Patents by Inventor Christopher A. Klug

Christopher A. Klug has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220003824
    Abstract: Disclosed herein is a method of: providing a circuit having: a rechargeable pouch cell battery comprising lithium and an electrically insulating coating, a first electrical lead in contact with the coating at a first location on the battery, a second electrical lead in contact with the coating at a second location on the battery, a tuning capacitor in parallel to the battery, and an impedance matching capacitor in series with the battery and the tuning capacitor; placing the battery in a magnetic field; applying a radio frequency voltage to the circuit; and detecting a 7Li nuclear magnetic resonance signal in response to the voltage.
    Type: Application
    Filed: July 1, 2021
    Publication date: January 6, 2022
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Christopher A. Klug, Stefan Benders, III, Mohadesse Mohammadi, Alexej Jerschow
  • Publication number: 20210405025
    Abstract: Provided herein is a method for identifying compounds that inhibit cell growth or have cytotoxic activity against cancer cells, such as hematological cancer cells or ovarian cancer cells, in a subject. Further provided is a method for identifying one or more compounds that sensitize refractory cancer cells from a subject. Also provided are compositions and methods for treating cancer, including refractory cancer, such as refractory acute myeloid leukemia (AML) or ovarian cancer.
    Type: Application
    Filed: June 14, 2019
    Publication date: December 30, 2021
    Applicant: THE UAB RESEARCH FOUNDATION
    Inventor: Christopher Klug
  • Patent number: 10775459
    Abstract: The invention relates to compounds known as “optorelaxers,” for example, spin crossover (SCO) complexes that exhibit light-induced excited state spin trapping (LIESST) effects with transient unpaired electron spins, which are created (or destroyed) by varying the level and/or wavelength of light to which the complexes are exposed. Light conditions are used to switch the optorelaxers between transient paramagnetic and diamagnetic states to provide real-time control of T1 relaxation in nuclear magnetic resonance (NMR) spectroscopy methods. The optorelaxers and methods of the invention provide increased detection sensitivity of NMR spectroscopy, with increased structural information content, while maintaining resolution for a wide variety of different NMR-active nuclei.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: September 15, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: James P. Yesinowski, Joel B. Miller, Christopher A. Klug
  • Publication number: 20200148632
    Abstract: Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily dissolve in water and buffer solutions. Synthesis of novel creatine salts using environmentally safe solvents such as ethanol resulted in the formation of products in quantitative yields with sodium or potassium chloride as a byproduct. The creatine and creatine alkyl eater derivative salts are stable sweet-tasting compounds that are more palatable to a consumer than creatine or derivatives thereof.
    Type: Application
    Filed: May 7, 2018
    Publication date: May 14, 2020
    Inventors: Iryna Lebedyeva, Christopher Klug
  • Publication number: 20140279178
    Abstract: The disclosed embodiment relates to connecting real-world vendors with customers through a virtual game environment using a computer-implemented method, an apparatus comprising one or more processors and one or more memories operatively coupled to at least one of the one or more processors, and at least one non-transitory computer-readable medium storing computer-readable instructions. An exemplary method includes receiving information from a user regarding a desired product or service, presenting a virtual game environment based at least in part on the desired product or service, monitoring the user's activity in the virtual game environment, providing an offer to the user corresponding to the desired product or service, the offer being based at least in part on the user's activity in the virtual game environment, and providing information identifying a real-world vendor corresponding to the offer, thereby enabling interactions between the user and the real-world vendor.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 18, 2014
    Applicant: EMERALD GAMES MARKETING LIMITED
    Inventors: Charles L. Harman, Gerard Christopher Klug
  • Publication number: 20140279259
    Abstract: The disclosed embodiments relate to connecting real-world vendors with customers through a virtual interface using a computer-implemented method executed by one or more computing devices, an apparatus comprising one or more processors and one or more memories operatively coupled to at least one of the one or more processors, and at least one non-transitory computer-readable medium storing computer-readable instructions. An exemplary method comprises receiving, through a virtual interface, information from a user regarding a desired product or service, providing, through the virtual interface, information to the user regarding one or more real-world vendors offering the desired product or service, and enabling interactions between the user and at least one of the one or more vendors offering the desired product or service through the virtual interface.
