Patents by Inventor Christopher B. Buck
Christopher B. Buck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220395569Abstract: Disclosed herein are methods of eliciting an immune response against a polyomavirus (for example, BKV serotype I (BKV-I), BKV serotype II (BKV-II), BKV serotype III (BKV-III) and/or BKV serotype IV (BKV-IV)) and methods of treating or inhibiting polyomavirus-associated pathology (such as polyomavirus-associated nephropathy, BKV-associated hemorrhagic cystitis, or JC virus-associated progressive multifocal leukoencephalopathy; PML). Further disclosed are immunogenic compositions of use in the disclosed methods. Also disclosed are methods of selecting an organ transplant donor and/or recipient including detecting whether the prospective donor and/or recipient has BKV serotype-specific (such as BKV serotype IV-specific) neutralizing antibodies.Type: ApplicationFiled: August 25, 2022Publication date: December 15, 2022Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human ServicesInventors: Christopher B. Buck, Diana V. Pastrana
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Publication number: 20190117760Abstract: The invention features immunogenic compositions and methods useful for eliciting an immune response. In preferred embodiments, papillomavirus or adenovirus vectors are used to elicit exceptionally potent antibody and T cells responses in disrupted epithelium. The methods are useful in preventing or treating a subject having a disease or an infection. In particular examples, the methods are useful for preventing or treating a viral infection.Type: ApplicationFiled: November 2, 2018Publication date: April 25, 2019Inventors: Barney S. Graham, Christopher B. Buck, Jeffrey N. Roberts, Teresa R. Johnson, John Nicewonger, Rhonda Kines, John T. Schiller
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Patent number: 9931393Abstract: Methods of eliciting an immune response to a JC polyomavirus (JCV) by administering an effective amount of an immunogenic composition including an isolated JCV VP1 polypeptide or a nucleic acid encoding the VP1 polypeptide to a subject are provided. VP1 polypeptides and immunogenic compositions suitable for use in the methods are provided, including JCV genotype 2 VP1 polypeptides and/or JCV genotype 3 polypeptides. Methods of identifying a subject at risk of developing progressive multifocal leukoencephalopathy (PML) are also provided. In some embodiments, the methods include obtaining a biological sample from a subject, detecting presence or absence of JCV neutralizing antibodies in the sample from the subject, and identifying that the subject is at risk of developing PML if there is an absence of detectable JCV neutralizing antibodies in the sample from the subject.Type: GrantFiled: December 19, 2014Date of Patent: April 3, 2018Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Christopher B. Buck, Upasana Ray, Diana V. Pastrana
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Publication number: 20170368163Abstract: Disclosed herein are methods of eliciting an immune response against a polyomavirus (for example, BKV serotype I (BKV-I), BKV serotype II (BKV-II), BKV serotype III (BKV-III) and/or BKV serotype IV (BKV-IV)) and methods of treating or inhibiting polyomavirus-associated pathology (such as polyomavirus-associated nephropathy, BKV-associated hemorrhagic cystitis, or JC virus-associated progressive multifocal leukoencephalopathy; PML). Further disclosed are immunogenic compositions of use in the disclosed methods. Also disclosed are methods of selecting an organ transplant donor and/or recipient including detecting whether the prospective donor and/or recipient has BKV serotype-specific (such as BKV serotype IV-specific) neutralizing antibodies.Type: ApplicationFiled: September 1, 2017Publication date: December 28, 2017Applicant: The United States of America, as represented by the Secretary, Dept. of Health and Human ServicesInventors: Christopher B. Buck, Diana V. Pastrana
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Patent number: 9764022Abstract: Disclosed herein are methods of eliciting an immune response against a polyomavirus (for example, BKV serotype I (BKV-I), BKV serotype II (BKV-II), BKV serotype III (BKV-III) and/or BKV serotype IV (BKV-IV)) and methods of treating or inhibiting polyomavirus-associated pathology (such as polyomavirus-associated nephropathy, BKV-associated hemorrhagic cystitis, or JC virus-associated progressive multifocal leukoencephalopathy; PML). Further disclosed are immunogenic compositions of use in the disclosed methods. Also disclosed are methods of selecting an organ transplant donor and/or recipient including detecting whether the prospective donor and/or recipient has BKV serotype-specific (such as BKV serotype IV-specific) neutralizing antibodies.Type: GrantFiled: July 17, 2012Date of Patent: September 19, 2017Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Christopher B. Buck, Diana V. Pastrana
