Abstract: Novel human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for IL-2R? receptor and a decreased binding capacity for IL-2R?c receptor, as compared to wild-type IL-2. Such IL-2 muteins are useful, for example, as IL-2 partial agonist and antagonists in applications where reduction or inhibition of one or more IL-2 and/or IL-15 functions is useful (e.g., in the treatment of graft versus host disease (GVHD) and adult T cell leukemia). Also provided are nucleic acids encoding such IL-2 muteins, methods of making such IL-2 muteins, pharmaceutical compositions that include such IL-2 muteins and methods of treatment using such pharmaceutical compositions.

Abstract: In a mobile device, a method of interacting with a first social networking website by way of a network includes communicating indirectly with the first social networking website by interacting with an intermediate web server by way of the network, the intermediate web server in turn being in communication with the first social networking website. The method further includes determining, based at least in part upon a user input received at the mobile device, that the mobile device should communicate directly with the first social networking website in a manner not involving the intermediate web server. The method also includes communicating with the first social networking website directly in the manner not involving the intermediate web server. In another embodiment, the method relates to interacting with a plurality of social networking sites including a first social networking website and a second social networking site.

Abstract: In a mobile device, a method of interacting with a first social networking website by way of a network includes communicating indirectly with the first social networking website by interacting with an intermediate web server by way of the network, the intermediate web server in turn being in communication with the first social networking website. The method further includes determining, based at least in part upon a user input received at the mobile device, that the mobile device should communicate directly with the first social networking website in a manner not involving the intermediate web server. The method also includes communicating with the first social networking website directly in the manner not involving the intermediate web server. In another embodiment, the method relates to interacting with a plurality of social networking sites including a first social networking website and a second social networking site.

Abstract: A photo is received from a mobile device. The photo is stored at an intermediary server. The photo is formatted at the intermediary server for at least one content provider website. The photo is transmitted to the at least one content provider website. Another method downloads a photo. The method receives in an intermediary web server, content from a content provider website. The content includes at least a photo. The intermediary server determines if the photo is new. If the photo is new, the intermediary server determines if the photo is properly formatted for the mobile device client program and sends the content including the photo to a user device including the client program.

Abstract: In a mobile device, a method of interacting with a first social networking website by way of a network includes communicating indirectly with the first social networking website by interacting with an intermediate web server by way of the network, the intermediate web server in turn being in communication with the first social networking website. The method further includes determining, based at least in part upon a user input received at the mobile device, that the mobile device should communicate directly with the first social networking website in a manner not involving the intermediate web server. The method also includes communicating with the first social networking website directly in the manner not involving the intermediate web server. In another embodiment, the method relates to interacting with a plurality of social networking sites including a first social networking website and a second social networking site.

Abstract: A photo is received from a mobile device. The photo is stored at an intermediary server. The photo is formatted at the intermediary server for at least one content provider website. The photo is transmitted to the at least one content provider website. Another method downloads a photo. The method receives in an intermediary web server, content from a content provider website. The content includes at least a photo. The intermediary server determines if the photo is new. If the photo is new, the intermediary server determines if the photo is properly formatted for the mobile device client program and sends the content including the photo to a user device including the client program.

Abstract: In one embodiment, a method of facilitating communication between a first content provider website and a mobile device includes obtaining first information from the content provider website via a first network at a web server, the first information not including any email message, where the obtaining includes pulling by way of a back end portion of the web server the first information from the content provider website. The method also includes processing in at least one of the back end portion and a front end portion of the web server the first information so as to provide processed first information, and transmitting a notice of new content in the first information from the front end portion of the web server onto a push channel established on either the first network or a second network for receipt by the mobile device.

Abstract: An aggregate service server, configured to communicate with a user device and a plurality of different content providers. A processor configured to obtain content from the plurality of different content providers and further configured to push the obtained content to the user device.

Abstract: A mobile device includes a message entry area on a display for the user to view input text, the size based on the smallest message size permitted by the one or more destination content providers. The content from the user interface input populates the message input area. A warning is generated when the limit is reached. The message with entered content is communicated to the intermediary server with the identity of the one or more content providers for uploading by the intermediary server to the one or more content providers in the format desired by the content provider website.

Abstract: A photo is received from a mobile device. The photo is stored at an intermediary server. The photo is formatted at the intermediary server for at least one content provider website. The photo is transmitted to the at least one content provider website. Another method downloads a photo. The method receives in an intermediary web server, content from a content provider website. The content includes at least a photo. The intermediary server determines if the photo is new. If the photo is new, the intermediary server determines if the photo is properly formatted for the mobile device client program and sends the content including the photo to a user device including the client program.

Abstract: In a mobile device, a method of interacting with a first social networking website by way of a network includes communicating indirectly with the first social networking website by interacting with an intermediate web server by way of the network, the intermediate web server in turn being in communication with the first social networking website. The method further includes determining, based at least in part upon a user input received at the mobile device, that the mobile device should communicate directly with the first social networking website in a manner not involving the intermediate web server. The method also includes communicating with the first social networking website directly in the manner not involving the intermediate web server. In another embodiment, the method relates to interacting with a plurality of social networking sites including a first social networking website and a second social networking site.

Abstract: In one embodiment, a method of facilitating communication between a first content provider website and a mobile device includes obtaining first information from the content provider website via a first network at a web server, the first information not including any email message, where the obtaining includes pulling by way of a back end portion of the web server the first information from the content provider website. The method also includes processing in at least one of the back end portion and a front end portion of the web server the first information so as to provide processed first information, and transmitting a notice of new content in the first information from the front end portion of the web server onto a push channel established on either the first network or a second network for receipt by the mobile device.

Abstract: According to one embodiment, a method is disclosed. The method includes launching a first application on a handheld device implementing a Palm Operating System (OS), and launching a second application. The second application is a time dependent application that runs in the background of the first application.