Abstract: Systems, devices, and methods including a processor having addressable memory, where the processor is configured to: collect, via a set of sensors, biological signals related to patient status; collect, via an environmental monitoring device, environmental data associated with an environment of the patient; store, locally via a secure encrypted local database, the collected biological signals and the collected environmental data; detect an abnormality in the collected biological signals; increase measurement frequency of the biological signals by the set of sensors based on the detected abnormality; detect an error in the collected biological signals; determine whether the detected error in the collected biological signals of the current reading is due to environmental factors; correct the determined error in the collected biological signals; and transmit the error corrected collected biological signals as encrypted data.

Abstract: A storage, retrieval and processing system for processing objects is disclosed.

Abstract: The present disclosure provides, inter alia, antibody drug conjugates that are useful in treating various diseases such as cancer. The antibody drug conjugates can be configured to elicit tumor site-specific responses, including tumor microenvironment immunostimulation, while limiting off-target and systemic effects. In certain embodiments disclosed herein, the antibody drug conjugates are configured to release payloads following internalization by immune, cancer, or tumor associated cells.

Abstract: A continuous glucose monitor for wirelessly transmitting data relating to glucose value to a plurality of displays is disclosed, as well as systems and methods for limiting the number of display devices that can connect to a continuous glucose transmitter. In addition, security, including hashing techniques and a changing application key, can be used to provide secure communications between the continuous glucose transmitter and the displays. Also provided is a continuous glucose monitor and techniques for authenticating multiple displays, providing secure data transmissions to multiple displays, and coordinating the interaction of commands and data updates between multiple displays.

Abstract: The present invention is directed to compositions and methods of treating or preventing diseases or disorders with inhibitors of SHP2, alone, and in combination with other therapeutic agents such as RAS pathway inhibitors (e.g., MEK inhibitors); methods of establishing appropriate treatment plans for subjects based upon the expression of one or more biomarker indicative of SHP2 inhibitor sensitivity; and methods of determining sensitivity to a SHP2 inhibitor based on a phosphorylation status of SHP2.

Abstract: A method of processing objects using a programmable motion device is disclosed. The method includes the steps of providing an input conveyance system by which input bins of objects may be provided to a processing station that includes the programmable motion device that includes an end effector, perceiving at the processing station identifying indicia representative of an identity of a plurality of objects at an input area of the input conveyance system, grasping the an acquired object using the end effector, moving the acquired object toward an identified processing container using the programmable motion device, the identified processing container being associated with the identifying indicia and said identified processing container being provided as one of a plurality of processing containers at the processing station, and providing an output conveyance system in communication with the processing station, by which processing containers that contain processed objects may be provided.

Abstract: Systems and methods are described for determining a peripheral's location based on observations from a plurality of centrals. A central may periodically transmit its location and observations of peripherals to a backend. The backend may match the location of the central with one or more observations of a peripheral to estimate a location of the peripheral. The backend may receive observations of the same peripheral from a plurality of centrals. The backend may aggregate estimated locations to triangulate a more precise location of the peripheral.

Abstract: An object processing system is disclosed that includes a plurality of track sections, and a plurality of remotely actuatable carriers for controlled movement along at least portions of the plurality of track sections, each of the actuatable carriers being instructed at any time to move a limited number of track section only.

Abstract: A computer system includes a physical memory having a first page table and a second page table, and an address translation module. The first page table includes primary page table entries, where each page table entry among the primary page table entries is configured to store a mapping of a virtual memory address to a physical memory address and auxiliary information. The second page table includes secondary page table entries each storing at least one further auxiliary information, where each secondary page table entry corresponds to a primary page table entry in the first page table. The address translation module is configured to, in response to receiving a request from a processor, walk through the first page table to identify a primary page table entry and consecutively identify a location of a corresponding secondary page table entry based on a location of the primary page table entry.

Abstract: Methods for encasing bodies including smokeless tobacco or a tobacco substitute with a polymeric casing can include coating a compressed body with microfibers, applying tubular casings to compressed bodies, printing netting and webs on compressed bodies, injection molding around compressed bodies, applying a webbing to compressed bodies, placing compressed bodies into a skin forming bath, and including thermoplastic polymers in a compressed body.

Abstract: A microchannel cooling block includes: a base plate; a microchannel array including a plurality of thermally conductive plates connected to and extending from a surface of the base plate, the thermally conductive plates being aligned so that a highest or second highest thermally conductive axis thereof extends away from the surface of the base plate, adjacent ones of the thermally conductive plates being spaced apart from each other to form a plurality of microchannels between the thermally conductive plates, one of the microchannels being between each adjacent two of the thermally conductive plates; and a manifold connected to the thermally conductive plates, an interior of the manifold being in fluid communication with the microchannels in the microchannel array.

Abstract: A compound having the following structure of Formula (IV): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: The present disclosure provides a computing device (100) for classification of an aspirating/dispensing operation in an automated analyzer (50). The computing device (100) comprises a memory (22) storing a neural network model (24). The neural network model 24 sequentially comprises a plurality of convolution blocks (202-1, 202-2 . . . 202-N). The computing device (100) further comprises a processor (20) communicably coupled to the memory (22) and at least one measurement sensor (106) associated with a pipetting probe (104) of a pipetting device (102). The processor (20) is capable of executing the neural network model (24). The processor (20) is further capable of executing instructions (26) to classify the aspirating/dispensing operation into at least one correct class or at least one incorrect class.

Abstract: In an example, a threat intelligence controller is configured to operate on a data exchange layer (DXL). The threat intelligence controller acts as a DXL consumer of reputation data for a network object, which may be reported in various different types and from various different sources. Of the devices authorized to act as reputation data producers, each may have its own trust level. As the threat intelligence controller aggregates data from various providers, it may weight the reputation reports according to trust level. The threat intelligence engine thus builds a composite reputation for the object. When it receives a DXL message requesting a reputation for the object, it publishes the composite reputation on the DXL bus.

Abstract: The present invention relates to apparatuses for cutting and removing occlusive material with imaging capabilities. According to certain aspects, the apparatus includes a catheter body, a rotatable shaft, and an imaging element. The catheter body defines a lumen and includes a distal housing that defines an opening. The rotatable shaft is disposed within the lumen of the catheter body. The rotatable shaft includes a conveying component and a cutting element that is at least partially surrounded by the distal housing. The imaging element is located on the distal housing of the catheter body.