Abstract: User sessions are authenticated based on locations associated with a user account used for sending a request for creating a session. Examples of locations of a source of a request include a geographical location, a network address, or a machine cookie associated with a device sending the request. Locations of the request are compared with stored safe locations associated with the user account and a suspiciousness index is determined for the session. The level of authentication required for the session is determined based on the suspiciousness index. Locations are associated with a reputation based on past history of sessions originating from the locations. A location associated with a history of creating suspicious session is considered an unsafe location. Reputation of the location originating the session is used to determine the level of authentication required for the session.

Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.

Abstract: A method of determining the compatibility of respective information associated with at least two parties is described.

Abstract: The present invention concerns a process for making a polyareneazole multifilament yarn comprising: a) extruding a solution comprising polyareneazole polymer and polyphosphoric acid through a plurality of orifices to produce filaments; b) forming a multifilament yarn from said filaments; c) hydrolyzing at least some of the polyphosphoric acid in the yarn by heating the yarn to a temperature above about 120° C. for up to about two minutes; d) washing at least some of the hydrolyzed polyphosphoric acid from the yarn; e) drying the washed yarn; f) optionally, heating the yarn above about 300° C., and g) collecting the yarn at a speed of at least about 50 meters per minute.

Abstract: The present invention relates to a layered structure assembly (1) for a DC to AC inverter comprising: a first layered structure (10) with first (12) and second (13) conductive layers, a second layered structure (14) with third (16) and fourth (17) conductive layers, and at least one connector (21) providing a low resistance/inductance interconnection between layered structures (10, 14), the connecter (21) comprising a rod (23) inside a sleeve (26).

Abstract: The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.

Abstract: The disclosure describes systems and methods of ranking user interest in physical entities based on the attention given to those entities as determined by an analysis of communications from devices over multiple communication channels. The attention ranking systems allow any “Who, What, When, Where” entity to be defined and ranked based, at least in part, on information obtained from communications between users and user proxy devices. An entity rank is generated for entity known to the system in which the entity rank is derived from the information in communications that are indicative of user actions related to the entity. The entity ranks are then used to modify the display of information or data associated with the entities. The system may also generate a personal rank for each entity based on the relation of the entity to a specified user.

Abstract: Transactional memory compatibility type attributes are associated with intermediate language code to specify, for example, that intermediate language code must be run within a transaction, or must not be run within a transaction, or may be run within a transaction. Attributes are automatically produced while generating intermediate language code from annotated source code. Default rules also generate attributes. Tools use attributes to statically or dynamically check for incompatibility between intermediate language code and a transactional memory implementation.

Abstract: A system and method for facilitating acquisition of automotive core parts from automotive recyclers for remanufacture includes identifying automotive cores and determining the value of the cores with a core fulfillment system. The core fulfillment system includes an interchange database with automotive core descriptions and corresponding interchange identification indicators. The system includes a core supplier database that includes automotive core descriptions with corresponding core supplier identification indicators and an interchange number matching module that equates database entries in the interchange database with database entries in the core supplier database. An interface module provides access to the core fulfillment system, accepts vehicle information, and provides demand and pricing information regarding automotive cores.

Abstract: A method for targeted advertisement is provided, for which one or more tags relating to an advertisement is/are accessed, one or more of the most representative activities for the tag(s) is/are determined, and the advertisement is targeted to the one or more most representative activities. In addition, for each of a plurality of tags, one or more of the most representative activities is/are determined based on term frequency-inverse document frequency, such that an activity is relatively more representative of a tag if the tag is more uniquely and/or frequently associated with the activity. The advertisement is delivered to participants of the activities, and optionally during a time interval relevant to the activities.

Abstract: A method for ranking entities with respect to a tag for targeted advertisement is provided. For each entity to be ranked, a first score is calculated, which indicates the level of uniqueness the tag is to the entity. For each entity to be ranked, a second score is calculated, which indicates the number of people connected with the entity. For each entity to be ranked, a final score is calculated, which combines the first score and the second score. The entities are ranked based on their respective final scores. Optionally, the entity rankings may be used to determine the cost of advertisement for each entity and to recommend entities with respect to an advertisement.

