Abstract: Airsoles or bladders for articles of footwear comprising multi-layered films are provided herein. In one aspect, the airsoles or bladders comprise a first sheet and a second sheet, wherein a first side of the first sheet faces a second side of the second sheet, wherein the first sheet and the second sheet are bonded together to form an internal cavity in a space between the first side of the first sheet and the second side of the second sheet, forming a bladder capable of retaining a gas in the internal cavity at a pressure above atmospheric pressure, at atmospheric pressure, or below atmospheric pressure; and wherein each of the first sheet and the second sheet comprise a multi-layered film comprising: a core region comprising at least 20 gas barrier layers and a plurality of elastomeric layers, wherein the gas-barrier layers alternate with the elastomeric layers.

Abstract: Aspects of the present disclosure relate to color compositions and methods of making a printed layer using the color composition as well as an article that can include the printed layer.

Abstract: A processor-implemented method for generating a default adapter for context switching includes analyzing a first neural network model and one or more adapters. The first neural network model is pre-trained and each of the adapters is configured with an architecture and parameters for performing a different downstream task of a set of downstream tasks. A default adapter is defined based on a capacity of the one or more adapters. The default adapter is applied to one or more layers of the first neural network model during a context switch to a replace one of the adapters for a different task. A graph corresponding to the first neural network model is unchanged.

Abstract: An electrical connector system includes a circuit card assembly that includes a host circuit board, an interposer, and a socket connector arranged in a circuit stack. The electrical connector system includes a cable assembly that has cables electrically connected to terminating ends of the interposer contacts. The electrical connector system includes a pluggable module having a mating end with a module circuit board mated with the socket contacts of the socket connector. The electrical connector system includes a loading mechanism operably coupled to the circuit card assembly operated to compress the socket contacts between the module circuit board and interposer contacts to create circuit paths between the module contacts and the interposer contacts through the socket contacts. The cables are electrically connected to the pluggable module through the interposer and the socket connector.

Abstract: Systems and methods are provided for smart audio segmentation using look-ahead based acousto-linguistic features. For example, systems and methods are provided for obtaining audio, processing the audio, identifying a potential segmentation boundary within the audio, and determining whether to generate a segment break at the potential segmentation boundary. One or more look-ahead words occurring after the potential segmentation boundary are identified, wherein an acoustic segmentation score and a language segmentation score associated with the potential segmentation boundary and the one or more look-ahead words are generated. Systems then either refrain from generating a segment break at the potential segmentation boundary or generate the segment break at the potential segmentation boundary based on the acoustic and/or language segmentation score at least meeting or exceeding a segmentation score threshold.

Abstract: Aspects of this disclosure are directed to techniques that enable efficient automated text-to-speech pronunciation editing for long form text documents. A computing device comprising a memory and a processor may be configured to perform the techniques. The memory may store a text document. The processor may process words in the text document to identify first candidate words that are predicted to be mispronounced during automated text-to-speech processing of the text document. The processor may next filter the first candidate words to remove one or more candidate words of the first candidate words and obtain second candidate words that have fewer candidate words than the first candidate words. The processor may then annotate the text document to obtain an annotated text document that identifies the second candidate words, and output at least a portion of the annotated text document that identifies at least one candidate word of the second candidate words.

Abstract: In comparison to conventional sequencing pileup algorithms, the process described herein generates sequencing pileups that contains additional information not typically reported by conventional algorithms while also consuming fewer computational resources (e.g., time, processing power, and memory). First, each of a FASTA reference genome and BAM sequence read files are converted to an internal representation. This enables the rapid iteration across nucleotide bases of the sequence reads to determine support characteristics that summarize information of nucleic acid molecules corresponding to positions across the reference genome. Next, the support characteristics of positions across the reference genome are stored through a memory allocation process that utilizes a first and a second temporary storage. This enables the convenient freeing of one temporary storage while the other temporary storage is being used.

Abstract: The present disclosure is directed to articles that have a surface comprising a polymeric material having a printed layer disposed thereon that is durable and flexible. Prior to formation of the printed layer, the surface of the article can comprise a first layer of a first composition disposed on a portion of the polymeric material. The first composition can include a dispersion of uncrosslinked polymers (e.g., a water-borne dispersion of uncrosslinked polymers). The printed layer can be included on an article of footwear, a component of footwear, apparel, a component of apparel, sporting equipment, or a component of sporting equipment.

Abstract: Methods and systems for sample contamination detection are disclosed. In particular, sample barcodes are utilized, wherein each sample barcode is assigned to a sample and ligated to fragments from the sample. The sample barcodes are used in conjunction with indices from sequencing libraries to accurately assign sequence reads to samples during multiplex sequencing. Molecule identifiers may also be utilized to aid in de-duping of sequence reads to precisely identify original NA fragments from a sample. Accordingly, in one or more embodiments, a sequencing method includes isolating DNA fragments in a sample, ligating the DNA fragments with unique molecule identifiers (UMIs), performing an amplification process resulting in amplicons, ligating a sample barcode onto the amplicons, and performing amplicon sequencing. The analytics system looks to whether indices are matched and whether a sample barcode matches to the pair of indices when identifying single-index or double-index hopping events.

Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.

Abstract: Described herein are methods and systems for detecting and/or distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-CdtB antibodies and/or anti-vinculin antibodies to detect IBS, distinguish IBS from IBD and/or celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.

Abstract: A mouth insert for treating nosebleeds includes a main body and a bite tab. The bite tab removably engages the main body and is configured to move up and/or down vertically in order to adjust the height of the device. The main body includes a horizontally extending elongated portion, a center portion extending downward from a bottom surface of the elongated portion, and the center portion has a narrower width than the horizontally extending elongated portion. The elongated portion of the main body is shaped and dimensioned to be inserted into a buccal cavity of a user's mouth and to fit behind the user's upper lip and in front of the user's upper gums, and the center portion is shaped and dimensioned to be positioned only in front of the user's upper front teeth.

Abstract: In comparison to conventional sequencing pileup algorithms, the process described herein generates sequencing pileups that contains additional information not typically reported by conventional algorithms while also consuming fewer computational resources (e.g., time, processing power, and memory). First, each of a FASTA reference genome and BAM sequence read files are converted to an internal representation. This enables the rapid iteration across nucleotide bases of the sequence reads to determine support characteristics that summarize information of nucleic acid molecules corresponding to positions across the reference genome. Next, the support characteristics of positions across the reference genome are stored through a memory allocation process that utilizes a first and a second temporary storage. This enables the convenient freeing of one temporary storage while the other temporary storage is being used.

Abstract: Methods and systems for detecting contaminated fragments in a biological sample for cancer classification are disclosed. The system identifies CpG-SNP contamination markers. The CpG-SNP contamination markers include at least one SNP that affects a CpG site. The CpG-SNP contamination markers may include additive CpG-SNP sites and/or subtractive CpG-SNP sites. Additive CpG-SNP sites include an SNP that creates a new CpG site. Subtractive CpG-SNP sites include an SNP that removes a preexisting CpG site. Hybrid sites may include additional sites. A multiple CpG-SNP contamination marker comprises two or more CpG-SNP sites. A CpG-SNP & indel contamination marker comprises at least one CpG-SNP site and an indel site. For a given sample, the system identifies contamination markers for which the sample is homozygous. The system determines fragments having a haplotype that is different from the homozygous haplotype of the sample to be contamination fragments.

Abstract: Described herein are methods and systems for detecting and/or distinguishing irritable bowel syndrome (IBS) from inflammatory bowel disease (IBD) and celiac disease. The methods and systems can utilize the detection of anti-CdtB antibodies and/or anti-vinculin antibodies to detect IBS, distinguish IBS from IBD and/or celiac disease. Further described are methods for selecting a therapy to treat IBS, IBD or celiac disease.

Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.

Abstract: A mouth insert for treating nosebleeds includes a main body and a bite tab. The bite tab removably engages the main body and is configured to move up and/or down vertically in order to adjust the height of the device. The main body includes a horizontally extending elongated portion, a center portion extending downward from a bottom surface of the elongated portion, and the center portion has a narrower width than the horizontally extending elongated portion. The elongated portion of the main body is shaped and dimensioned to be inserted into a buccal cavity of a user's mouth and to fit behind the user's upper lip and in front of the user's upper gums, and the center portion is shaped and dimensioned to be positioned only in front of the user's upper front teeth.

Abstract: The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.

Abstract: An allelic position variant calling method using a prior genotype probability at the allelic position is provided. A strand specific base count set in forward and reverse directions for the allelic position is obtained, using strand orientation and identity of a respective base at the allelic position in each respective nucleic acid fragment sequence that maps to the allelic position, where bases at the allelic position whose identity can be affected by conversion of cytosine to uracil do not contribute to the strand specific base count set. Respective forward and reverse strand conditional probabilities are computed for each candidate genotype for the allelic position using the strand specific base count set and sequencing error estimate. Likelihoods are computed using a combination of these conditional probabilities and the prior genotype probability. From this, a determination is made as to whether the likelihoods support a variant call at the allelic position.

Abstract: Systems and methods for determining consensus base calls in nucleic acid sequencing are provided. A sequencing dataset is obtained corresponding to a plurality of base reads for a first base position within a plurality of base positions of a target nucleic acid molecule. The sequencing dataset includes at least two features, for each base read of the plurality of base reads. The at least two features are selected from among the features: a nucleotide base, a read quality score, a strand identifier, a trinucleotide context of the base read, and a confidence score associated with the trinucleotide context. The sequencing dataset is transformed into a feature tensor representing a distribution of the plurality of features in the sequencing dataset. The feature tensor is assessed with a classifier to determine a consensus base call for the first base position. The consensus base call comprises a predicted nucleotide base.