Patents by Inventor Christopher A. Lepre

Christopher A. Lepre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying drug cores
    Publication number: 20030143757
    Abstract: The present invention relates to methods for detecting chemical moieties that may serve as the core or scaffold of a potential drug that is directed to a target. The invention further relates to a chemical library of drug cores and the use of that library to identify useful drug cores for a particular target protein.
    Type: Application
    Filed: October 25, 2002
    Publication date: July 31, 2003
    Inventors: Jonathan Moore, Guy William Bemis, Christopher A. Lepre, Jasna Fejzo, Jeffrey Weilee Peng, Keith Phillip Wilson, Mark Andrew Murcko
  • Inhibitors of bace
    Publication number: 20030095958
    Abstract: The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.
    Type: Application
    Filed: April 29, 2002
    Publication date: May 22, 2003
    Inventors: Govinda R. Bhisetti, Jeffrey O. Saunders, Mark A. Murcko, Christopher A. Lepre, Shawn D. Britt, Jon H. Come, David D. Deininger, Tianshang Wang
  • Process for identifying a solvent condition suitable for determining a biophysical property of a protein
    Patent number: 6056920
    Abstract: The present invention provides processes for identifying a buffer condition suitable for determining a biophysical property of a protein. The processes of this invention utilize vapor diffusion means to alter buffer conditions, thus minimizing the volume of test samples and thereby conserving protein material. The processes of this invention are particularly useful to determine a buffer condition suitable for performing NMR studies on a protein. The invention also provides a kit for performing the method.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: May 2, 2000
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: Christopher A. Lepre
  • Processes for identifying a solvent condition suitable for determining a biophysical property of a protein
    Patent number: 6057159
    Abstract: The present invention provides processes for identifying a buffer condition suitable for determining a biophysical property of a protein. The processes of this invention utilize vapor diffusion means to alter buffer conditions, thus minimizing the volume of test samples and thereby conserving protein material. The processes of this invention are particularly useful to determine a buffer condition suitable for performing NMR studies on a protein.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: May 2, 2000
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventor: Christopher A. Lepre