Patents by Inventor Christopher Allender

Christopher Allender has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Early detection of drug-resistant mycobacterium tuberculosis
    Patent number: 12522877
    Abstract: The present invention relates to oligonucleotides, methods, and kits for detecting an antibiotic-resistant subpopulation within a heteroresistant population of Mycobacterium tuberculosis in a sample. An amplicon of a target locus is obtained from the sample. The target locus comprises a region of interest which comprises one or more minor variants associated with the antibiotic resistance. The target locus is selected from the group consisting of: Rv0678, pepQ, atpE, ddn, fbiA, fbiB, fbiC, fgd, fgd1, and fgd2. The region of interest is interrogated to detect the one or more minor variants and thus, the antibiotic-resistant subpopulation of M. tuberculosis.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: January 13, 2026
    Assignees: The Translational Genomics Research Institute, The Regents of the University of California for and on behalf of the San Francisco campus
    Inventors: David Engelthaler, Christopher Allender, James Schupp, John Metcalfe
  • EARLY DETECTION OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20220145366
    Abstract: The present invention relates to oligonucleotides, methods, and kits useful for detecting an antibiotic-resistant subpopulation within a heteroresistant population of Mycobacterium tuberculosis in a sample. An amplicon of a target locus is obtained from the sample. The target locus comprises a region of interest which comprises one or more minor variants associated with the antibiotic resistance. The target locus is selected from the group consisting of: pncA, tlyA, gidB, rpsL, gyrB, embB, ahpC promoter, rplC, and combinations thereof. The amplicon is sequenced on a Next Generation Sequencing (NGS) platform. The region of interest is interrogated to detect the one or more minor variants and thus, the antibiotic-resistant subpopulation of Mycobacterium tuberculosis.
    Type: Application
    Filed: June 17, 2021
    Publication date: May 12, 2022
    Inventors: David Engelthaler, Christopher Allender, James Schupp
  • EARLY DETECTION OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS
    Publication number: 20210395798
    Abstract: The present invention relates to oligonucleotides, methods, and kits for detecting an antibiotic-resistant subpopulation within a heteroresistant population of Mycobacterium tuberculosis in a sample. An amplicon of a target locus is obtained from the sample. The target locus comprises a region of interest which comprises one or more minor variants associated with the antibiotic resistance. The target locus is selected from the group consisting of: Rv0678, pepQ, atpE, ddn, fbiA, fbiB, fbiC, fgd, fgd1, and fgd2. The region of interest is interrogated to detect the one or more minor variants and thus, the antibiotic-resistant subpopulation of M. tuberculosis.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 23, 2021
    Inventors: David Engelthaler, Christopher Allender, James Schupp, John Metcalfe