Abstract: An electronic gaming system is described. The electronic gaming system includes a management server including a processor and a memory device storing computer-readable instructions. The instructions, when executed by the processor, cause the processor to receive player identification data and game data. The instructions also cause the processor to request and receive, based upon the player identification data and from a player tracking server, player data associated with the player account, cause display, on a host device associated with a casino host, of at least a portion of the player data and the game data, and determine that the EGM should be disabled for a predetermined amount of time. The instructions further cause the processor to cause display of a message indicating that the EGM will be disabled and disable the EGM for the predetermined amount of time.

Abstract: An electric pushback vehicle includes a frame having a forward portion and a rear portion. The vehicle further includes front drive axle and a rear drive axle configured to communicate power to ground engaging members. A traction battery is housed within the electric pushback vehicle and provides electric power to an electric motor to drive an output shaft. A transmission is connected to receive mechanical power from the electric motor through a torque converter.

Abstract: Provided by the inventive concept is a DNA methylation-based platform, and machine learning algorithms, for diagnosing respiratory pathogens including SARS-CoV-2 and predicting COVID-19 related outcomes, and methods of using the same, such as in identifying the presence of a viral infection, such as a SARS-CoV-2 infection, determining whether a subject has COVID-19, and/or whether a subject with COVID-19 is likely to develop acute respiratory distress syndrome or multisystem inflammatory syndrome in children.

Abstract: Disclosed herein are systems, pads, and methods thereof for targeted temperature management. A system, for example, can include a control module and a pad. The pad can include a multilayered pad body and one or more comfort-enhancing features integrated into the pad for mitigating or eliminating skin irritation along at least edges of the pad. The multilayered pad body can include a conduit layer, an impermeable film over the conduit layer, and an adherable layer over the impermeable film. The conduit layer can include one or more conduits configured to convey a fluid through the conduit layer. The impermeable film can be configured to retain the fluid in the conduit layer when the fluid is conveyed through the conduit layer. The adherable layer can be configured to adhere to a body portion of a patient. Methods of the systems and pads can include methods of use.

Abstract: A bearing and/or seal assembly where pressurized gas (e.g., air) may be arranged to produce a contact-free bearing and/or seal is provided. The assembly includes a permeable body (12) including structural features (13) selectively engineered to convey a pressurized gas (Ps) from an inlet side (20) side of the permeable body to an outlet side (22) of the permeable body to form an annular film of the pressurized gas relative to the rotatable shaft. Disclosed embodiments may be produced by way of three-dimensional (3D) Printing/Additive Manufacturing (AM) technologies with practically no manufacturing variability; and may also cost-effectively and reliably benefit from the relatively complex geometries and the features and/or conduits that may be involved to, for example, form the desired distribution pattern or impart a desired directionality to the pressurized gas conveyed through the permeable body of the bearing and/or seal assembly.

Abstract: Described herein are crystalline composition, methods of making such crystalline composition, pharmaceutical compositions and medicaments comprising such crystalline composition, and methods of using such crystalline composition in the treatment of conditions, diseases, or disorders that would benefit from modulation of Corticotropin-releasing hormone receptor 1 (CRF1).

Abstract: Polycystic ovary syndrome (PCOS) is characterized by elevated levels of androgens, cysts in the ovaries, and irregular periods. Women with PCOS present with additional symptoms, including hirsutism, alopecia, acne, infertility, weight gain, fatigue, depression and mood changes. The present disclosure provides new compounds, salts, compositions and uses thereof in the treatment of PCOS due to elevated adrenal androgens. Further, the present disclosure provides methods for treating PCOS due to elevated adrenal androgens.

Abstract: In one aspect a method that includes receiving an input signal captured by one or more first sensors associated with an active noise reduction (ANR) device, and processing the input signal using a first filter disposed in an ANR signal path to generate a first signal for an acoustic transducer of the ANR device. The input signal is processed in a pass-through signal path disposed in parallel with the ANR signal path to generate a second signal for the acoustic transducer, wherein the pass-through signal path allows a portion of the input signal to pass through to the acoustic transducer in accordance with a variable gain. One or more second sensors detect an existence of a condition likely to cause instability in the pass-through signal path, and in response, the variable gain is adjusted. A driver signal for the acoustic transducer is generated using an output based on the adjusted gain.

Abstract: Polycystic ovary syndrome (PCOS) is characterized by elevated levels of androgens, cysts in the ovaries, and irregular periods. Women with PCOS present with additional symptoms, including hirsutism, alopecia, acne, infertility, weight gain, fatigue, depression and mood changes. The present disclosure provides new compounds, salts, compositions and uses thereof in the treatment of PCOS due to elevated adrenal androgens. Further, the present disclosure provides methods for treating PCOS due to elevated adrenal androgens.

Abstract: Polycystic ovary syndrome (PCOS) is characterized by elevated levels of androgens, cysts in the ovaries, and irregular periods. Women with PCOS present with additional symptoms, including hirsutism, alopecia, acne, infertility, weight gain, fatigue, depression and mood changes. The present disclosure provides new compounds, salts, compositions and uses thereof in the treatment of PCOS due to elevated adrenal androgens. Further, the present disclosure provides methods for treating PCOS due to elevated adrenal androgens.

