Abstract: This disclosure concerns fatty acid derivatives, pharmaceutical compositions comprising the fatty acid derivatives, and methods of using the fatty acid derivatives, for example, to treat inflammation, chronic itch, chronic pain, an autoimmune disorder, atherosclerosis, a skin disorder, arthritis, a neurodegenerative disorder, or a psychiatric disorder in a subject. In some embodiments, the fatty acid derivative is a compound, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, having a structure according to: wherein X is from 1-16 carbons in length, Z is aliphatic from 1-16 carbons in length, or is not present, Y is selected from: R1, R2, and R3 are independently hydrogen or lower alkyl, R4 is lower alkyl, hydroxyl, carboxyl, or amine, R5 is hydrogen, lower alkyl, or halide, R6 is hydroxyl or substituted thiol, and each R7 is independently hydrogen or fluoride or is not present and the adjacent carbons form alkyne.

Abstract: This disclosure concerns fatty acid derivatives, pharmaceutical compositions comprising the fatty acid derivatives, and methods of using the fatty acid derivatives, for example, to treat inflammation, chronic itch, chronic pain, an autoimmune disorder, atherosclerosis, a skin disorder, arthritis, a neurodegenerative disorder, or a psychiatric disorder in a subject. In some embodiments, the fatty acid derivative is a compound, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, having a structure according to: wherein X is from 1-16 carbons in length, Z is aliphatic from 1-16 carbons in length, or is not present, Y is selected from: R1, R2, and R3 are independently hydrogen or lower alkyl, R4 is lower alkyl, hydroxyl, carboxyl, or amine, R5 is hydrogen, lower alkyl, or halide, R6 is hydroxyl or substituted thiol, and each R7 is independently hydrogen or fluoride or is not present and the adjacent carbons form alkyne.

Abstract: This disclosure concerns fatty acid derivatives, pharmaceutical compositions comprising the fatty acid derivatives, and methods of using the fatty acid derivatives, for example, to treat inflammation, chronic itch, chronic pain, an autoimmune disorder, atherosclerosis, a skin disorder, arthritis, a neurodegenerative disorder, or a psychiatric disorder in a subject. In some embodiments, the fatty acid derivative is a compound, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, having a structure according to: wherein X is from 1-16 carbons in length, Z is aliphatic from 1-16 carbons in length, or is not present, Y is selected from: R1, R2, and R3 are independently hydrogen or lower alkyl, R4 is lower alkyl, hydroxyl, carboxyl, or amine, R5 is hydrogen, lower alkyl, or halide, R6 is hydroxyl or substituted thiol, and each R7 is independently hydrogen or fluoride or is not present and the adjacent carbons form alkyne.

Abstract: The present technology relates to apparatus and methods having a plurality for chambers for storing edible substances. More particularly, the present technology relates to container caps, storage units, kits, and methods for sealing and isolating a plurality of edible substances. Certain embodiments present storage units comprising a plurality of sealed and isolated substances that connect to the cap of a beverage container using a snap-fit or a friction fit connection.

Abstract: There is disclosed a method of carrying frame based data, eg Ethernet data, over a synchronous digital hierarchy network in order to provide local area network type functionality over a wide area network coverage. Specific embodiments disclose methods of mapping Ethernet data frames into SDH virtual containers, and distinguishing start and end boundaries of the Ethernet data frames within the virtual container payloads, by a selection of encoding methods including a segmentation, pointer methods, bit stuffing methods and byte stuffing methods. Data frames are encoded with a code which designates a boundary of each frame, and the encoded frames are input into a synchronous data channel.

Abstract: A method of transmitting OSI layer 2 datacoms data by direct incorporation into a plurality of synchronous digital hierarchy virtual containers is disclosed, in which a higher bit rate OSI layer 2 data frame is multiplexed into a plurality of lower bit rate SDH (or SONET) virtual containers, which are transmitted simultaneously and in parallel over a synchronous communications network. The plurality of virtual containers are virtually concatenated by association of the payloads of the plurality of virtual containers. Re-assembly of the OSI layer 2 data frames from a plurality of virtually concatenated VCs is achieved by storing each received VC payload corresponding to an OSI layer 2 data frame in a corresponding respective memory location, and alternately reading interleaved bytes from the plurality of payloads under control of a plurality of read pointers.

Abstract: A frame based data communications network is interfaced to a synchronous digital hierarchy network via a plurality of frame based data port cards incorporated into a plurality of synchronous multiplexers. Each port card comprises a conventional frame based data port, a frame switch, a rate adapter means and a mapping means for mapping data frames into a plurality of SDH virtual containers. Frame based data is incorporated directly into a synchronous virtual container without encapsulation in an intermediate protocol. A number of topologies of a frame based data channel network are possible, overlaid on the underlying synchronous transport network, including an open loop topology, a ring mode topology, and a backhaul topology.

Abstract: There is disclosed a method of carrying frame based data, eg Ethernet data, over a synchronous digital hierarchy network in order to provide local area network type functionality over a wide area network coverage. Specific embodiments disclose methods of mapping Ethernet data frames into SDH virtual containers, and distinguishing start and end boundaries of the Ethernet data frames within the virtual container payloads, by a selection of encoding methods including a segmentation, pointer methods, bit stufifng methods and byte stuffing methods. Data frames are encoded with a code which designates a boundary of each frame, and the encoded frames are input into asynchronous data channel.

Abstract: There is disclosed a method of carrying frame based data, eg Ethernet data, over a synchronous digital hierarchy network in order to provide local area network type functionality over a wide area network coverage. Specific embodiments disclose methods of mapping Ethernet data frames into SDH virtual containers, and distinguishing start and end boundaries of the Ethernet data frames within the virtual container payloads, by a selection of encoding methods including a segmentation, pointer methods, bit stuffing methods and byte stuffing methods. Data frames are encoded with a code which designates a boundary of each frame, and the encoded frames are input into a synchronous data channel.

Abstract: There is disclosed a method of carrying frame based data, eg Ethernet data, over a synchronous digital hierarchy network in order to provide local area network type functionality over a wide area network coverage. Specific embodiments disclose methods of mapping Ethernet data frames into SDH virtual containers, and distinguishing start and end boundaries of the Ethernet data frames within the virtual container payloads, by a selection of encoding methods including a segmentation, pointer methods, bit stuffing methods and byte stuffing methods. Data frames are encoded with a code which designates a boundary of each frame, and the encoded frames are input into a synchronous data channel.

Abstract: There is disclosed a method of carrying frame based data, eg Ethernet data, over a synchronous digital hierarchy network in order to provide local area network type functionality over a wide area network coverage. Specific embodiments disclose methods of mapping Ethernet data frames into SDH virtual containers, and distinguishing start and end boundaries of the Ethernet data frames within the virtual container payloads, by a selection of encoding methods including a segmentation, pointer methods, bit stuffing methods and byte stuffing methods. Data frames are encoded with a code which designates a boundary of each frame, and the encoded frames are input into a synchronous data channel.

Abstract: 3-(N,N-Dimethylcarbamoyl)pyrazolo[1,5-a]pyridine of the formula: ##STR1## which is a new compound, possesses pharmacological properties, in particular properties which are indicative of outstanding utility in the treatment of arthritic disorders such as rheumatoid arthritis. The compound can be prepared by reacting a pyrazolo[1,5-a]pyridine-3-carbonyl halide (e.g. chloride) with dimethylamine.

Abstract: New tetrazole derivatives of the general formula: ##STR1## [wherein R.sup.1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula:--CR.sup.2 .dbd.NOR.sup.3 II(wherein R.sup.