Abstract: A system and method for processing multi-modal microscopy imaging data on small-scale computer architecture which avoids restrictive manufacturer data formats and APIs. The system and method leverage a web-based application made available to microscopy instrument control hardware by which direct visual output of the control hardware is captured and transmitted to an edge computing device for processing by one or more inference models in parallel to construct a composite hyperimage.

Abstract: Provided are devices for automated analysis of one or more samples in single or multi-well plates or vessels, wherein the process of automated analysis comprises automated flow, wherein the samples comprise liquid or particles in a sample vessel, and wherein the devices comprise an assembly of components that enable processing of a sample for analytical assessment by fluidic and/or particle based instruments. Automated flow may comprise systems for moving samples including vacuum systems, pressure-based systems, pneumatic systems, pumps, peristaltic pumps, diaphragms, or syringes. The devices may comprise an assembly of components that enable movement in X, Y, and Z dimensions, as well as switches, microfluidic tubing, well plate block, electronic pressure controllers, pneumatic or fluidic mixing devices, components for fluid handling, sampling vessels, and mechanical components for translating or transporting system components.

Abstract: A photoionization detector sensor equipped with a temperature compensating and output adjustable ultraviolet lamp driver for supplying an alternating current signal to the ultraviolet lamp effective to light the ultraviolet lamp with direct current supplied from both a first variable voltage supply circuit and a second temperature sensitive fixed voltage supply circuit, and method of standardizing output of the photoionization detector sensor by adjusting the voltage supplied to the driver by the first variable voltage supply circuit so that future reported values will more closely approximate actual values.

Abstract: A system and method for processing multi-modal microscopy imaging data on small-scale computer architecture which avoids restrictive manufacturer data formats and APIs. The system and method leverage a web-based application made available to microscopy instrument control hardware by which direct visual output of the control hardware is captured and transmitted to an edge computing device for processing by one or more inference models in parallel to construct a composite hyperimage.

Abstract: A photoionization detector comprised of a sensor having at least a collector electrode and a grounding electrode, a gas discharge lamp that ionizes molecules of interest to create ionized molecules and electrons, and an amplifier connected to the collector electrode. Each of the collector electrode and the grounding electrode include a feed-thru pin, an inner trace surrounding the feed-thru pin, an outer trace surrounding the inner trace, wherein the outer trace on each electrode is comprised of the same material, a channel between the inner trace and the outer trace, wherein the channel is comprised of a different material than the outer trace and the inner trace, and a bridge connecting the outer trace with the inner trace. The ionized molecules are collectable by a bias electrode and electrons are collectable by the collector electrode.

Abstract: A photoionization detector sensor equipped with a temperature compensating and output adjustable ultraviolet lamp driver for supplying an alternating current signal to the ultraviolet lamp effective to light the ultraviolet lamp with direct current supplied from both a first variable voltage supply circuit and a second temperature sensitive fixed voltage supply circuit, and method of standardizing output of the photoionization detector sensor by adjusting the voltage supplied to the driver by the first variable voltage supply circuit so that future reported values will more closely approximate actual values.

Abstract: A photoionization detector sensor equipped with an adjustable gain amplifier, and method of standardizing output of the photoionization detector sensor by adjusting the gain so that an actual test value expected to produce a known anticipated value matches the anticipated value.

Abstract: A photoionization detector comprised of a sensor having at least a collector electrode and a grounding electrode, a gas discharge lamp that ionizes molecules of interest to create ionized molecules and electrons, and an amplifier connected to the collector electrode. Each of the collector electrode and the grounding electrode include a feed-thru pin, an inner trace surrounding the feed-thru pin, an outer trace surrounding the inner trace, wherein the outer trace on each electrode is comprised of the same material, a channel between the inner trace and the outer trace, wherein the channel is comprised of a different material than the outer trace and the inner trace, and a bridge connecting the outer trace with the inner trace. The ionized molecules are collectable by a bias electrode and electrons are collectable by the collector electrode.

Abstract: A microfluidic chip configuration wherein injection occurs in an upwards vertical direction, and fluid vessels are located below the chip in order to minimize particle settling before and at the analysis portion of the chip's channels. The input and fluid flow up through the bottom of the chip, in one aspect using a manifold, which avoids orthogonal re-orientation of fluid dynamics. The contents of the vial are located below the chip and pumped upwards and vertically directly into the first channel of the chip. A long channel extends from the bottom of the chip to near the top of the chip. Then the channel takes a short horizontal turn that nearly negates any influence of cell settling due to gravity and zero flow velocity at the walls. The fluid is pumped up to a horizontal analysis portion that is the highest channel/fluidic point in the chip and thus close to the top of the chip, which results in clearer imaging.

Abstract: A system and method for processing multi-modal microscopy imaging data on small-scale computer architecture which avoids restrictive manufacturer data formats and APIs. The system and method leverage a web-based application made available to microscopy instrument control hardware by which direct visual output of the control hardware is captured and transmitted to an edge computing device for processing by one or more inference models in parallel to construct a composite hyperimage.

Abstract: A microfluidic chip configuration wherein injection occurs in an upwards vertical direction, and fluid vessels are located below the chip in order to minimize particle settling before and at the analysis portion of the chip's channels. The input and fluid flow up through the bottom of the chip, in one aspect using a manifold, which avoids orthogonal re-orientation of fluid dynamics. The contents of the vial are located below the chip and pumped upwards and vertically directly into the first channel of the chip. A long channel extends from the bottom of the chip to near the top of the chip. Then the channel takes a short horizontal turn that nearly negates any influence of cell settling due to gravity and zero flow velocity at the walls. The fluid is pumped up to a horizontal analysis portion that is the highest channel/fluidic point in the chip and thus close to the top of the chip, which results in clearer imaging.

