Abstract: Two components of an aircraft structure are joined by providing a threaded opening in one of them and supporting an alignment insert in that opening. The alignment insert is used to guide drilling of the second component such that a hole is produced which is aligned with the threaded opening, for instance using an alignment projection which physically guides a drill. The alignment insert may then be removed. A fastener is then inserted through that hole and into the threaded opening, then tightened to form the completed joint.

Abstract: Aspects of the present invention relate to a valve seat (20) for a poppet valve of an internal combustion engine, wherein the poppet valve comprises a head and a stem behind the head, the valve seat comprising: an aperture (21) configured to form a seal with the head of the poppet valve when the poppet valve is in a closed position; and a peripheral body (22) defining, at least in part, one or more ports (23) shaped like e.g. grooves and sized to enable injection of liquid or gas from a cylinder head of the internal combustion engine into a gas stream behind the head of the poppet valve.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The disclosed playback devices, media playback systems, and/or methods improve upon the media playback experience by selectively reducing audio quality under certain conditions. The reduction of audio quality may be based on one or more aspects of the acoustic environment, such as the number and locations of one or more users, noise levels, playback device locations relative to the acoustic environment, etc. The media playback system may monitor or periodically poll each of one or more playback devices and other devices or sensors in and around an acoustic environment to determine whether there are opportunities to reduce audio quality for one or more playback devices. This reduction in quality allows the media playback system to conserve resources in one or more aspects and, potentially, divert those resources to other aspects for purposes.

Abstract: The present invention relates to compounds which are useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their application as pharmaceuticals for the treatment of disease.

Abstract: An apparatus relating to a component for a turbine engine which generates a hot gas fluid flow, and provides a cooling fluid flow. The component having a wall separating the hot gas fluid flow from the cooling fluid flow and having a heated surface along which the hot gas fluid flow flows and a cooled surface facing the cooling fluid flow. At least one cooling hole including a connecting passage extending from a first inlet located at the cooled surface, to a first outlet located at the heated surface, the connecting passage defining a downstream flow direction from the first inlet to the first outlet, the connecting passage comprising a metering section fluidly coupled to the first inlet and defining a metered centerline and a diffusing section, downstream of the metering section, defining a diffused centerline, and fluidly coupling the metering section to the first outlet.

Abstract: Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.

Abstract: An implantable medical device configured to provide for an intracardiac function, the implantable medical device comprises a body, a sensor arrangement arranged on the body and configured to receive cardiac sense signals, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process cardiac sense signals received using the sensor arrangement to detect a signal deflection potentially indicative of an atrial event caused by atrial activity to obtain an atrial detection, to detect a signal deflection indicative of a ventricular event caused by ventricular activity succeeding said atrial detection, to determine an atrial-ventricular interval representing a time between the atrial detection and the ventricular event, and to identify the atrial detection as valid or invalid based on the atrial-ventricular interval.

Abstract: An implantable medical device configured to provide for an intracardiac function comprises a body, a sensor arrangement arranged on the body and configured to receive a cardiac sense signal, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process the cardiac sense signal received using the sensor arrangement to detect, in a cardiac cycle, a first atrial event candidate based on a comparison of the cardiac sense signal with a sense threshold, to determine a modified sense threshold, to monitor, by comparing the cardiac sense signal to said modified sense threshold following the detection of the first atrial event candidate, whether in the same cardiac cycle a second atrial event candidate is detected.

Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.

Abstract: A label sheet includes a plurality of label assemblies. Each label assembly includes a label and a liner. The label includes a label first portion having an adhesive surface, and a label second portion having an adhesive surface. The liner includes a liner first portion coupled to the label first portion, the liner first portion configured to be separable from the label first portion, and a liner second portion coupled to the label second portion. A cut is formed in the liner and positioned between the liner first portion and the liner second portion. The cut includes a first curved portion positioned at a first edge of the liner and a second curved portion positioned at a second edge of the liner.

