Abstract: Fusion proteins are provided, the fusion proteins comprising a single-chain trimer coupled to an Fc domain of an antibody. Also provided are methods of use thereof.

Abstract: The present disclosure is directed to compositions and methods of treating arthritogenic alphavirus infection. Compositions include a fusion protein comprising an Fc region, a first Mxra8 region, and a second Mxra8 region, wherein the fusion protein reduces inflammation and infection by an arthritogenic alphavirus. Methods include administering the fusion protein to a mammalian or non-mammalian subject to reduce or inhibit alphavirus infection.

Abstract: Fusion proteins are provided, the fusion proteins comprising a single-chain trimer coupled to an Fc domain of an antibody. Also provided are methods of use thereof.

Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods of treating arthritogenic alphavirus infection and methods of screening.

Abstract: A central tire inflation system for maintaining tire inflation on a vehicle is provided. The central tire inflation system includes a rotary union assembly having a housing that is coupled to and rotates with the hubcap. The housing is rotationally coupled to a stationary shaft. A flexible torque transfer shaft is connected to the stationary shaft on one end and to an axle plug on the other end. The axle plug has a hub forming a bore where the hub is movable on a web of material. The flexible torque transfer shaft and hub have cooperative non-circular shapes to resist rotation. An air vent is provided in the rotary union assembly that is isolated from the lubrication area, which inhibits the pressurized air from the central tire inflation system from pressurizing the lubrication area.

Abstract: A central tire inflation system for maintaining tire inflation on a vehicle is provided. The central tire inflation system includes a rotary union assembly having a housing that is coupled to and rotates with the hubcap. The housing is rotationally coupled to a stationary shaft. A flexible torque transfer shaft is connected to the stationary shaft on one end and to an axle plug on the other end. The axle plug has a hub forming a bore where the hub is movable on a web of material. The flexible torque transfer shaft and hub have cooperative non-circular shapes to resist rotation. An air vent is provided in the rotary union assembly that is isolated from the lubrication area, which inhibits the pressurized air from the central tire inflation system from pressurizing the lubrication area.

Abstract: A central tire inflation system for maintaining tire inflation on a vehicle is provided. The central tire inflation system includes a rotary union assembly having a housing that is coupled to and rotates with the hubcap. The housing is rotationally coupled to a stationary shaft. A flexible torque transfer shaft is connected to the stationary shaft on one end and to an axle plug on the other end. The axle plug has a hub forming, a bore where the hub is movable on a web of material. The flexible torque transfer shaft and hub have cooperative non-circular shapes to resist rotation. An air vent is provided in the rotary union assembly that is isolated from the lubrication area, which inhibits the pressurized air from the central tire inflation system from pressurizing the lubrication area.

Abstract: A mounting system is provided that mounts a fairing to the cab of a semi-tractor in a manner that hides the fasteners from view. The mounting system provides quicker assembly and disassembly among others. The mounting system may include anchor pins at one end section of the transition fairing, a single mounting screw at the opposite end section of the transition fairing, and one or more fasteners of the Snaploc® type at the mid-section of the transition fairing. Each of the couplings interface with a suitable corresponding bracket, etc, in order to mount the fairing to the associated surface of the vehicle.

Abstract: A mounting system is provided that mounts a fairing to the cab of a semi-tractor in a manner that hides the fasteners from view. The mounting system provides quicker assembly and disassembly among others. The mounting system may include anchor pins at one end section of the transition fairing, a single mounting screw at the opposite end section of the transition fairing, and one or more fasteners of the Snaploc® type at the mid-section of the transition fairing. Each of the couplings interface with a suitable corresponding bracket, etc, in order to mount the fairing to the associated surface of the vehicle.

Abstract: A shroud assembly for an engine cooling fan positioned between an engine and a radiator includes a ring shroud, a radiator shroud, and a flexible boot. The ring shroud is mounted adjacent to the fan and includes a locking feature. The radiator shroud, which is mounted to the rear of the radiator, has a first end with a first aperture for receiving air flowing rearwardly through the radiator, and a second end with a second aperture for discharging air received by the first aperture. A first end of the flexible boot engages the locking feature of the ring shroud to secure the flexible boot to the ring shroud. A second end of the flexible boot contacts the radiator shroud so that the boot provides fluid communication between the ring shroud and the radiator shroud.

Abstract: A central tire inflation system for maintaining tire inflation on a vehicle having a torque transfer sleeve connected between an axle plug assembly and a stationary shaft on the rotary union assembly. A flexible conduit extends through the axle plug to the rotary union assembly and is used to provide air pressure to tires connected to the rotary union assembly. The torque transfer sleeve limits rotational torque on the flexible conduit. Primary and secondary seals are provided on the rotary union assembly as well. A vent chamber between the primary and secondary seals allows the release of air which exits the primary seal, which prevents pressure from entering the lubrication area of the rotary union assembly.