Abstract: Provided are devices for automated analysis of one or more samples in single or multi-well plates or vessels, wherein the process of automated analysis comprises automated flow, wherein the samples comprise liquid or particles in a sample vessel, and wherein the devices comprise an assembly of components that enable processing of a sample for analytical assessment by fluidic and/or particle based instruments. Automated flow may comprise systems for moving samples including vacuum systems, pressure-based systems, pneumatic systems, pumps, peristaltic pumps, diaphragms, or syringes. The devices may comprise an assembly of components that enable movement in X, Y, and Z dimensions, as well as switches, microfluidic tubing, well plate block, electronic pressure controllers, pneumatic or fluidic mixing devices, components for fluid handling, sampling vessels, and mechanical components for translating or transporting system components.

Abstract: A microfluidic chip configuration wherein injection occurs in an upwards vertical direction, and fluid vessels are located below the chip in order to minimize particle settling before and at the analysis portion of the chip's channels. The input and fluid flow up through the bottom of the chip, in one aspect using a manifold, which avoids orthogonal re-orientation of fluid dynamics. The contents of the vial are located below the chip and pumped upwards and vertically directly into the first channel of the chip. A long channel extends from the bottom of the chip to near the top of the chip. Then the channel takes a short horizontal turn that nearly negates any influence of cell settling due to gravity and zero flow velocity at the walls. The fluid is pumped up to a horizontal analysis portion that is the highest channel/fluidic point in the chip and thus close to the top of the chip, which results in clearer imaging.

Abstract: Disclosed herein is a method of providing a structure having two electrodes connected by nanowires, exposing the structure to an analyte that can adsorb onto the nanowires, and passing an electrical current through the nanowires to heat the nanowires to desorb the analyte. Also disclosed herein is an apparatus having the above structure; a current source electrically connected to the electrodes, and a detector to detect the analyte.

Abstract: A microfluidic chip configuration wherein injection occurs in an upwards vertical direction, and fluid vessels are located below the chip in order to minimize particle settling before and at the analysis portion of the chip's channels. The input and fluid flow up through the bottom of the chip, in one aspect using a manifold, which avoids orthogonal re-orientation of fluid dynamics. The contents of the vial are located below the chip and pumped upwards and vertically directly into the first channel of the chip. A long channel extends from the bottom of the chip to near the top of the chip. Then the channel takes a short horizontal turn that nearly negates any influence of cell settling due to gravity and zero flow velocity at the walls. The fluid is pumped up to a horizontal analysis portion that is the highest channel/fluidic point in the chip and thus close to the top of the chip, which results in clearer imaging.

Abstract: Disclosed herein is a method of providing a structure having two electrodes connected by nanowires, exposing the structure to an analyte that can adsorb onto the nanowires, and passing an electrical current through the nanowires to heat the nanowires to desorb the analyte. Also disclosed herein is an apparatus having the above structure; a current source electrically connected to the electrodes, and a detector to detect the analyte.

Abstract: Disclosed herein is a method of providing a structure having two electrodes connected by nanowires, exposing the structure to an analyte that can adsorb onto the nanowires, and passing an electrical current through the nanowires to heat the nanowires to desorb the analyte. Also disclosed herein is an apparatus having the above structure; a current source electrically connected to the electrodes, and a detector to detect the analyte.

Abstract: Provided are devices for automated analysis of one or more samples in single or multi-well plates or vessels, wherein the process of automated analysis comprises automated flow, wherein the samples comprise liquid or particles in a sample vessel, and wherein the devices comprise an assembly of components that enable processing of a sample for analytical assessment by fluidic and/or particle based instruments. Automated flow may comprise systems for moving samples including vacuum systems, pressure-based systems, pneumatic systems, pumps, peristaltic pumps, diaphragms, or syringes. The devices may comprise an assembly of components that enable movement in X, Y, and Z dimensions, as well as switches, microfluidic tubing, well plate block, electronic pressure controllers, pneumatic or fluidic mixing devices, components for fluid handling, sampling vessels, and mechanical components for translating or transporting system components.

Abstract: A microfluidic chip configuration wherein injection occurs in an upwards vertical direction, and fluid vessels are located below the chip in order to minimize particle settling before and at the analysis portion of the chip's channels. The input and fluid flow up through the bottom of the chip, in one aspect using a manifold, which avoids orthogonal re-orientation of fluid dynamics. The contents of the vial are located below the chip and pumped upwards and vertically directly into the first channel of the chip. A long channel extends from the bottom of the chip to near the top of the chip. Then the channel takes a short horizontal turn that nearly negates any influence of cell settling due to gravity and zero flow velocity at the walls. The fluid is pumped up to a horizontal analysis portion that is the highest channel/fluidic point in the chip and thus close to the top of the chip, which results in clearer imaging.

Abstract: Disclosed herein is a structure having: a support, a plurality of nanowires perpendicular to the support, and an electrode in contact with a first end of each nanowire. Each nanowire has a second end in contact with the support. The electrode contains a plurality of perforations. The electrode contains a plurality of perforations. Also disclosed herein is a method of: providing the above support and nanowires; depositing a layer of a filler material that covers a portion of each nanowire and leaves a first end of each nanowire exposed; depositing a plurality of nanoparticles onto the filler material; depositing an electrode material on the nanoparticles, the ends of the nanowires, and any exposed filler material; and removing the nanoparticles and filler material to form an electrode in contact with the first end of each nanowire; wherein the electrode contains a plurality of perforations.