Patents by Inventor Christopher A. Flask

Christopher A. Flask has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Deuterated metabolic water precursor for detecting and treating diseased tissue
    Patent number: 10646594
    Abstract: A method of diagnosing a mitochondrial related disease in a subject includes administering a deuterated metabolic water precursor to the subject, measuring a rate of deuterated water formation in a sample region of the subject, and comparing the measured deuterated water formation in the sample region to a control value. A difference between the rate of deuterated water formation in the sample region compared to a control value is indicative of a mitochondrial related disease.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: May 12, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffrey L. Duerk, Christopher A. Flask, Gheorghe D. Mateescu
  • Chemical shift markers for improved wireless fiducial marker tracking
    Patent number: 9031634
    Abstract: A new and improved method for tracking and/or spatial localization of an invasive device in Magnetic Resonance Imaging (MRI) is provided. The invention includes providing an invasive device including a marker having a chemically shifted signal source with a resonant frequency different from the chemical species of the subject to be imaged, applying a pulse sequence, detecting the resulting RF magnetic resonance signals, and determining the 3D coordinates of the marker. The invention also includes generating scan planes and reconstructing an image from the detected signals to generate an image having the marker contrasted from the subject. The invasive device includes a marker having a chemically shifted signal source which has a resonant frequency different from the chemical species of the subject to be imaged for use in tracking the device during imaging.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: May 12, 2015
    Inventors: Christopher Flask, Jonathan Lewin, Daniel Elgort, Ken Pin Wang, Eddy Wong, Jeffrey Duerk
  • Nanoparticles based on gadolinium coordination polymers as highly sensitive T1 MRI contrast agents
    Patent number: 8940275
    Abstract: An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: January 27, 2015
    Assignees: Kent State University, Case Western Reserve University
    Inventors: Songping D. Huang, Yongxiu Li, James P. Basilion, Jihua Hao, Christopher Flask
  • NANOPARTICLES BASED ON GADOLIIUM COORDINATION POLYMERS AS HIGHLY SENSITIVE T1 MRI CONTRAST AGENTS
    Publication number: 20130209369
    Abstract: An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
    Type: Application
    Filed: September 8, 2011
    Publication date: August 15, 2013
    Applicant: Case Western Reserved University
    Inventors: Songping D. Huang, Yongxiu Li, James P. Basilion, Jihua Hao, Christopher Flask
  • DEUTERATED METABOLIC WATER PRECURSOR FOR DETECTING AND TREATING DISEASED TISSUE
    Publication number: 20100322865
    Abstract: A method of diagnosing a mitochondrial related disease in a subject includes administering a deuterated metabolic water precursor to the subject, measuring a rate of deuterated water formation in a sample region of the subject, and comparing the measured deuterated water formation in the sample region to a control value. A difference between the rate of deuterated water formation in the sample region compared to a control value is indicative of a mitochondrial related disease.
    Type: Application
    Filed: June 21, 2010
    Publication date: December 23, 2010
    Inventors: JEFFREY L. DUERK, CHRISTOPHER A. FLASK, GHEORGHE D. MATEESCU
  • Chemical Shift Markers for Improved Wireless Fiducial Marker Tracking
    Publication number: 20080221428
    Abstract: A new and improved method for tracking and/or spatial localization of an invasive device in Magnetic Resonance Imaging (MRI) is provided. The invention includes providing an invasive device including a marker having a chemically shifted signal source with a resonant frequency different from the chemical species of the subject to be imaged, applying a pulse sequence, detecting the resulting RF magnetic resonance signals, and determining the 3D coordinates of the marker. The invention also includes generating scan planes and reconstructing an image from the detected signals to generate an image having the marker contrasted from the subject. The invasive device includes a marker having a chemically shifted signal source which has a resonant frequency different from the chemical species of the subject to be imaged for use in tracking the device during imaging.
    Type: Application
    Filed: May 15, 2003
    Publication date: September 11, 2008
    Inventors: Christopher A. Flask, Jonathan S. Lewin, Daniel R. Elgort, Ken-Pin Hwang, Eddy Y. Wong, Jeffrey L. Duerk