Abstract: The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genetic alterations. In particular, a method is provided for that includes obtaining a set of sequence reads. The sequence reads each include a single molecule barcode (SMB) sequence that is a non-random oligonucleotide sequence. The method further includes assigning the sequence reads to read groups according to a read group signature. The read group signature comprises an SMB sequence and a start and end position of a nucleic acid fragment from the circulating cell free sample nucleic acid. The sequence reads comprising start and end positions and an SMB sequence similar to the read group signature are assigned to a read group. The method further includes generating a consensus for each read group, and determining the presence or absence of a genetic alteration based on the consensus for each read group.

Abstract: An implantable radiating structure includes a directly excited element (“DEE”) that includes a top portion, a gap portion, and a bottom portion. The gap portion is between the top portion and the bottom portion. The top portion is coupled to the bottom portion via a connector, and the top portion, the gap portion, and the bottom portion of the DEE are planar. The implantable radiating structure also includes an indirectly excited element (“IEE”) radiatively coupled to the DEE. The IEE is positioned at an angle with respect to the DEE, and the DEE is orthogonal to the IEE. Further, the implantable radiating structure is configured to be implanted inside a human body and includes a bandwidth of at least 150 megahertz and a voltage standing wave ratio of approximately 2.

Abstract: Techniques and apparatus for evaluating analytical device performance and data quality are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to generate an analysis method to be performed by an analytical device, the analysis method comprising a plurality of method segments comprising at least one performance assessment process and at least one sample analysis process, and link the at least one performance assessment process with the at least one sample analysis process. Other embodiments are described.

Abstract: Techniques and apparatus for evaluating analytical device performance and data quality are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to generate an analysis method to be performed by an analytical device, the analysis method comprising a plurality of method segments comprising at least one performance assessment process and at least one sample analysis process, and link the at least one performance assessment process with the at least one sample analysis process. Other embodiments are described.

Abstract: Herein, a display device, system and method are described for identifying digital content through comparison of one or more audio thumbnails when the digital content is provided without metadata. According to one embodiment, a display device comprises a display, audio conversion logic and a transceiver. The audio conversion logic is adapted to produce one or more audio thumbnails, which are compact representations of a snippet of audio from that incoming digital content without the metadata. The transceiver is adapted to transmit the one or more audio thumbnails in order to (i) retrieve metadata associated with the digital content from an external source separate from a source of the digital content and (ii) display information provided by the metadata on the display.

Abstract: A fuser heater within a printing device includes a substrate with conductive traces and a resistive trace having a first end and a second end. The resistive trace is connected to the conductive traces at each of the first end and the second end and forms an electrical connection between the conductive traces and the resistive trace. A first strip is printed on the substrate using a first metal ink. A second strip is printed on the substrate using a second metal ink. The second strip is in contact with the first strip. The first metal ink is different from the second metal ink. The first strip and the second strip form a thermocouple. The thermocouple is operatively attached to the conductive traces. A controller operatively attached to the thermocouple controls the temperature of the fuser heater.

Abstract: An improved fuser includes a heater which provides uniformity at the surface of a fuser roll that contacts an imaged sheet. The heater is configured to include a common tap at the center of a single heating trace. This allows for the benefits of a single trace configuration well while simultaneously providing a dedicated common line that does not have to be switched around.

Abstract: An improved fuser includes a heater which provides uniformity at the surface of a fuser roll that contacts an imaged sheet. The heater is configured to include a new heating element consisting of a resistive trace flanked by conductive paths on either side in the process direction. On one end of the resistive trace is a single continuous conductive trace referred to as the common. On the other end resistive trace are three or more separate conductive traces to allow heating for different paper widths.

Abstract: Accordingly, an improved fuser is disclosed that includes a heater which provides uniformity at the surface of the fuser that contacts an imaged sheet by configuring a new heating element consisting of a resistive trace flanked by conductive paths on either side in the process direction. On one end of the resistive trace is a single continuous conductive trace referred to as the common. On the other end resistive trace are three or more separate conductive traces to allow heating for different paper widths. The resistive trace is augmented with dielectric circles to increase the overall resistivity of the heating element. Rows of dielectric can be offset from one another to insure overall thermal uniformity.

