Patents by Inventor Christopher A. Procyshyn
Christopher A. Procyshyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10688484Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure. The apparatus similarly allows the fluid path to be unprotected for use without the use of gloves, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontaminated is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated.Type: GrantFiled: February 18, 2018Date of Patent: June 23, 2020Assignee: VANRX PHARMASYSTEMS INC.Inventors: Christopher A. Procyshyn, Jeroen Immerzeel, Steve Sang Joon Park, Ross M. Gold
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Publication number: 20200156812Abstract: Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.Type: ApplicationFiled: June 4, 2019Publication date: May 21, 2020Inventors: Christopher A. PROCYSHYN, Juvenal NAING, John SENGER, Marcin Czeslaw CICHY
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Publication number: 20190381652Abstract: A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, a plurality of interconnected hermetically sealed arm segments, operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the plurality of arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the plurality of arm segments. The linear motion shaft may have a sealing member in the form of a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber are compatible with an aseptic and cleanable environment and the surfaces of the arm segments are shaped to avoid pooling of contaminants.Type: ApplicationFiled: December 17, 2018Publication date: December 19, 2019Inventors: Christopher A. PROCYSHYN, Jeroen IMMERZEEL, Steve Sang Joon PARK, Ross M. GOLD
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Publication number: 20190193262Abstract: A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, a plurality of interconnected hermetically sealed arm segments, operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the plurality of arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the plurality of arm segments. The linear motion shaft may have a sealing member in the form of a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber are compatible with an aseptic and cleanable environment and the surfaces of the arm segments are shaped to avoid pooling of contaminants.Type: ApplicationFiled: December 17, 2018Publication date: June 27, 2019Inventors: Christopher A. PROCYSHYN, Jeroen IMMERZEEL, Steve Sang Joon PARK, Ross M. GOLD
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Publication number: 20190054459Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure. The apparatus similarly allows the fluid path to be unprotected for use without the use of gloves, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontaminated is completed.Type: ApplicationFiled: February 18, 2018Publication date: February 21, 2019Inventors: Christopher A. PROCYSHYN, Jeroen IMMERZEEL, Steve Sang Joon PARK
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Patent number: 10081527Abstract: An apparatus and method are presented for removing container covers within a controlled environment enclosure without using gloves. The apparatus comprises an articulated arm apparatus and a gripping apparatus and can further comprise a controller. The articulated arm apparatus can be configurable for holding and moving a container in three dimensions; and the gripping apparatus can be configured for gripping a container cover sealing the container. The method comprises moving the container using the articulated arm apparatus while holding a gripping area of the container cover substantially stationary using the gripping apparatus. The apparatus can further comprise a sensor configured for supplying information to the controller for determining the location of the container cover gripping area and an orientation of the container cover. The method can further comprise inspecting the container cover using the sensor. The container can be moved along a path and within a space determined by the controller.Type: GrantFiled: May 3, 2013Date of Patent: September 25, 2018Assignee: VANRX PHARMASYSTEMS INC.Inventors: Ross M. Gold, Steve Sang Joon, Christopher A. Procyshyn, Jeroen Immerzeel, Paul Nowaczyk
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Publication number: 20160346777Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure. The apparatus similarly allows the fluid path to be unprotected for use without the use of gloves, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated.Type: ApplicationFiled: July 20, 2012Publication date: December 1, 2016Inventors: Jeroen IMMERZEEL, Christopher A. PROCYSHYN, Steve Sang Joon Park
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Publication number: 20160251206Abstract: An apparatus and method are presented for removing container covers within a controlled environment enclosure without using gloves. The apparatus comprises an articulated arm apparatus and a gripping apparatus and can further comprise a controller. The articulated arm apparatus can be configurable for holding and moving a container in three dimensions; and the gripping apparatus can be configured for gripping a container cover sealing the container. The method comprises moving the container using the articulated arm apparatus while holding a gripping area of the container cover substantially stationary using the gripping apparatus. The apparatus can further comprise a sensor configured for supplying information to the controller for determining the location of the container cover gripping area and an orientation of the container cover. The method can further comprise inspecting the container cover using the sensor. The container can be moved along a path and within a space determined by the controller.Type: ApplicationFiled: May 3, 2013Publication date: September 1, 2016Applicant: VANRX PHARMACEUTICALS, INS.Inventors: Ross M. GOLD, Steve Sang Joon PARK, Christopher A. PROCYSHYN, Jeroen IMMERZEEL, Paul NOWAKCZYK
