Abstract: The disclosure herein provides compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) for killing cancer cell or inhibiting cancer cell proliferation. Further, the compounds and pharmaceutical compositions of Formula (I), (II), (III), (IV), (V), or (VI) are useful in methods of for the inhibition of cancer cell proliferation.

Abstract: Described herein are methods for methods for extracting earth elements from rare earth element sources. In one aspect, the rare earth element source includes clayey materials present in coal and coal by-products, where one or more rare earth elements are adsorbed on the clayey materials. The methods involve admixing the rare earth element source with a base and an electrolyte composition. In one aspect, the electrolyte composition includes a chelating agent and/or a complexing agent. The extraction process is conducted at temperatures less than or equal to 100° C., which makes the process cost-effective and sustainable.

Abstract: Various examples are provided in relation to improved recovery and throughput of both fine and coarse particulate materials. In one example, a method includes injecting an aqueous suspension of a cloud of small air bubbles into an aqueous phase including fine particulate materials, wherein the fine particulate material is selectively hydrophobized and collected by small air bubbles; allowing the bubbles to rise in the aqueous phase; and collecting the air bubbles to obtain a concentrate of the fine particulate materials. In another example, a method includes adding a hydrophobizing agent to an aqueous phase to render coarse particulate material selectively hydrophobic; allowing air bubbles to attach to the coarse particulate material and changing the apparent specific gravity of the coarse particulate materials so a layer of one type of coarse particle is formed on top; allowing the one type of coarse particles to float and enter the forth phase.

Abstract: The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.

Abstract: A respiratory mask system includes a mask interface and a headgear assembly. The headgear assembly is adjustable and comprised of an elastic portion, a non-elastic portion and a restriction mechanism configured to provide a force resisting movement of the non-elastic portion when the elastic portion is extended. There is a support beam coupled to the non-elastic portion and extending along a portion of the headgear that is curved along its longitudinal extent. In this way particular seal modules can be comfortably fitted to a user and any blow off force is mitigated. A particular example of the respiratory mask system includes provision for removable attachment between the seal and a mask frame, the mask frame and a yoke of the headgear; and between a conduit and the mask frame.

Abstract: This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRISPR systems. The resultant length-modified and chemically-modified forms of crRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRIPSR Cas9 endonuclease system.

Abstract: This invention pertains to isolated mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays a lower ratio of reduced off-target editing activity to on-target editing activity for at least one target site relative to the corresponding ratio of reduced off-site editing activity to on-target editing activity of a wild-type CRISPR/Cas endonuclease system having a WT-Cas9 protein of SEQ ID NO:5.

Abstract: Systems, methods, and apparatuses for managing and controlling movable barrier operator systems are described herein. A method for controlling a movable barrier operator system comprises receiving a credential associated with a first user account from a first user device, storing the credential in a memory of the movable barrier operator system, communicating the credential and an identifier of the movable barrier operator system to a remote computer to register the movable barrier operator system with the remote computer, and configuring the movable barrier operator system to change a state of a movable barrier in response to the movable barrier operator system receiving a state change request from a second user device associated with a second user account, the state change request from the second user device including the credential or a derivative of the credential received from the first user device.

Abstract: In a system including vector registers storing right-hand side data and left-hand side data, first and second matrix staging registers, and a systolic array of processing cells for conducting matrix multiplication operations using the right-hand side data and left-hand side data, one or more processors load the right-hand side data from the vector registers to the first matrix staging register based on an instruction indicating whether to transpose the right-hand side data, load the left-hand side data from the vector registers into the second matrix staging register based on another instruction indicating whether to transpose the left-hand side data, load the right-hand side data from the first matrix staging register into the systolic array, and, in a cycle of the matrix multiplication operation, pass one or more columns of the left-hand side data from the second matrix staging register to a column of the systolic array.

Abstract: In a system including vector registers storing right-hand side data and left-hand side data, first and second matrix staging registers, and a systolic array of processing cells for conducting matrix multiplication operations using the right-hand side data and left-hand side data, one or more processors load the right-hand side data from the vector registers to the first matrix staging register based on an instruction indicating whether to transpose the right-hand side data, load the left-hand side data from the vector registers into the second matrix staging register based on another instruction indicating whether to transpose the left-hand side data, load the right-hand side data from the first matrix staging register into the systolic array, and, in a cycle of the matrix multiplication operation, pass one or more columns of the left-hand side data from the second matrix staging register to a column of the systolic array.

