Abstract: A microchannel cooling block includes: a base plate; a microchannel array including a plurality of thermally conductive plates connected to and extending from a surface of the base plate, the thermally conductive plates being aligned so that a highest or second highest thermally conductive axis thereof extends away from the surface of the base plate, adjacent ones of the thermally conductive plates being spaced apart from each other to form a plurality of microchannels between the thermally conductive plates, one of the microchannels being between each adjacent two of the thermally conductive plates; and a manifold connected to the thermally conductive plates, an interior of the manifold being in fluid communication with the microchannels in the microchannel array.

Abstract: The present disclosure provides a computing device (100) for classification of an aspirating/dispensing operation in an automated analyzer (50). The computing device (100) comprises a memory (22) storing a neural network model (24). The neural network model 24 sequentially comprises a plurality of convolution blocks (202-1, 202-2 . . . 202-N). The computing device (100) further comprises a processor (20) communicably coupled to the memory (22) and at least one measurement sensor (106) associated with a pipetting probe (104) of a pipetting device (102). The processor (20) is capable of executing the neural network model (24). The processor (20) is further capable of executing instructions (26) to classify the aspirating/dispensing operation into at least one correct class or at least one incorrect class.

Abstract: A compound having the following structure of Formula (IV): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: The present invention relates to apparatuses for cutting and removing occlusive material with imaging capabilities. According to certain aspects, the apparatus includes a catheter body, a rotatable shaft, and an imaging element. The catheter body defines a lumen and includes a distal housing that defines an opening. The rotatable shaft is disposed within the lumen of the catheter body. The rotatable shaft includes a conveying component and a cutting element that is at least partially surrounded by the distal housing. The imaging element is located on the distal housing of the catheter body.

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

Abstract: Embodiments of a wireless access node for dynamically transmitting an identification signal and/or detecting identification signals from other transmit nodes when operating in unlicensed spectrum and embodiments of a method of operation thereof are disclosed. In some embodiments, a method in a wireless access node that operates in an unlicensed frequency spectrum comprises determining, based on one or more parameters, whether the wireless access node is to transmit an identification signal and/or detect identification signals from other transmit nodes. The method further comprises operating in accordance with a result of the determining whether to transmit the identification signal and/or to detect identification signals from other transmit nodes. In this manner, throughput can be improved.

Abstract: In an example, a threat intelligence controller is configured to operate on a data exchange layer (DXL). The threat intelligence controller acts as a DXL consumer of reputation data for a network object, which may be reported in various different types and from various different sources. Of the devices authorized to act as reputation data producers, each may have its own trust level. As the threat intelligence controller aggregates data from various providers, it may weight the reputation reports according to trust level. The threat intelligence engine thus builds a composite reputation for the object. When it receives a DXL message requesting a reputation for the object, it publishes the composite reputation on the DXL bus.

Abstract: One or more datalink labels are displayed on a shared panel of a user interface. The datalink labels are generated in response to receiving a datalink message from at least one ground station. Upon receiving a selection of the datalink label, one or more sub-panels that include information or a representation of the datalink message are displayed on the user interface. In some embodiments, the sub-panel includes a button that, when selected, automatically generates a response message. Utilizing datalink labels in conjunction with the shared panel simplifies datalink messaging and enables messaging functions to be completed on the same screen regardless of which application (or function of an application) is currently displayed on the user interface.

Abstract: Optimizing copy operations in a storage array, includes combining, in dependence upon a metadata optimization policy, a plurality of copy operations into a single copy operation and splitting the single copy operation into an optimized set of executable copy operations that copy data based on memory alignment.

Abstract: Medical devices and methods of using medical devices are disclosed. An example tissue engagement device includes a first actuation member including a body coupled to a first jaw and a second jaw at a pivot point, wherein the body is designed to shift between a first configuration and a first compressed configuration and a second actuation member coupled to the first actuation member at the pivot point and at a fixation point, wherein the second actuation member is designed to shift between a second configuration and a second compressed configuration. Further, shifting the first actuation member from the first configuration to the first compressed configuration, shifting the second actuation member from the second configuration to the second compressed configuration, or both, shifts the first jaw and the second jaw between a closed configuration and an open configuration.

