Abstract: Provided herein are methods and compositions related to the treatment or prevention of cancer (e.g., by targeting a tumor in a subject with cancer) by administering to a subject an agent that inhibits autophagy. In certain aspects, provided herein are methods of compositions related to methods of sensitizing cancer cells to tumor necrosis factor-alpha (TNF-?) mediated killing by contacting the cells or administering the agent that inhibits autophagy.

Abstract: Provided herein are bispecific antigen-binding molecules that bind HER2 and methods of use thereof. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different (preferably non-overlapping) epitopes of the extracellular domain of human HER2. The bispecific antigen-binding molecules cluster on the surface of HER2 IHC2+ and IHC3+ cells, and are internalized into the cellular lysosomes. Also included are antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety, as well as methods of treating cancer in a subject by administering to the subject a bispecific antigen-binding molecule or an ADC thereof.

Abstract: Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.

Abstract: A data processing system for discovering a semantic meaning of a field included in one or more data sets is configured to identify a field included in one or more data sets, with the field having an identifier. For that field, the system profiles data values of the field to generate a data profile, accesses a plurality of label proposal tests, and generates a set of label proposals by applying the plurality of label proposal tests to the data profile. The system determines a similarity among the label proposals and selects a classification. The system identifies one of the label proposals as identifying the semantic meaning. The system stores the identifier of the field with the identified one of the label proposals that identifies the semantic meaning.

Abstract: A data processing system for discovering a semantic meaning of a field included in one or more data sets is configured to identify a field included in one or more data sets, with the field having an identifier. For that field, the system profiles data values of the field to generate a data profile, accesses a plurality of label proposal tests, and generates a set of label proposals by applying the plurality of label proposal tests to the data profile. The system determines a similarity among the label proposals and selects a classification. The system identifies one of the label proposals as identifying the semantic meaning. The system stores the identifier of the field with the identified one of the label proposals that identifies the semantic meaning.

Abstract: A data processing system for discovering a semantic meaning of a field included in one or more data sets is configured to identify a field included in one or more data sets, with the field having an identifier. For that field, the system profiles data values of the field to generate a data profile, accesses a plurality of label proposal tests, and generates a set of label proposals by applying the plurality of label proposal tests to the data profile. The system determines a similarity among the label proposals and selects a classification. The system identifies one of the label proposals as identifying the semantic meaning. The system stores the identifier of the field with the identified one of the label proposals that identifies the semantic meaning.

Abstract: A process is provided for laser welding a nickel or cobalt based superalloy article to minimize cracking by preheating the entire weld area to a ductile temperature, maintaining such temperature during welding and solidification of the weld, with the welding utilizing a powder alloy feed and the speed of the laser controlled to less than 10 inches per minute.

Abstract: A protective gas shroud for welding is provided by: positioning an article into a chamber having an opening at the top to permit welding of the article; introducing argon into the body of the chamber to act as a protective gas shroud for the article during welding; introducing helium into the open top of the chamber to assist in maintaining a protective gas shroud around the article during welding; and welding the article within the protective gas shroud.