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Publication number: 20150196494Abstract: The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox-active, metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the picoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.Type: ApplicationFiled: March 25, 2015Publication date: July 16, 2015Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Ernest S.Y. Wong, Christen M. Giandomenico
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Publication number: 20130202690Abstract: The invention provides an encapsulated unit dosage form for picoplatin that is adapted for oral administration of the picoplatin containing a substantially dry powder with about 20 to 55 wt % picoplatin in the physical form of a picoplatin particulate wherein an average picoplatin particle diameter is less than about 10 microns. The picoplatin particles are dispersed within the powder of the formulation which includes a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate and an effective amount of up to about 5 wt % of a lubricant.Type: ApplicationFiled: September 27, 2012Publication date: August 8, 2013Applicant: Poniard Pharmaceuticals, Inc.Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Angelica F. Phillips, Hazel B. Breitz
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Publication number: 20130183433Abstract: The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox- active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the pieoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.Type: ApplicationFiled: August 16, 2012Publication date: July 18, 2013Applicant: Poniard Pharmaceuticals, Inc.Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Ernest S.Y. Wong, Christen M. Giandomenico
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Publication number: 20110033528Abstract: The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox-active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the picoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.Type: ApplicationFiled: August 5, 2009Publication date: February 10, 2011Applicant: Poniard Pharmaceuticals, Inc.Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Ernest S.Y. Wong, Christen M. Giandomenico
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Publication number: 20100310661Abstract: The invention provides formulations for the organoplatinum anticancer drug picoplatin. Self emulsifying compositions, stabilized nanoparticulate compositions, solid dispersions, and nanoparticulate suspensions in oils are provided, along with methods for preparation of the formulations. The formulations can provide improved oral availability of picoplatin relative a to a simple solution of picoplatin such as in water or normal saline solution and can be used in combination therapy.Type: ApplicationFiled: July 16, 2008Publication date: December 9, 2010Applicant: Poniard Pharmaceuticals, Inc.Inventors: Andrew Xian Chen, Cheni Kwok, Christopher A. Procyshyn
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Publication number: 20100215727Abstract: Methods for stabilizing aqueous solutions of picoplatin are provided. Such stable, preferably aseptic solutions are particularly useful for preparing unit dosages of picoplatin for oral or intravenous administration, preferably in combination with at least one additional non-platinum anti-cancer agent.Type: ApplicationFiled: December 10, 2009Publication date: August 26, 2010Applicant: Poniard Pharmaceuticals, Inc.Inventors: Alistair J. Leigh, Ronald A. Martell, David A. Karlin, Cheni Kwok, Christopher A. Procyshyn, Hazel B. Breitz, Paul L. Weiden
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Publication number: 20100062056Abstract: The invention provides an encapsulated unit dosage form for picoplatin that is adapted for oral administration of the picoplatin containing a substantially dry powder with about 20 to 55 wt % picoplatin in the physical form of a picoplatin particulate wherein an average picoplatin particle diameter is less than about 10 microns. The picoplatin particles are dispersed within the powder of the formulation which includes a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate and an effective amount of up to about 5 wt % of a lubricant.Type: ApplicationFiled: August 5, 2009Publication date: March 11, 2010Applicant: Poniard Pharmaceuticals, Inc.Inventors: Alistair J. Leigh, Christopher A. Procyshyn, Angelica Phillips, Hazel B. Breitz
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Publication number: 20090223592Abstract: Systems and methods permit filling containers with a product. A filling arm is disposed within a chamber. An optical sensor is configured to sense openings of the containers within the chamber. Locations of the sensed openings are used to guide the filling arm to fill the containers with a product.Type: ApplicationFiled: February 26, 2009Publication date: September 10, 2009Applicant: VanRx Pharmaceuticals, Inc.Inventors: Christopher A. Procyshyn, Ross M. Gold