Abstract: The present disclosure provides compounds of formula (I?) and uses thereof for the treatment of cancer. Also provided are pharmaceutical compositions and kits comprising the same compounds. The present compounds may have improved anti-tumor effect and reduced toxicity and may be useful for targeting mitochondria in cancer cells.

Abstract: A medical system may include a fluid source, a fluid reservoir, and a valve. The valve may be coupled to the fluid source and the fluid reservoir so as to permit fluid flow between the fluid source and the fluid reservoir. The valve may include a first opening configured to receive a medical instrument. Upon insertion of the medical instrument into the first opening of the valve, the medical instrument may be lubricated with a fluid from the fluid source.

Abstract: An insert for a rectilinear container having side walls, a bottom wall, and upper end panels defining an inner chamber includes a corrugated cardboard insert configured to secure at least one item within the inner chamber and provide cushioning thereto. There is a first panel having a bottom panel portion, a first side panel portion, and a second side panel portion. The bottom, first side and second side panel portions including a plurality of laterally corresponding parallel spaced ridges and channels. Interfaces between the bottom and side panels being pivotable such that the side panels can pivot at an angle relative to the bottom panel. When the insert is inserted into a rectilinear container, the bottom panel portion contacts a bottom wall of the container, the side panel portions pivot to a generally perpendicular angle relative the bottom panel portion to contact the side wall portion of the container to secure and cushion an item placed therein.

Abstract: A contact record enrichment system receives contact records generated by a contact center platform in association with individual contacts handled by a contact center. If multiple contacts are part of a contact chain associated with the same customer journey, such as a customer journey that involves one or more transfers between different contacts, the contact record enrichment system enriches corresponding contact records with transfer data about the entire customer journey. The transfer data added to an individual contact record for an individual contact in the customer journey causes the contact record to indicate information about the entire customer journey, in addition to information about the individual contact.

Abstract: A method for preparing digital image data from an analog image input by scanning, and reducing visibility of the scanning noise, may include estimating a visibility of scanning noise, and a number of scanning samples needed to reduce scanning noise to below a visible threshold. Related methods include scanning, by an analog-to-digital image scanner, an analog image for multiple iterations, resulting in digital image data for each of the iterations; calculating a noise statistic for individual pixels of digital image data across the iterations; determining true values of individual pixels of the digital image data based on the noise statistic for each of the individual pixels and generating scanner noise reduced digital image data wherein pixels are assigned their respective ones of the true values; and saving the scanner noise reduced digital image data in a computer memory.

Abstract: An entertainment system provides data to a common screen (e.g., cinema screen) and personal immersive reality devices. For example, a cinematic data distribution server communicates with multiple immersive output devices each configured for providing immersive output (e.g., a virtual reality output) based on a data signal. Each of the multiple immersive output devices is present within eyesight of a common display screen. The server configures the data signal based on digital cinematic master data that includes immersive reality data. The server transmits the data signal to the multiple immersive output devices contemporaneously with each other, and optionally contemporaneously with providing a coordinated audio-video signal for output via the common display screen and shared audio system.

Abstract: Embodiments of negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a pump assembly, canister, and a wound dressing configured to be positioned over a wound. The pump assembly, canister, and the wound dressing can be fluidically connected to facilitate delivery of negative pressure to a wound. The pump assembly can present graphical user interface screens for controlling and monitoring delivery of negative pressure. The system can be configured to efficiently deliver negative pressure and to detect and indicate presence of certain conditions, such as low pressure, high pressure, leak, canister full, and the like. Monitoring and detection of operating condition can be performed by measuring one or more operational parameters, such as pressure, flow rate, and the like.