Abstract: A vehicle wheel is defined by a substrate including a face and a rim portion. The face defines a plurality of spokes extending radially outwardly between a central portion of the face and the rim portion and defining a mating portion. An applique is affixed to the wheel at the mating portion. A polymer over-coating that is substantially transparent extends over the applique and the wheel substrate defining a continuous polymer surface over the applique and the wheel substrate.

Abstract: Described herein are methods for the expression and purification of Cas13a and methods for detecting target RNA using Cas13a.

Abstract: A storage, retrieval and processing system for processing objects is disclosed. The storage, retrieval and processing system includes a plurality of storage bins providing storage of a plurality of objects, where the plurality of storage bins is in communication with a retrieval conveyance system, a programmable motion device in communication with the retrieval conveyance system for receiving the storage bins from the plurality of bins, where the programmable motion device includes an end effector for grasping and moving a selected object out of a selected storage bin, and a movable carriage for receiving the selected object from the end effector of the programmable motion device, and for carrying the selected object to one of a plurality of destination bins.

Abstract: An interchangeable electro-mechanical lock core for use with a lock device having a locked state and an unlocked state is disclosed. The interchangeable electromechanical lock core may include a moveable plug having a first position relative to a lock core body which corresponds to the lock device being in the locked state and a second position relative to a lock core body which corresponds to the lock device being in the unlocked state.

Abstract: Systems and methods for dynamically generating federated application programming interfaces (APIs) are disclosed. Network components, such as servers and other devices, transmit and receive electronic communications according to standards and protocols native to those network components. Aspects of the present system detect those native standards and furthermore generate a federated API that allows for the content of the electronic communications to be represented in a universal format. Accordingly, the universal format may be used for network communications between system components and modules that may not have otherwise been compatible to receive the communications, and furthermore the communications may be transformed back to their respective native formats upon reaching their destinations. The present system generates models for representing these APIs, where instances of the models may be instantiated for particular API calls, as detected.

Abstract: A variety of applications can include apparatus having p-channel metal-oxide-semiconductor (PMOS) transistors and n-channel metal-oxide-semiconductor (NMOS) transistors with different metal silicide contacts. The active area of the NMOS transistor can include a first metal silicide having a first metal element, where the first metal silicide is a vertical lowest portion of a contact for the NMOS. The PMOS transistor can include a stressor source/drain region to a channel region of the PMOS transistor and a second metal silicide directly contacting the stressor source/drain region without containing the first metal element. The process flow to form the PMOS and NMOS transistors can enable making simultaneous contacts by a pre-silicide in the active area of the NMOS transistor, without affecting stressor source/drain regions in the PMOS transistor. The process flow and resulting structures for PMOS transistors and NMOS transistors can be used in various integrated circuits and devices.

Abstract: A component for a vehicle interior may comprise a light guide to allow light transmission from a light source for a user interface, and a cover to cover the light guide. The user interface may be presented at the cover. The cover may comprise a depression in an inner surface of the cover and the light guide may comprise a projection comprising a light-transmissive resin fit within the depression. The projection may comprise an icon to be presented at the user interface when illuminated, and to be hidden by the cover when not illuminated. The user interface may comprise a light display and an input device connected to a sensor. The icon may comprise an image. The cover thickness may be greater than the projection height. The component may comprise a steering wheel, console, floor console, center console, instrument panel, door panel, dashboard, display, armrest, or cockpit.

Abstract: An exemplary compounding method of controlling a compounding device to prepare an admixture of at least two distinct material sources can include examining material source solutions for incompatibility of the ingredients and operating a first and a second pump to prevent one of the incompatible source solutions from entering a common flow path. The processing method can detect degradation of a fluid line by evaluating one or more of calibration error rate data, cumulative volumetric flow data, or cumulative pump operation data. The processing method can also selectively transfer a first group of source solutions using the first pump, receiving pump data from one or more sensors that sense actions of the pumps, applying fluid correction factors and calculating discrete pump movements, the pump movements being indicative of an amount of source solution displacement by a pump, and operating the pumps to selectively dispense the source solution amounts according to a preparation order.

Abstract: This invention pertains to mutant Cas9 nucleic acids and proteins for use in CRISPR/Cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant Cas9 protein, wherein the isolated mutant Cas9 protein is active in a CRISPR/Cas endonuclease system, wherein the CRISPR/Cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system. The invention also includes isolated nucleic acids encoding mutant Cas9 proteins, ribonucleoprotein complexes and CRSPR/Cas endonuclease systems having mutant Cas9 proteins that display reduced off-target editing activity and maintained on-target editing activity relative to a wild-type CRISPR/Cas endonuclease system.

Abstract: A striking hand tool includes a grip component where an external surface has a front arc half and a rear arc half, wherein an area of the grip is smaller in a first cross sectional plane further from a head of the tool than a second plane closer to the head portion. A ? value of the front arc half in the first cross sectional plane is less than approximately 0.45. A measurement from a first axis to a frontmost point in the first cross sectional plane is between 17.5 mm and 19 mm. A ? value of the front arc half in the second cross sectional plane is less than approximately 0.5. A measurement from the first axis to a frontmost point in the second cross sectional plane is between 18.5 mm and 20 mm. Methods of manufacturing and striking hand tools having desirous durometer measurements are also disclosed.

