Abstract: A portable cooler container is provided. The temperature control system cools a chamber of the container to transport temperature sensitive contents via the container. An electronic display screen on one of the lid and the container body selectively displays an electronic shipping label for the portable cooler container.

Abstract: Disclosed is a strip lighting system that receives lighting control signals digitally over a conductor which also provides power to the strip lighting system. The strip lighting system includes a controller which receives the control signals operates switches which cause current to flow through one or more light emitting diodes and also a non-lighting load to permit the strip lighting system to have a constant load characteristic to a lighting system controller controlling the strip lighting system.

Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: A wound therapy system having a wound dressing for treating a wound includes a sensor that measures a pH level at a wound area. The sensor has a circuit that includes a first electrode and one or more second electrodes. The first electrode has a changeable conductivity that changes according to a hydrogen ion concentration level. The one or more second electrodes are configured with a fixed conductivity that does not change with the hydrogen ion concentration level. The first electrode is coated with a porous protective membrane formed from a sulfonated and/or carboxylated copolymer.

Abstract: A container with active temperature control system is provided. The active temperature control system is operated to heat or cool a chamber sized to receive a beverage therein. The container includes an insulated vessel that has the chamber and a cooling or heating unit. The cooling or heating unit includes a thermoelectric element in thermal communication with the chamber, phase change material in thermal communication with the thermoelectric element, a power storage device, and circuitry to control the operation of the thermoelectric element. The cooling or heating unit is operable to increase or decrease or maintain a temperature of the beverage in the chamber by operating the thermoelectric element to draw heat from the chamber and transfer it to the module of phase change material.

Abstract: Systems and methods for sender profile and/or recipient profile disambiguation and/or confirmation are disclosed. In instances where a sender profile is not indicated by a user sending a communication from a communal device, heuristic data may be utilized to infer the sender profile. Similar heuristic data may also be used when selection of the sender profile is associated with a low confidence level. Heuristic data may also be used to infer the recipient profile when the user does not indicate the recipient profile or when selection of the recipient profile is associated with a low confidence. Various confirmations may result from the sender and recipient profile disambiguation.

Abstract: A negative pressure wound therapy system includes at least one sensor coupled to a wound dressing for a wound of a patient, and a control circuit. The at least one sensor is configured to output an indication of a displacement of the wound dressing. The control circuit is configured to receive the indication of the displacement of the wound dressing, calculate a therapy parameter corresponding to the indication of the displacement, and output the therapy parameter.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: An actively heated drinkware container includes a vessel with a chamber that receives and holds a volume of liquid. The drinkware container includes a heating module with a first heating element operable to heat one portion of the chamber and a second heating element operable to heat another portion of the chamber, the second heating element spaced from the first heating element. Operation of the first and second heating elements generates a circulation current in the volume of liquid in the chamber that mixes the liquid and diffuses a temperature of the liquid to thereby reduce temperature stratification of the liquid in the chamber and so that a temperature of the liquid throughout the volume of liquid in the chamber is approximately uniform.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

Abstract: Systems, apparatuses, and methods for providing negative pressure and/or instillation fluids to a tissue site. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure and/or therapeutic solution of fluids to a tissue site, which can be used in conjunction with sensing properties of fluids extracted from a tissue site and/or instilled at a tissue site. For example, an apparatus includes a dressing interface or connector that includes a pH sensor, a humidity sensor, a temperature sensor and/or a pressure sensor embodied on a single pad within the connector and proximate the tissue site to provide data indicative of acidity, humidity, temperature and pressure. Such apparatus includes algorithms for processing such data for detecting leakage and blockage as well as providing information relating to the progression of healing of wounds at the tissue site.

Abstract: An example of a pixel module comprises a module substrate having light emitters disposed on a light-emitter surface and a controller disposed on a controller surface opposed to the light-emitter surface. At least one module electrode is electrically connected to the controller and at least one module electrode is electrically connected to each light emitter. An example of a pixel-module wafer comprises a module source wafer comprising sacrificial portions and module anchors, each sacrificial portion laterally separated from an adjacent sacrificial portion by a module anchor and a pixel module disposed entirely over each sacrificial portion. At least one module tether physically connects each of the pixel modules to at least one of the module anchors. An example of a pixel-module display comprises a display substrate, pixel modules disposed on the display substrate and display electrodes disposed on the display substrate, each display electrode electrically connected to a module electrode.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.

Abstract: Method and apparatuses for diffuse optical tomography (DOT) are disclosed herein. A DOT device includes a substrate, one or more radiation sources, a plurality of detectors, and structures disposed over the second surface of the plurality of detectors. The one or more radiation sources are disposed over or under a surface of the substrate. Each detector of the plurality of detectors has a first surface and a second surface. The first surface is opposite the second surface. The first surface of the plurality of detectors disposed over or under the surface of the substrate. The method of DOT method of includes emitting and scattering radiation from one or more sources of a DOT device; detecting scattered radiation with a plurality of detectors of the DOT device; and translating the scattered radiation that is detected into data.

Abstract: The present disclosure provides methods and compositions for controlling asphaltenes in a subterranean formation. The compositions may include a halloysite nanotube. The nanotube has a lumen and a polymer, along with a charged surfactant, may be disposed in the lumen. A wax may be disposed on the nanotube. The wax may be disposed at either or both ends of the nanotube, thereby temporarily preventing the polymer and charged surfactant from leaving the lumen.

Abstract: This disclosure describes devices, systems, and methods related to therapy devices including pumps that are operable in multiple operating modes. An exemplary wound therapy device includes a pump configured to be worn by a user and a controller coupled to the pump and configured to transition the pump from operating in a first operating mode to operating in a second operating mode responsive to a pressure of the wound therapy device satisfying a first pressure threshold. The first operating mode is associated with a first drive voltage that is different from a second drive voltage associated with the second operating mode.

Abstract: Provided herein is a system and method for mitigating premature light deactivation of light deactivated adhesive drapes. One aspect provides a system comprising a drape, a photosensitive adhesive layer, a release agent, and an optical fiber mesh layer configured as a light pipe, where the system is adapted to be coupled to a tissue site and released therefrom upon or after exposure to an external stimulus such as certain wavelengths of light. Another aspect includes a pipe light pipe, as an alternative to the optical fiber mesh layer. The systems may have a removable blocking layer to prevent the photosensitive adhesive from being exposed to deactivation wavelengths prematurely. Another aspect provides a method for application and removal of a drape using the light pipe to transport or route light to the drape to deactivate the photosensitive adhesive layer and promote easy, clean, and less painful removal of the drape.