Patents by Inventor Christopher B. Darrow
Christopher B. Darrow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6750311Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.Type: GrantFiled: December 14, 1999Date of Patent: June 15, 2004Assignees: MiniMed Inc., The Regents of the University of CaliforniaInventors: William Peter Van Antwerp, John Joseph Mastrototaro, Stephen M. Lane, Joe H. Satcher, Jr., Christopher B. Darrow, Thomas A. Peyser, Jennifer Harder
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Patent number: 6682938Abstract: An analyte sensing fluorescent molecule that employs intramolecular electron transfer is designed to exhibit selected fluorescent properties in the presence of analytes such as saccharides. The selected fluorescent properties include excitation wavelength, emission wavelength, fluorescence lifetime, quantum yield, photostability, solubility, and temperature or pH sensitivity. The compound comprises an aryl or a substituted phenyl boronic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. The fluorophore and switch component are selected such that the value of the free energy for electron transfer is less than about 3.0 kcal mol−1. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin.Type: GrantFiled: September 15, 2000Date of Patent: January 27, 2004Assignees: The Regents of the University of California, Minimed Inc.Inventors: Joe H. Satcher, Jr., Stephen M. Lane, Christopher B. Darrow, Douglas R. Cary, Joe Anh Tran
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Patent number: 6673625Abstract: The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds.Type: GrantFiled: March 30, 2001Date of Patent: January 6, 2004Assignees: The Regents of the University of California, MiniMed Inc.Inventors: Joe H. Satcher, Jr., Stephen M. Lane, Christopher B. Darrow, Douglas R. Cary, Joe Anh Tran
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Patent number: 6480730Abstract: An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.Type: GrantFiled: December 20, 2000Date of Patent: November 12, 2002Assignee: The Regents of the University of CaliforniaInventors: Christopher B. Darrow, Joe H. Satcher, Jr., Stephen M. Lane, Abraham P. Lee, Amy W. Wang
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Publication number: 20020043651Abstract: The invention disclosed herein provides fluorescence based methods for the determination of polyhydroxylated analyte concentrations as well as optical polyhydroxylate analyte sensors and sensor systems. In particular, the invention provides methods of quantifying the abundances or concentrations of polyhydroxylate analyte by measuring changes in the fluorescence lifetimes. The methods of the invention are based on the observation that fluorescent sensor molecules capable of binding a polyhydroxylated analyte such as glucose have distinct fluorescent lifetimes depending upon whether they are in a form that is either bound to analyte or a form that is not bound to the analyte. The distinct and measurable differences in the fluorescence lifetimes of the different fluorescent sensor species can be used to determine the relative abundance of the bound and unbound fluorescent sensor species, a parameter which can then be correlated to the concentration of the analyte.Type: ApplicationFiled: April 4, 2001Publication date: April 18, 2002Inventors: Christopher B. Darrow, Joe H. Satcher, Stephen M. Lane, Jennifer Harder Gable
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Publication number: 20020010279Abstract: The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds.Type: ApplicationFiled: March 30, 2001Publication date: January 24, 2002Inventors: Joe H. Satcher, Stephen M. Lane, Christopher B. Darrow, Douglas R. Cary, Joe Anh Tran
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Publication number: 20010016683Abstract: An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.Type: ApplicationFiled: December 20, 2000Publication date: August 23, 2001Inventors: Christopher B Darrow, Joe H. Satcher, Stephen M. Lane, Abraham P. Lee, Amy W. Wang
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Patent number: 6201980Abstract: An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.Type: GrantFiled: October 5, 1998Date of Patent: March 13, 2001Assignee: The Regents of the University of CaliforniaInventors: Christopher B. Darrow, Joe H. Satcher, Jr., Stephen M. Lane, Abraham P. Lee, Amy W. Wang
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Patent number: 6002954Abstract: Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.Type: GrantFiled: November 21, 1996Date of Patent: December 14, 1999Assignees: The Regents of the University of California, Minimed Inc.Inventors: William Peter Van Antwerp, John Joseph Mastrototaro, Stephen M. Lane, Joe H. Satcher, Jr., Christopher B. Darrow, Thomas A. Peyser, Jennifer Harder