path). The application of this imaging system includes absorptive samples as well as nearly and fully transparent samples with respect to the wavelength of illumination. Two elements are key in this system: the use of a so-called lock-in camera, and the synchronization of the recording to a modulation of choice along the image forming apparatus. Such modulation can consist for example in modulation of the illumination, use of filters, tilt/rotation of the sample or of certain microscope components.

Abstract: The invention discloses a system and method to obtain a set of corrected projected patterns from an integrated 3D measurement system so that the solidification of the formed object appears at the same time in a volumetric printer such as a tomographic back-projection or multi-beam printer, hence ensuring that the object is formed with the highest fidelity and spatial resolution.

Abstract: The present invention is related to a method of digitally compensating distortions of rays of a light beam in tomography-based additive manufacturing, wherein said tomography-based additive manufacturing involves projecting light patterns from multiple angles into a container (22) comprising photoresponsive material, by simulating the path of the light rays through the container (22) and the photoresponsive material; and digitally compensating the light projections based on the simulated path of the light rays, so as to obtain modified light projections. The present invention is also related to a method and apparatus for preparing an object (24) in tomography-based additive manufacturing, employing said distortion compensation method.

Abstract: A method for producing a three-dimensional object comprising computing a sequence of back-projections describing the three-dimensional object to be formed from different orientation angles of the object, defining a sequence of patterns of light using the back-projections, and irradiating with each of the patterns of light at the respective corresponding orientation angle. According to the defined sequence, a photoresponsive material is capable of altering its material phase, upon irradiation by light, thereby creating a three-dimensional distribution of alterations within the photoresponsive medium which physically reproduces the three-dimensional object, thereby creating the three-dimensional object.

Abstract: The present invention is related to a method and apparatus for the volumetric fabrication of three-dimensional objects or articles from photoresponsive materials loaded with scattering particles, by adjusting the refractive index of said photoresponsive material (12) so as to match the refractive index of said scattering particles (30), and/or using a light source emitting light of a wavelength longer than 630 nm, preferably in a range from 630 nm to 1050 nm, more preferably in a range from 650 nm to 900 nm.

Abstract: An ophthalmic illumination and imaging system with transscleral/transpalpebral illumination of the eye fundus comprises a light-delivering device with a plurality of emitting areas; each of the emitting areas being configured to be independently controllable and directed towards the sclera of the intended eye to measure, providing transscleral oblique illumination of the eye fundus; an active eye aberration correcting system; and an imaging system configured to create multiple images of the eye fundus on multiple imaging sensors.

Abstract: A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.

Abstract: The invention relates to a cross-linkable polymer including a base polymer including functional groups at least some of which have been reacted with a first organic molecule including a cross-linkable unit and with a second organic molecule capable of bonding to organic and/or inorganic substrates. The invention further relates to a hydrogel including the cross-linkable polymer that includes cross-linkable polymer strands, wherein at least some of the cross-linkable units of different cross-linkable polymer strands have reacted to form a covalent bond thereby forming a covalently linked network. The invention further relates to a method for the preparation of the hydrogel and to the use of the hydrogel.

Abstract: A method of fabricating a three-dimensional article comprises providing a spatially coherent light source (101, 201), generating from the light source (101, 201), patterns of light based on computed tomographic projections of the three-dimensional article, and projecting the patterns of light into a photoresponsive medium. The projecting is configured to define a three-dimensional dose distribution, thereby locally altering the phase of the photoresponsive medium and creating the article.

Abstract: Photoresponsive materials for use with a volumetric additive manufacturing system are described herein. Some embodiments of photoresponsive materials described herein include at least one constituent selected from the group consisting of (i) a thiol-containing siloxane prepolymer, (ii) a vinyl-containing siloxane prepolymer, (iii) a reinforcing filler, (iv) a photoinitiator (v) a polymerization inhibitor. Various methods of using the same photoresponsive materials in additive manufacturing processes, such as volumetric additive manufacturing, are also described.

Abstract: A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.

Abstract: A method for generating a three-dimensional patterned soft structure, including the steps of providing a soft supporting substrate, providing a drop-on-demand system with a device for varying the velocity of the jetted droplets, providing a liquid ink, jetting the liquid ink towards the soft supporting substrate with the drop-on-demand system, controlling an injection depth of the liquid ink into the soft supporting substrate by varying a jetting velocity of the liquid ink; and depositing droplets of the liquid ink over a volume of the soft supporting substrate, thereby generating the three-dimensional patterned soft structure.

Abstract: The present invention concerns an organic cavity injection device including an injection cannula for injecting a photo-activatable substance inside an organic cavity; at least one element or a plurality of elements configured to control the removal of a resident substance from the organic cavity and simultaneously prevent removal of the non-activated photo-activatable substance from the organic cavity; and an optical waveguide for providing electromagnetic radiation inside the organic cavity to the photo-activatable substance to photoactive the photo-activatable substance inside the organic cavity.

Abstract: A retinal projector system, comprising a coupling means, a spacial light modulator, and a tapered optical waveguide having an input side surface and an output side surface, whereby the input side surface is larger than the output side surface, the coupling means being configured to couple coherent light into the spatial light modulator, the spacial light modulator being configured to receive the coherent light and output modulated light modulated in 2 dimensions towards the input side surface, the tapered optical waveguide being configured to guide the modulated light received at the input side surface and reduce a size of the tapered optical waveguide towards the output side surface, without losing any information from the modulated light at the output side surface such to allow an image formation.

Abstract: A method for producing a three-dimensional object comprising computing a sequence of back-projections describing the three-dimensional object to be formed from different orientation angles of the object, defining a sequence of patterns of light using the back-projections, and irradiating with each of the patterns of light at the respective corresponding orientation angle. According to the defined sequence, a photoresponsive material is capable of altering its material phase, upon irradiation by light, thereby creating a three-dimensional distribution of alterations within the photoresponsive medium which physically reproduces the three-dimensional object, thereby creating the three-dimensional object.

Abstract: Disclosed herein are devices and methods to provide a holographic optical element (HOE) having a modified shape and a structural attribute. At least one wavefront may be used to cause a first structure change in a material, used for the HOE, in a first shape. The material used for the HOE may be changed from the first shape to the modified shape to cause a second structure change in the material. The structural attribute in the material may be provided from a combination of the first structure change and the second structure change.