Abstract: Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.

Abstract: The present disclosure relates to 6,6-fused heterocyclic compounds and related compounds and their use in treating a disease or condition responsive to modulation or inhibition of METTL3.

Abstract: A masterbatch for use in the production of thermoplastic vulcanizates comprises stannous chloride powder and zinc oxide powder encapsulated together in a polymer, such as an ethylene propylene diene terpolymer.

Abstract: A masterbatch for use in the production of thermoplastic vulcanizates comprises stannous chloride powder and zinc oxide powder encapsulated together in a polymer, such as an ethylene propylene diene terpolymer.

Abstract: An apparatus for applying product to the skin of a person in a booth, comprising: an applicator configured to apply the product to the person; a first guide configured to guide movement of an applicator in a first dimension, in order to enable the applicator to apply the product to the person at a plurality of different heights; and a second guide configured to guide movement of the applicator in a second dimension, in order to enable the applicator to apply the product across the width of the person. The apparatus may comprise control circuitry for controlling the applicator in dependence upon the weight of the person.

Abstract: An apparatus (100) for applying product to the skin of a person in a booth (10), comprising: an applicator (57) configured to apply the product to the person; a first guide (40) configured to guide movement of an applicator in a first dimension, in order to enable the applicator to apply the product to the person at a plurality of different heights; and a second guide (20) configured to guide movement of the applicator in a second dimension, in order to enable the applicator to apply the product across the width of the person. The apparatus may comprise control circuitry for controlling the applicator in dependence upon the weight of the person.

Abstract: A multilayered optical tissue phantom fabrication approach and inherently produced test target structure which address the issues of of optical conformity known in the art by controlling the formation of micrometer scale monolayers embedded with light-scattering microspheres.

Abstract: A multilayered optical tissue phantom fabrication approach and inherently produced test target structure which address the issues of optical conformity known in the art by controlling the formation of micrometer scale monolayers embedded with light-scattering microspheres.

Abstract: An apparatus (100) for applying product to the skin of a person in a booth (10), comprising: an applicator (57) configured to apply the product to the person; a first guide (40) configured to guide movement of an applicator in a first dimension, in order to enable the applicator to apply the product to the person at a plurality of different heights; and a second guide (20) configured to guide movement of the applicator in a second dimension, in order to enable the applicator to apply the product across the width of the person. The apparatus may comprise control circuitry for controlling the applicator in dependence upon the weight of the person.

Abstract: A method of improving hot water supply performance of a water heater is provided. The method includes coupling an outlet port of a water tempering device to the cold water inlet port of a water heater for delivering cold water from the cold water supply line into the water storage tank. The inlet port of the tempering device is coupled to the hot water outlet port of the water heater for receiving hot water from the water storage tank to the hot water supply line. A conduit of the tempering device is positioned between the inlet and outlet ports of the tempering device for diverting a portion of the cold water delivered from the cold water supply line into the conduit. The tempering device mixes the diverted cold water with the hot water received from the water storage tank, and delivers the mixed water into the hot water supply line.

Abstract: A water heater assembly includes a water storage tank configured for containing water; an inlet port positioned on the water storage tank for receiving cold water delivered from a cold water supply line; an outlet port positioned on the water storage tank for distributing hot water from the water storage tank toward a hot water supply line; and a water tempering device releasably coupled to both the inlet port and to the outlet port for diverting a portion of the cold water from the cold water supply line to the hot water supply line, wherein the water tempering device is configured to selectively mix the cold water with the hot water for delivery of mixed water into the hot water supply line.

Abstract: A flue system is provided for a water heater having improved heat exchange efficiency. The flue system includes an upstream heat exchange portion having at least one substantially vertical flue tube. The flue system also includes a downstream heat exchange portion having at least one substantially vertical flue tube. The upstream heat exchange portion provides a first pass for heat exchange with water in a water heater. The downstream heat exchange portion provides a second pass for heat exchange with water in the water heater.

Abstract: A kit, device and method for improving the hot water supply performance of a water heater are provided. The device comprises a fitting, a conduit, and a mixing device. The fitting includes an inlet port configured for coupling with a cold water supply line, an outlet port configured for releasably coupling with a cold water inlet port of the water heater, and a bypass port configured for diverting a portion of the cold water from the cold water supply line. The conduit includes an inlet port configured for coupling with the bypass port of the fitting and an outlet port. The mixing device includes a mixing port for coupling with the outlet port of the conduit, an inlet port for releasably coupling with a hot water outlet port of a water heater, and an outlet port for coupling with a hot water supply line.

Abstract: A booth (2) for accommodating a person, the booth (2) defining a booth volume (4) and comprising: a base portion (6) and a top portion (8); flow means for causing air to move in a downward air flow within the booth (2), the downward airflow defining a predetermined volume within the booth (2); recirculating means (18) for recirculating the air within the booth (2); iltering means (20) for filtering the air within the booth (2); and projecting means for projecting a product into at least some of the booth volume and onto a body of a person positioned in the booth (2).

Abstract: A booth (2) for accommodating a person, the booth (2) defining a booth volume (4) and comprising: a base portion (6) and a top portion (8); flow means (18) for causing a downward airflow within the booth (2); projecting means (22) for projecting product into at least some of the booth volume (4) within the booth (2) and, in use, onto a body of a person positioned in the booth (2); and control means (90) for controlling the projection of the product.

Abstract: A flue system is provided for a water heater having improved heat exchange efficiency. The flue system includes an upstream heat exchange portion having at least one substantially vertical flue tube. The flue system also includes a downstream heat exchange portion having at least one substantially vertical flue tube. The upstream heat exchange portion provides a first pass for heat exchange with water in a water heater. The downstream heat exchange portion provides a second pass for heat exchange with water in the water heater.