Abstract: A wearable computing device with bio-signal sensors and a feedback module provides an interactive mediated reality (“VR”) environment for a user. The bio-signal sensors receive bio-signal data (for example, brainwaves) from the user and include bio-signal sensors embedded in a display isolator, having a deformable surface, and having an electrode extendable to contact the user's skin. The wearable computing device further includes a processor to: present content in the VR environment via the feedback module; receive bio-signal data of the user from the bio-signal sensor; process the bio-signal data to determine user states of the user, including brain states, using a user profile; modify a parameter of the content in the VR environment in response to the user states of the user. The user receives feedback indicating the modification of the content via the feedback module.

Abstract: A training apparatus has an input device and a wearable computing device with a bio-signal sensor and a display to provide an interactive virtual reality (“VR”) environment for a user. The bio-signal sensor receives bio-signal data from the user. The user interacts with content that is presented in the VR environment. The user interactions and bio-signal data are scored with a user state score and a performance scored. Feedback is given to the user based on the scores in furtherance of training. The feedback may update the VR environment and may trigger additional VR events to continue training.

Abstract: A dressing that includes a contact layer having walls defining a plurality of holes and a retainer layer comprising portions protruding into holes of a contact layer is provided herein. Systems, methods and kits using the dressing for debriding a tissue site are also provided herein.

Abstract: Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned analyte sensor automatically or on demand upon request from a user.

Abstract: An infusion pump, including a housing, a user interface, a motor and a set of drive components, and a controller. The housing enables selective stacked attachment with other infusion pumps. The housing includes a top portion with a handle integrated into an outer surface that partially defines a generally U-shaped retaining feature. The housing also includes a bottom portion with a generally U-shaped projection that is contoured to selectively mate with the retaining feature of another infusion pump. The user interface provides a front side to the housing that receives commands regarding infusion pump operation. The motor and set of drive components are at least partially located within the housing and mechanically direct infusion of infusate. The controller is located within the housing and that controls operation of the motor and the set of drive components.

Abstract: Certain aspects relate to systems and techniques for manually and robotically driving a medical instrument. For example, a system can include a handle configured to receive an elongated shaft of a medical instrument. The handle can include a gripping mechanism for selectively engaging the elongated shaft, and an articulation input and configured for receiving user inputs of commanded articulation of the elongated shaft. The system can include an instrument drive mechanism configured to engage a base of the medical instrument. The instrument drive mechanism can include at least one robotic drive output configured to engage a robotic drive input of the base to cause articulation of the elongated shaft based on the user inputs received at the articulation input, and a first connector configured to removably couple the instrument drive mechanism to an instrument positioning device.

Abstract: A system and method may be provided for associating bio-signal data (e.g. EEG brain scan data) from at least one user with at least one music data item (e.g. song, or piece of music). By associating bio-signal data, or emotions determined therefrom, with music, the system may establish a data store of music associated with emotions. That database may then be leveraged upon determining that a user is feeling a particular emotion through an EEG scan. When a particular emotion is detected in EEG data of a user, the system may then respond based at least partly on the same or similar emotion being associated with one or more music data items in the system. For example, the system may recommend a particular song associated with the same emotion presently being experienced by the user.

Abstract: At a rule processing unit of an evolving, self-organized machine learning-based resource management service, a rule of a first rule set is applied to a value of a first collected metric, resulting in the initiation of a first corrective action. A set of metadata indicating the metric value and the corrective action is transmitted to a repository, and is used as part of an input data set for a machine learning model trained to generate rule modification recommendations. In response to determining that the corrective actions did not meet a success criterion, an escalation message is transmitted to another rule processing unit.

Abstract: Existing currency validation (CVAL) devices, systems, and methods are too slow, costly, intrusive, and/or bulky to be routinely used in common transaction locations (e.g., at checkout, at an automatic teller machine, etc.). Presented herein are devices, systems, and methods to facilitate optical validation of documents, merchandise, or currency at common transaction locations and to do so in an obtrusive and convenient way. More specifically, the present invention embraces a validation device that may be used alone or integrated within a larger system (e.g., point of sale system, kiosk, etc.). The present invention also embraces methods for currency validation using the validation device, as well as methods for improving the quality and consistency of data captured by the validation device for validation.

Abstract: Methods, systems, and circuitries are provided for detecting flame in a fuel oil burner. In one example, a method includes receiving a series of one or more light samples, each indicative of a level of light. When the fuel oil burner is operating in the flame expected mode, the method includes determining whether the values of the one or more of the light samples exceed a flame threshold; determining whether the values of the one or more of the light samples meet secondary criteria; determining that a flame is present when the values of the one or more light samples exceed the flame threshold and meet the secondary criteria; and determining that a flame is not present when the values of the one or more light samples are below the flame threshold or do not meet the secondary criteria.