Abstract: Described herein are crystalline composition comprising a Corticotropin-releasing hormone receptor 1 (CRF1) antagonist, such as Compound 1: methods of making such crystalline composition, pharmaceutical compositions and medicaments comprising such crystalline composition, and methods of using such crystalline composition in the treatment of conditions, diseases, or disorders that would benefit from modulation of CRF.

Abstract: Described herein are crystalline composition comprising a Corticotropin-releasing hormone receptor 1 (CRF1) antagonist, such as Compound 1: methods of making such crystalline composition, pharmaceutical compositions and medicaments comprising such crystallin composition, and methods of using such crystalline composition in the treatment of conditions, diseases, or disorders that would benefit from modulation of CRF.

Abstract: In one aspect a method that includes receiving an input signal captured by one or more first sensors associated with an active noise reduction (ANR) device, and processing the input signal using a first filter disposed in an ANR signal path to generate a first signal for an acoustic transducer of the ANR device. The input signal is processed in a pass-through signal path disposed in parallel with the ANR signal path to generate a second signal for the acoustic transducer, wherein the pass-through signal path allows a portion of the input signal to pass through to the acoustic transducer in accordance with a variable gain. One or more second sensors detect an existence of a condition likely to cause instability in the pass-through signal path, and in response, the variable gain is adjusted. A driver signal for the acoustic transducer is generated using an output based on the adjusted gain.

Abstract: A computing system receives decrypts learned parameters of a computer-implemented predictive model stored in a computer-readable, non-volatile data store upon instantiation of a model process in volatile memory of the computing system. The predictive model is parameterized by learned parameters that are based upon private data of a user, wherein the learned parameters of the predictive model have been encrypted subsequent to training of the predictive model based upon the private data of the user. The computing system receives a request for a prediction associated with the user. Upon authorizing the request, the computing identifies the predictive model. The computing system, by way of the model process, generates the prediction based upon the request and the predictive model. The computing system outputs the prediction to a computing device associated with the user.

Abstract: The present disclosure provides an in vitro mammalian cell that is genetically modified to provide for enhanced production of adeno-associated virus (AAV) virions. The mammalian cells can be used to produce AAV virions, e.g., recombinant AAV virions that include a heterologous nucleic acid encoding a gene product; the present disclosure thus provides methods for producing an AAV virion, which may be a recombinant AAV virion.

Abstract: Patients with congenital adrenal hyperplasia (CAH) need adequate care and treatment in order to lead normal lives. Hence, there is a need for new methods of treating CAH. This disclosure provides new compounds, salts, compositions and uses thereof in the treatment of CAH.

Abstract: Techniques for efficient medical appointment scheduling are described. In an example, a method of facilitating access between a patient endpoint system and a healthcare provider computer system includes: receiving, at a management computer system through a network, healthcare provider information from the healthcare provider computer; storing the healthcare provider information in a database along with a collection of healthcare provider information from a plurality of other healthcare provider computer systems, the healthcare provider information including appointment availability information; providing, from the management computer to the patient endpoint system, an interface to the database to retrieving the healthcare provider information; and providing, from the patient endpoint system to the healthcare provider computer system, a request for an appointment based on the appointment availability information retrieved by the patient endpoint system from the database.

Abstract: A computing system receives decrypts learned parameters of a computer-implemented predictive model stored in a computer-readable, non-volatile data store upon instantiation of a model process in volatile memory of the computing system. The predictive model is parameterized by learned parameters that are based upon private data of a user, wherein the learned parameters of the predictive model have been encrypted subsequent to training of the predictive model based upon the private data of the user. The computing system receives a request for a prediction associated with the user. Upon authorizing the request, the computing identifies the predictive model. The computing system, by way of the model process, generates the prediction based upon the request and the predictive model. The computing system outputs the prediction to a computing device associated with the user.

Abstract: Systems and methods are provided for use in implementing access controls to content blocks of a user profile associated with a user. One exemplary system includes an access engine configured to receive an access command from a user, via a communication device, to access the user profile. The access command includes a designation of at least one the content blocks for access by a provider, an identity of the provider, and a duration of the access. The access engine is configured to also modify a permission associated with the designated content block(s) in relation to the provider to permit the access by the provider, and to expose the content block(s) to the provider, thereby granting the access for the provider to the content block(s). The access engine is configured to further terminate the access of the provider to the content block(s) when the duration of the access expires.

Abstract: The present disclosure provides a gene delivery system comprising: a) an R2 retrotransposon R2 polypeptide, or a first nucleic acid comprising a nucleotide sequence encoding the R2 polypeptide; and b) a nucleic acid comprising a heterologous nucleotide sequence encoding one or more heterologous gene products, where the heterologous nucleotide sequence is flanked by an R2 retrotransposon 3? untranslated region (UTR) and an R2 retrotransposon 5? UTR, and where the heterologous nucleotide sequence has a length of at least 200 nucleotides. The present disclosure provides a method of delivering one or more gene products of interest to a eukaryotic cell, the method comprising contacting the cell with the gene delivery vehicle system.