Abstract: A method of operating a cooling fan in a cooling system for a vehicle includes determining a required speed of the cooling fan. First and second signals are provided to a motor controller operatively connected to a motor having a rotatable portion connected to the cooling fan. The first signal coarsely controls a rotational speed of the motor by adjusting a voltage level provided to the motor and the second signal finely controls the rotational speed of the motor by pulse width modulation so that the cooling fan rotates at the required speed.

Abstract: A central tire inflation system for maintaining tire inflation on a vehicle having a torque transfer sleeve connected between an axle plug assembly and a stationary shaft on the rotary union assembly. A flexible conduit extends through the axle plug to the rotary union assembly and is used to provide air pressure to tires connected to the rotary union assembly. The torque transfer sleeve limits rotational torque on the flexible conduit. Primary and secondary seals are provided on the rotary union assembly as well. A vent chamber between the primary and secondary seals allows the release of air which exits the primary seal, which prevents pressure from entering the lubrication area of the rotary union assembly.

Abstract: A cooling system for a vehicle includes a shroud attachable to a fixed portion of the vehicle. A stator assembly for a brushless DC ring motor is attached to at least one mounting support of the shroud. A cooling fan is piloted on the stator assembly, and includes a ring supporting a plurality of fan blades for sweeping an area inside the shroud. A rotor assembly for the brushless DC ring motor is attached to the ring of the cooling fan. The rotor assembly confronts the stator assembly around an outer diameter of the stator assembly. The cooling system is controlled by an electronic controller to rotate the cooling fan to provide appropriate cooling for the vehicle.

Abstract: A cooling system for a vehicle includes a shroud attachable to a fixed portion of the vehicle. A stator assembly for a brushless DC ring motor is attached to at least one mounting support of the shroud. A cooling fan is piloted on the stator assembly, and includes a ring supporting a plurality of fan blades for sweeping an area inside the shroud. A rotor assembly for the brushless DC ring motor is attached to the ring of the cooling fan. The rotor assembly confronts the stator assembly around an outer diameter of the stator assembly. The cooling system is controlled by an electronic controller to rotate the cooling fan to provide appropriate cooling for the vehicle.

Abstract: An eddy current fan drive cooling system is operable in a vehicle having a sheave rotating at a speed related to an engine speed. A driving assembly of the cooling system is attached to the sheave. A plurality of poles are exposed around an outer perimeter of the driving assembly. A plurality of windings are wrapped around the poles. The windings are electrically connected to receive a driving signal to generate a magnetic field around the poles. A driven assembly carrying a cooling fan is provided around the driving assembly. The driven assembly includes a plurality of concentric rings arranged around the exposed poles of the driving assembly. An eddy current torque is produced in the rings in response to magnetic flux passing through the rings from the exposed poles due to the magnetic field around the poles.

Abstract: The present invention provides crystals of RANKL ectodomain complexes, detailed three dimensional structural information illustrating the interaction between RANKL and RANK and methods of utilizing the X-ray crystallographic data from such crystals and other structural data disclosed to design, identify and screen for compounds that modulate activity. The present invention also relates to machine readable media embedded with the three-dimensional atomic structure coordinates of RANKL crystalline complexes and subsets thereof, together with other structural data disclosed herein.

Abstract: A cooling fan according to the present invention includes a housing. A fan assembly includes a plurality of fan blades carrying a rotor ring at the outer circumference of the fan assembly. A plurality of stator elements are supported by the housing to confront the rotor ring around only a portion of the outer circumference of the fan assembly. A motor controller is operatively connected to the stator elements to induce force on the rotor ring to turn the fan assembly.

Abstract: An eddy current fan drive cooling system is operable in a vehicle having a sheave rotating at a speed related to an engine speed. A driving assembly of the cooling system is attached to the sheave. A plurality of poles are exposed around an outer perimeter of the driving assembly. A plurality of windings are wrapped around the poles. The windings are electrically connected to receive a driving signal to generate a magnetic field around the poles. A driven assembly carrying a cooling fan is provided around the driving assembly. The driven assembly includes a plurality of concentric rings arranged around the exposed poles of the driving assembly. An eddy current torque is produced in the rings in response to magnetic flux passing through the rings from the exposed poles due to the magnetic field around the poles.

Abstract: A cooling system for a vehicle includes a shroud attachable to a fixed portion of the vehicle. A stator assembly for a brushless DC ring motor is attached to at least one mounting support of the shroud. A cooling fan is piloted on the stator assembly, and includes a ring supporting a plurality of fan blades for sweeping an area inside the shroud. A rotor assembly for the brushless DC ring motor is attached to the ring of the cooling fan. The rotor assembly confronts the stator assembly around an outer diameter of the stator assembly. The cooling system is controlled by an electronic controller to rotate the cooling fan to provide appropriate cooling for the vehicle.