    Type: Application
    Filed: December 23, 2013
    Publication date: September 18, 2014
    Applicant: EMERALD GAMES MARKETING LIMITED
    Inventors: Charles L. Harman, Gerard Christopher Klug
  • Patent number: 7791342
    Abstract: A device for detecting a class of target species containing quadrupolar nuclei in a specimen by nuclear quadrupole resonance, comprising a pulse generator for generating a three-pulse-composite-pulse to refocus signals that were excited by another pulse, an irradiator for irradiating a specimen with the three-pulse-composite-pulse, a detector for detecting an NQR signal in response to irradiating the specimen, a coupler for transmitting the three-pulse-composite-pulse to the irradiating means, and a transformer for converting the free induction decay signal into a frequency domain signal. A method for detecting a class of target species containing quadrupolar nuclei in a specimen by nuclear quadrupole resonance, comprising generating a three-pulse-composite-pulse, irradiating said specimen with said three-pulse-composite-pulse, detecting an NQR signal in response to irradiating said specimen and converting said free induction decay signal into a frequency domain signal.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: September 7, 2010
    Inventors: Karen L. Sauer, Christopher A. Klug, Michael L. Bucss, Joel B. Miller
  • Publication number: 20090027049
    Abstract: A device for detecting a class of target species containing quadrupolar nuclei in a specimen by nuclear quadrupole resonance, comprising pulse generating means for generating a three-pulse-composite-pulse to refocus signals that were excited by another pulse, irradiating means for irradiating a specimen with the three-pulse-composite-pulse, detecting means for detecting an NQR signal in response to irradiating the specimen, coupling means for transmitting the three-pulse-composite-pulse to the irradiating means, coupling means for receiving the NQR signal from the detecting means and transform means for converting the free induction decay signal into a frequency domain signal.
    Type: Application
    Filed: May 16, 2008
    Publication date: January 29, 2009
    Inventors: Karen L. Sauer, Christopher A. Klug, Michael L. Bucss, Joel B. Miller
  • Publication number: 20060177929
    Abstract: Disclosed are methods for regulating the self-renewal capacity of stem cells such as, but not limited to, primitive hematopoietic stem cells (HSCs) (both mouse and human) by modulating the function and/or activity of target factors that are controlled or altered in their regulation by AML1-ETO expression in stem cells such as HSC. Target factors include, but are not limited to, AML1, C/EBP alpha, and/or PU.1 either individually, or in combinations, Altering the function and/or activity of such target factors in HSC leads to inhibition of HSC differentiation and stimulation of HSC self-renewal capacity. Modulation of target factor activity may be achieved at the level of synthesis of these target factors, interaction with cellular factors required for basal activity or enhanced activity, such as cofactors, interactions with their DNA binding motifs, or by targeted degradation or inhibition of their mRNAs.
    Type: Application
    Filed: March 22, 2004
    Publication date: August 10, 2006
    Inventor: Christopher Klug
  • Publication number: 20050030029
    Abstract: A magnetic resonance detection apparatus is provided that is not susceptible to acoustic ringing, and a method is provided for eliminating or canceling acoustic ringing from a detected magnetic resonance signal. Specifically, a composite pulse is utilized that allows for both efficient reduction of acoustic ringing signals and the detection of true NQR signals. The composite pulse can be used in any of the common NQR pulse sequences currently utilized simply via substitution of the original single pulses with the composite pulse. Furthermore, although a preferred application involves the spin-1 nucleus 14N and NQR, the composite pulse will be useful for the NQR of other nuclei such as 35Cl and 39K and in NMR applications and involving half-integer quadrupolar nuclei and spin-½ nuclei. In addition, coil ringdown and piezoelectric ringing are also substantially reduced.
    Type: Application
    Filed: August 8, 2003
    Publication date: February 10, 2005
    Inventors: Karen Sauer, Christopher Klug, Allen Garroway, Joel Miller
  • Patent number: H2177
    Abstract: A magnetic resonance detection apparatus is provided that is not susceptible to acoustic ringing, and a method is provided for eliminating or canceling acoustic ringing from a detected magnetic resonance signal. Specifically, a composite pulse is utilized that allows for both efficient reduction of acoustic ringing signals and the detection of true NQR signals. The composite pulse can be used in any of the common NQR pulse sequences currently utilized simply via substitution of the original single pulses with the composite pulse. Furthermore, although a preferred application involves the spin-1 nucleus 14N and NQR, the composite pulse will be useful for the NQR of other nuclei such as 35CI and 39K and in NMR applications and involving half-integer quadrupolar nuclei and spin- 1/2 nuclei. In addition, coil ringdown and piezoelectric ringing are also substantially reduced.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: January 2, 2007
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Karen L. Sauer, Christopher A. Klug, Allen Garroway, Joel B. Miller