Abstract: Techniques for providing an adaptive approach to prefetching data for sequential read streams in a storage system. The techniques can include performing prefetch operations for a sequential read stream in accordance with a prefetch distance and a prefetch size, counting or otherwise keeping track of occurrences of failure scenarios in the prefetch operations while servicing the sequential read stream, and modifying or adjusting one of the prefetch distance and the prefetch size based on the occurrences of the respective failure scenarios. In this way, host input/output (IO) latency can be reduced, and IO bandwidth can be increased, in the servicing of sequential read streams by the storage system.

Abstract: Compositions and methods for genetically modifying at least one nucleic acid sequence of interest in a polyploid organism.

Abstract: The technology disclosed relates to systems and methods for generating a multi-part place identifier with at least one part. The system includes logic to receive a location address and a place name wherein the location address is a validated address. The system includes logic to calculate a geocode for the location address and use the geocode to identify a geometrical boundary encompassing the location address. The system includes logic to convert the identified geometrical boundary to an alpha-numeric identifier forming a Where part of the multi-part place identifier. The system can use an input location address or a place name to match a previously generated and stored multi-part place identifier. The system can provide the generated or matched multi-part place identifier to a user for use in further analysis.

Abstract: An implantable medical device configured to provide for an intracardiac function comprises a body, a sensor arrangement arranged on the body and configured to receive cardiac sense signals, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process cardiac sense signals received using the sensor arrangement to detect atrial events caused by atrial activity based on a comparison of the cardiac sense signals to a sense threshold for a number of cardiac cycles, to evaluate whether a reduction criterion is fulfilled, wherein the reduction criterion is fulfilled if in X1 out of Y1 cardiac cycles no atrial events have been detected, X1 being a natural number equal to or larger than 1 and Y1 being a natural number equal to or larger than X1, and to reduce the sense threshold if said reduction criterion is fulfilled.

Abstract: Provided are chimeric antigen receptors (CARs), which contain extracellular antigen-binding domains that bind to G Protein-Coupled Receptor Class C Group 5 Member D (GPRC5D) and B-cell maturation antigen (BCMA). The disclosure further relates to genetically engineered cells expressing such CARs, and uses thereof in adoptive cell therapy.

Abstract: An apparatus, system and method of for certifying a sensor that at least partially navigates an autonomous mobile robot. The apparatus may include at least a robot body; at least one light source resident on the robot body proximate to the sensing camera such that the at least one light source is capable of at least partially irradiating a field of view (FoV) of the sensing camera, wherein the at least one light source has characteristics substantially mated to the sensing camera; and at least one processing system that provides the at least partial navigation. The at least one processing system may execute the steps of: actuating the at least one light source at a predetermined time and for a predetermined duration; monitoring data from the sensing camera for confirmation of the actuating; calculating at least one of the latency, throughput, and reactivity of the sensing camera based on the monitoring; and at least partially navigating based on the calculating.

Abstract: A loudspeaker for hearing devices including a diaphragm arranged in a housing to form a back volume and a front volume acoustically coupled to a sound port is disclosed. A surface of a first magnet in the front volume faces an opposing surface of a second magnet in the back volume, and the opposing surfaces of the magnets are separated by a gap and have the same magnetic polarity. An electrical coil assembly coupled to the diaphragm has a radial difference dimension to thickness dimension ratio greater than 1, wherein the diaphragm and the electrical coil assembly are movable in the gap between the magnets in response to an electrical audio signal applied to the electrical coil assembly.

Abstract: An apparatus and method relating to a cooling hole of a component of a turbine engine. The component can include a wall separating the hot gas fluid flow from the cooling fluid flow and having a heated surface along which the hot gas fluid flow flows and a cooled surface facing the cooling fluid flow and at least one cooling hole comprising at least one inlet at the cooled surface, at least one outlet at the heated surface, with the outlet having a modified outlet shape.

Abstract: A combustor for a turbomachine engine includes a dome made of a ceramic matrix composite (CMC) material, the dome being secured within a support structure. The combustor includes an outer liner made of the CMC material, the outer liner being secured to the dome within the support structure. The combustor also includes an inner liner made of the CMC material, the inner liner being secured to the dome within the support structure.