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Publication number: 20160317643Abstract: Disclosed herein are methods of eliciting an immune response to a JC polyomavirus (JCV) by administering an effective amount of an immunogenic composition including an isolated JCV VP1 polypeptide or a nucleic acid encoding the VP1 polypeptide to a subject. VP1 polypeptides and immunogenic compositions suitable for use in the methods are disclosed herein, including JCV genotype 2 VP1 polypeptides and/or JCV genotype 3 polypeptides. Also disclosed are methods of identifying a subject at risk of developing progressive multifocal leukoencephalopathy (PML). In some embodiments, the methods include obtaining a biological sample from a subject, detecting presence or absence of JCV neutralizing antibodies in the sample from the subject, and identifying that the subject is at risk of developing PML if there is an absence of detectable JCV neutralizing antibodies in the sample from the subject.Type: ApplicationFiled: December 19, 2014Publication date: November 3, 2016Applicant: The United States of America, as represented by The Secretary, Dept. of Health and Human ServicesInventors: Christopher B. BUCK, Upasana RAY, Diana V. PASTRANA
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Publication number: 20140154284Abstract: Disclosed herein are methods of eliciting an immune response against a polyomavirus (for example, BKV serotype I (BKV-I), BKV serotype II (BKV-II), BKV serotype III (BKV-III) and/or BKV serotype IV (BKV-IV)) and methods of treating or inhibiting polyomavirus-associated pathology (such as polyomavirus-associated nephropathy, BKV-associated hemorrhagic cystitis, or JC virus-associated progressive multifocal leukoencephalopathy; PML). Further disclosed are immunogenic compositions of use in the disclosed methods. Also disclosed are methods of selecting an organ transplant donor and/or recipient including detecting whether the prospective donor and/or recipient has BKV serotype-specific (such as BKV serotype IV-specific) neutralizing antibodies.Type: ApplicationFiled: July 17, 2012Publication date: June 5, 2014Applicant: The United States of America,as represented by the Secretary Department of Health & Human ServicesInventors: Christopher B. Buck, Diana V. Pastrana
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Publication number: 20110091496Abstract: The invention features immunogenic compositions and methods useful for eliciting an immune response. In preferred embodiments, papillomavirus or adenovirus vectors are used to elicit exceptionally potent antibody and T cells responses in disrupted epithelium. The methods are useful in preventing or treating a subject having a disease or an infection. In particular examples, the methods are useful for preventing or treating a viral infection.Type: ApplicationFiled: January 21, 2009Publication date: April 21, 2011Inventors: Barney S. Graham, Christopher B. Buck, Jeffrey N. Roberts, Teresa R. Johnson, John Nicewonger, Rhonda Kines, John T. Schiller
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Patent number: 6736591Abstract: A hopper loading system for a pallet making apparatus includes a first conveying system for conveying a layer of stringers from a stacked array in adjacent substantially horizontal relation along a first direction, and a second conveying system for conveying stringers in adjacent substantially horizontal relation to one of a plurality of hoppers along a second direction substantially transverse to the first direction.Type: GrantFiled: October 5, 2001Date of Patent: May 18, 2004Assignee: Libla IndustriesInventor: Christopher B. Buck
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Patent number: 6430800Abstract: An apparatus for making pallets includes an automatic stringer feeding system; an automatic stringer advancing system; a pallet assembly station; a nail delivery system; and a pallet stacking system. Wood stringers are automatically fed to a series of hoppers which facilitate advancing the stringers into the pallet assembly station. Spaced apart deck boards are nailed, via a gantry movable along a longitudinally extending frame on generally parallel spaced apart linear guide bearings, to both sides of the supporting base of transversely positioned stringers in the pallet assembly station. Multiple nailing stations in adjacent spaced relationship include a pneumatically driven double ram for nailing together stringers and overlying deck boards positioned within the pallet assembly station.Type: GrantFiled: March 19, 1997Date of Patent: August 13, 2002Assignee: Libla IndustriesInventor: Christopher B. Buck
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Publication number: 20020104210Abstract: An apparatus for making pallets includes an automatic stringer feeding system; an automatic stringer advancing system; a pallet assembly station; a nail delivery system; and a pallet stacking system. Wood stringers are automatically fed to a series of hoppers which facilitate advancing the stringers into the pallet assembly station. Spaced apart deck boards are nailed, via a gantry movable along a longitudinally extending frame on generally parallel spaced apart linear guide bearings, to both sides of the supporting base of transversely positioned stringers in the pallet assembly station. Multiple nailing stations in adjacent spaced relationship include a pneumatically driven double ram for nailing together stringers and overlying deck boards positioned within the pallet assembly station.Type: ApplicationFiled: October 5, 2001Publication date: August 8, 2002Inventor: Christopher B. Buck