Abstract: A fuser heater within a printing device includes a substrate with conductive traces and a resistive trace having a first end and a second end. The resistive trace is connected to the conductive traces at each of the first end and the second end and forms an electrical connection between the conductive traces and the resistive trace. A first strip is printed on the substrate using a first metal ink. A second strip is printed on the substrate using a second metal ink. The second strip is in contact with the first strip. The first metal ink is different from the second metal ink. The first strip and the second strip form a thermocouple. The thermocouple is operatively attached to the conductive traces. A controller operatively attached to the thermocouple controls the temperature of the fuser heater.

Abstract: A system and method are provided for employing a unique optical roll scanning technique, scheme or process for detecting and identifying periodic surface defects associated with rolls usable in image production devices. An apparatus is provided for mounting the roll to implement an inspection technique that facilitates forming an image of a surface of the roll by rotating the roll through an entire cycle above a full width scanner device. The formed image of the surface of the scanned roll is filtered and analyzed particularly by applying a Fourier analysis technique, and/or by subjecting the filtered image data to a series of fast Fourier transforms (FFTs), potentially including 2D FFTs. The analysis process allows detected periodic defects in the formed image of the surface of the roll under analysis to be characterized by a magnitude of a response in a spatial frequency domain.

Abstract: A system and method are provided for employing a unique optical roll scanning technique, scheme or process for detecting and identifying periodic surface defects associated with rolls usable in image production devices. An apparatus is provided for mounting the roll to implement an inspection technique that facilitates forming an image of a surface of the roll by rotating the roll through an entire cycle above a full width scanner device. The formed image of the surface of the scanned roll is filtered and analyzed particularly by applying a Fourier analysis technique, and/or by subjecting the filtered image data to a series of fast Fourier transforms (FFTs), potentially including 2D FFTs. The analysis process allows detected periodic defects in the formed image of the surface of the roll under analysis to be characterized by a magnitude of a response in a spatial frequency domain.

Abstract: A self-contained, hand-held paint spray gun apparatus having a paint reservoir on the gun and a turret assembly having a reversible tip for spraying paint from the reservoir through the tip and a swirl chamber adapter located between the gun and turret assembly. The tip is reversible between a SPRAY position and a CLEAN position to enable a user of the paint spray gun to rapidly and conveniently clear an obstruction in the tip and continue spraying without removing the tip. The swirl chamber adapter has a generally planar face opposing a swirl valve in the gun and forming a swirl chamber upstream of the turret assembly and has a centrally located bore extending from the generally planar face to the outlet of the adapter.

Abstract: Methods include moving a fuser assembly with respect to a medium at a fusing nip. The fuser assembly may be moved back and forth, axially in a media cross process direction for registration distribution. The system may be configured to move the fuser assembly different distances based on a deduction of a current location of a fuser member in view of a known driving motor speed, and a time elapsed after a change in signal state. Systems may incorporate one or two sensors, and may be configured for axial movement over a distance of 2 mm or a distance of 55 mm. signature.

Abstract: A television and camcorder combination include an acoustic echo canceller and a videoconference protocol stack in order to provide videoconferencing capabilities using only a television in combination with an attached camcorder. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: A method of processing a boot sequence for a processor forming a part of a module apparatus involves interrogating a host television device to determine if the host television device requires use of an application execution engine residing on the module apparatus; receiving a reply to the interrogation; and responsive to the reply, establishing a mode of operation wherein the application execution engine is used to execute application code for the host television device. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: A DRM disk such as a Blu-ray stores content in a high resolution version for playing by a disk player. The disk also stores the same content in a lower resolution version for playing by a secondary device such as a Playstation Portable (PSP). The disk can be engaged with the disk player and the lower resolution format transferred to the secondary player through a mechanism such as a removable medium (e.g., a Sony Memory Stick®) or a USB connection or other means in accordance with DRM restrictions on the disk.

Abstract: A method of processing a boot sequence for a processor forming a part of a module apparatus involves interrogating a host television device to determine if the host television device requires use of an application execution engine residing on the module apparatus; receiving a reply to the interrogation; and responsive to the reply, establishing a mode of operation wherein the application execution engine is used to execute application code for the host television device. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: One embodiment relates to a computer method of evaluating proposed edits to a target layer of an integrated circuit. In the method, a number of editable regions is determined for metal layers overlying the target layer, where an editable region for a metal layer is laterally arranged between segments of the metal layer. The method identifies a number of possible vertical milling paths that extend from an exterior surface of the integrated surface to the target layer. Each possible vertical milling path passes through at least one editable region. The method generates a number of possible edit plans that are based on both the proposed edits and the number of possible vertical milling paths, where each edit plan places edits in a different combination of possible vertical milling paths.