Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, an anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.

Abstract: Implementations are directed to obtaining a plurality of item profiles for a plurality of new items, each item profile comprising a set of attributes for a respective new item; for each new item: selecting one or more existing items that are similar to the new item based on item attributes of the existing items and the set of attributes of the new item, and executing a collaborative filtering model to determine a first score for the new item based on historical user interactions with the one or more existing items; determining a second score for each new item using an adaptive model; and outputting a first set of new items based on the first score, and a second set of new items based on the second score, an initial ratio between the first set of new items and the second set of new items is a predetermine value.

Abstract: The present invention provides compositions and methods for treating diseases and disorders associated with premature termination codons comprising administration of nucleic acid molecules comprising or encoding anticodon edited tRNAs.

Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.

Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.