Abstract: Provided are computing systems, methods, and platforms that automatically produce production-ready machine learning models and deployment pipelines from minimal input information such as a raw training dataset. In particular, one example computing system can import a training dataset associated with a user. The computing system can execute an origination machine learning pipeline to perform a model architecture search that selects and trains a machine learning model for the training dataset. Execution of the origination machine learning pipeline can also result in generation of a deployment machine learning pipeline configured to enable deployment of the machine learning model (e.g., running the machine learning model to produce inferences and/or optionally other tasks such as re-training and/or re-tuning the model).

Abstract: Disclosed herein is processed dermis graft for use in orthopedic surgical procedures. Specifically exemplified herein is a processed dermis graft comprising one or more bone blocks having a groove cut into the surface thereof, wherein said groove is sufficient to accommodate a fixation screw. Also disclosed is a method of processing dermis that results in a dermis derived implant suitable to replace a tendon or ligament in a recipient in need thereof. Other compositions and applications of a dermis derived implant, and methods of manufacture and use, are disclosed.

Abstract: Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.

Abstract: Disclosed herein are methods and implants for enhancing or restoring the mechanical function of collagenous tissue. Specifically exemplified is the replacement or repair of endogenous nucleus pulposus with allogenic, xenogenic, or both nucleus pulposus that has been augmented with growth factors and glycosaminoglycans, via injection into a weakened intervertebral disc. Also disclosed is an implant to restore mechanical function to a damaged vertebral column. Additionally, methods and products for augmenting the extracellular matrix and cell content of a damaged nucleus pulposus through infusion of selected stem cells and other restorative materials are disclosed. The methods and products disclosed may be adapted for use in repair of all soft or hard tissue found in association with articulating joints.