Patents by Inventor Christopher A. Yallop

Christopher A. Yallop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cultures of E1-immortalized cells and processes for culturing the same to increase product yields therefrom
    Patent number: 8008043
    Abstract: Provided are processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, such as PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant antibodies.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: August 30, 2011
    Assignee: Crucell Holland B.V.
    Inventor: Christopher A. Yallop
  • Cultures of E1-immortalized cells and processes for culturing the same to increase product yields therefrom
    Publication number: 20100311160
    Abstract: Provided are processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, such as PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant antibodies.
    Type: Application
    Filed: July 26, 2010
    Publication date: December 9, 2010
    Applicant: Crucell Holland B.V.
    Inventor: Christopher A. Yallop
  • COMPLEMENTATION OF FACTOR XI DEFICEINCY BY FACTOR V MUTANTS
    Publication number: 20100144620
    Abstract: Described are methods for preventing and/or treating bleeding in a subject with Factor XI deficiency, such as hemophilia C, which methods comprise administering to the subject APC-resistant Factor V.
    Type: Application
    Filed: November 15, 2007
    Publication date: June 10, 2010
    Applicant: Crucell Holland B.V.
    Inventors: Ingrid Van Den Nieuwenhof, Josephus C. M. Meijers, Christopher A. Yallop
  • Fed-batch process for production of erythropoietin in human embryonic retina cells that express adenovirus E1A
    Patent number: 7608431
    Abstract: The invention provides processes for recombinant production of erythropoietin (EPO) in a human embryonic retina cell that expresses at least an adenoviral E1A protein, wherein said EPO is produced at high concentrations and wherein said EPO as produced has a high average sialic acid content per EPO molecule.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: October 27, 2009
    Assignee: Crucell Holland B.V.
    Inventor: Christopher A. Yallop
  • Processes for culturing E1-immortalized cells to increase product yields
    Patent number: 7291484
    Abstract: The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® (human embryonic retina) cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant antibodies.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: November 6, 2007
    Assignee: Crucell Holland B.V.
    Inventor: Christopher A. Yallop