Abstract: A user interface for targeted advertisement is provided, which comprises a plurality of interface components, wherein selected ones of the plurality of interface components are capable of: receiving a list of advertising targets; presenting a list of most representative entities for the list of advertising targets, wherein an entity is relatively more representative of an advertising target if the advertising target is relatively more uniquely and frequently associated with the entity; receiving a list of target entities selected from the list of most representative entities; and presenting an estimated advertising cost for the list of target entities.

Abstract: A method for targeted advertisement is provided, for which one or more tags relating to an advertisement is/are determined, one or more of the most representative entities for the tag(s) is/are determined, and the advertisement is targeted to the one or more most representative entities. In addition, for each of a plurality of tags, one or more of the most representative entities is/are determined based on term frequency-inverse document frequency, such that an entity is relatively more representative of a tag if the tag is more uniquely and/or frequently associated with the entity. For each tag, the associated entities may be divided into multiple categories, such that one or more most representative entities within each category is/are determined for each tag.

Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxyg

Abstract: An integrated circuit 2 includes a transaction master 4 connected via interconnect circuitry 10 to a transaction slave 12. The transaction slave 12 generates a transfer-complete signal (R Last or B) to indicate completion of a data transfer (either a read or a write). When this transfer-complete signal has been received by the transaction master 4, then the transaction master 4 generates a complete-acknowledgement signal RACK, WACK, which is passed back to the transaction slave so as to acknowledge receipt of the transfer-complete signal.

Abstract: Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.

Abstract: A system and method for automated service recommendations. A request is received over a network, from a user for service recommendations, wherein the request comprises an identification of the user and at least one service selection criteria. A query is formulated so as to search, via the network, for user profile data, spatial data, temporal data, social data and topical data that is available via the network and relates to the requesting user, the service selection criteria and to a plurality of services available via the network so as to a identify a subset of the plurality of services available via the network that relate to the request. A list of the identified subset of services is transmitted, via the network, to the requesting user. A selection of at least one of the selected subset of services available received from the user and the user is enrolled in the selected service.

Abstract: The invention provides a compound for use in medicine, the compound being a compound of the formula (VI0) or a salt, solvate, tautomer or N-oxide thereof: wherein the bicyclic group: is selected from the structures C1, C5 and C6: wherein n is 0, 1, 2 or 3; R1 is hydrogen, hydroxy, or O—Rz; R2a is hydroxy, methoxy or O—Rz; provided that at least one of R1 and R2a is O—Rz; Rz is Lp-Rp1; SO3H; a glucuronide residue; a mono-, di- or tripeptide residue; or Lp is a bond, C?O, (C?O)O, (C?O)NRp1 or S(O)xNRp1; x is 1 or 2; Rp1 is hydrogen or a an optionally substituted C1-25 hydrocarbyl group containing 0, 1 or 2 carbocyclic rings and 0, 1, 2, 3, 4, 5 or 6 carbon-carbon multiple bonds, provided that Rp1 is not hydrogen when Lp is a bond, C?O or (C?O)O; and provided also that O—Rz does not contain an O—O moiety; and excluding compounds wherein R1 is hydroxy and R2a is methoxy; Rp2 and Rp3 are the same or different and each is a group Rp1; and R3, R4a, R8 and R10 are defined in the claims.

Abstract: A recessed light fixture has vertical tilt and horizontal rotation adjustments recessed radially outwardly from a trim aperture defining ring for a cleaner aspect of the lamp aperture. A lamp holder is reachable through the trim aperture for manually returning the lamp holder from a tilted position to a vertical position and is releasable downward from the fixture for relamping in response to manual pulling force. A mechanical memory returns the lamp holder to the initial tilted position upon reinsertion of the lamp holder and release of the manual pulling force. The lamp fixture can be miniaturized to a size of about 2.5 inches in diameter and sized to fit in a ceiling cutout of about 3.5 inches in diameter.

Abstract: The present invention provides a method for preparing nanoparticles of group IV elements, particularly nanoparticles of Si, Ge and Sn, and binary and ternary alloys of these elements. The method comprises the solution-phase decomposition of one or more group IV metal precursors at elevated temperature and under an inert atmosphere at atmospheric pressure, using a decomposition-promoting reagent. A surface-bonding agent is added to the reaction mixture to form an organic layer surrounding the nanoparticles and prevent aggregation.