Abstract: A circuit for performing neural network computations for a neural network comprising a plurality of layers, the circuit comprising: activation circuitry configured to receive a vector of accumulated values and configured to apply a function to each accumulated value to generate a vector of activation values; and normalization circuitry coupled to the activation circuitry and configured to generate a respective normalized value from each activation value.

Abstract: First image data including a plurality of values representing the image in one or more first spectral bands of an electromagnetic spectrum is received. Second image data including a plurality of values representing the image in one or more second spectral bands of the electromagnetic spectrum is determined based on the first image data. The one or more second spectral bands of the electromagnetic spectrum include at least one spectral band not included in the one or more first spectral bands of the electromagnetic spectrum. The second image data is stored in a memory and/or provided to a user device for displaying the image in one or more second bands of the electromagnetic spectrum to a user of the user device.

Abstract: A crossover bumper for damping noise in a dual-spring shock absorber that includes a spring coupler and a crossover ring. The crossover bumper includes a first ring having a first material forming a ring-shaped body that includes a first side and a second side facing opposite to the first side, and that defines a central opening, an inside diameter and an outside diameter; and a second ring attached to the first side of the first ring and including a second material forming a ring-shaped body defining a central opening aligned with the central opening of the first ring, an inside diameter and an outside diameter. The first material has a modulus of elasticity that is greater than a modulus of elasticity of the second material.

Abstract: A system and method for matrix multiplication using a systolic array configurable between multiple modes of operation. A systolic processor may receive a data type indicator for the matrix multiplication. For a first data type, the systolic processor may load the right-hand side data from the right-hand matrix register into the data processing cells of the systolic array between row 0 and row M?1, and pass the respective row of the left-hand side data through a corresponding row of the systolic array between rows 0 and M?1. For a second data type, the systolic processor may split each element of the left-hand side data and the right-hand side data into respective first and second element halves, and move each element half through a corresponding row of the systolic array between rows 0 and 2M?1.

Abstract: A circuit comprises an input register configured to receive an input vector of elements, a control register configured to receive a control vector of elements, wherein each element of the control vector corresponds to a respective element of the input vector, and wherein each element specifies a permutation of a corresponding element of the input vector, and a permute execution circuit configured to generate an output vector of elements corresponding to a permutation of the input vector. Generating each element of the output vector comprises accessing, at the input register, a particular element of the input vector, accessing, at the control register, a particular element of the control vector corresponding to the particular element of the input vector, and outputting the particular element of the input vector as an element at a particular position of the output vector that is selected based on the particular element of the control vector.

Abstract: A circuit for performing neural network computations for a neural network comprising a plurality of layers, the circuit comprising: activation circuitry configured to receive a vector of accumulated values and configured to apply a function to each accumulated value to generate a vector of activation values; and normalization circuitry coupled to the activation circuitry and configured to generate a respective normalized value from each activation value.

Abstract: A process of evaluating whether to open a new car wash at a new geographic location includes establishing the geographic location for consideration, obtaining real-time data generated for a plurality of existing car washes at or near the geographic location, and categorizing the real-time data obtained for each of the existing car washes into a plurality of defined categories. A data structure linking the real-time data obtained with unique location identifiers is generated, and demographic information is accessed for the respective locations using the location identifiers. An artificial neural network generates a financial prediction indicating an expected financial performance of the car wash if constructed at the geographic location based on the data structure. A determination can be made whether to construct the new wash at the geographic location based on whether an expected financial performance of the car wash at the geographic location satisfies a minimum performance threshold.

Abstract: Backpack strap accessory methods, systems, and device are provided in accordance with various embodiments. Some embodiments include a device that may include a backpack accessory. The device may include one or more attachment appendages coupled with the backpack accessory where the one or more attachment appendages are configured to couple the backpack accessory with a backpack shoulder strap. The device may include one or more rigid members coupled with the backpack accessory such that at least one of the rigid members hinder a motion of the backpack accessory in at least one direction along a length of the backpack shoulder strap with respect to a hardware coupled with the backpack shoulder strap. Some embodiments include one or more apertures formed with respect to the attachment appendages such that a sternum strap coupled with the backpack shoulder strap passes through at least one of the one or more apertures.

Abstract: A containment plow adapted to be mounted to a vehicle such as a skid steer, a wheeled loader, or a tractor, comprises a moldboard frame, a moldboard mounted to the moldboard frame, a moldboard cutting edge mounted to a lower edge of the moldboard and comprising a plurality of cutting edge segments, each moldboard cutting edge segment mounted so as to have two rotational degrees of freedom movement relative to the moldboard and one translational degree of freedom movement relative to the moldboard, and a moldboard extension and wing assembly connected to the moldboard frame adjacent each end of the moldboard.