Patents by Inventor Christopher B. FOX
Christopher B. FOX has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11801223Abstract: The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.Type: GrantFiled: December 29, 2014Date of Patent: October 31, 2023Assignee: ACCESS TO ADVANCED HEALTH INSTITUTEInventors: Christopher B. Fox, Thomas Vedvick, Lucien Barnes V., Ryan M. Kramer, Steven G. Reed
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Publication number: 20230293440Abstract: The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.Type: ApplicationFiled: March 8, 2023Publication date: September 21, 2023Inventors: Christopher B. FOX, Thomas VEDVICK, Lucien BARNES, V, Ryan M. KRAMER, Steven G. REED
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Publication number: 20220280640Abstract: Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.Type: ApplicationFiled: April 28, 2022Publication date: September 8, 2022Inventor: Christopher B. FOX
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Publication number: 20220257754Abstract: Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.Type: ApplicationFiled: April 28, 2022Publication date: August 18, 2022Inventor: Christopher B. FOX
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Patent number: 11344619Abstract: Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.Type: GrantFiled: May 11, 2017Date of Patent: May 31, 2022Assignee: ACCESS TO ADVANCED HEALTH INSTITUTEInventor: Christopher B. Fox
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Publication number: 20220160632Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.Type: ApplicationFiled: December 23, 2021Publication date: May 26, 2022Inventors: Christopher B. Fox, Susan S. Lin, Darrick Carter, Neal Van Hoeven, Mayuresh M. Abhyankar, William A. Petri
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Patent number: 11266602Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.Type: GrantFiled: May 15, 2017Date of Patent: March 8, 2022Assignee: INFECTIOUS DISEASE RESEARCH INSTITUTEInventors: Christopher B. Fox, Susan S. Lin, Darrick Carter, Neal Van Hoeven, Mayuresh M. Abhyankar, William A. Petri
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Publication number: 20220054416Abstract: Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.Type: ApplicationFiled: September 9, 2021Publication date: February 24, 2022Inventors: Christopher B. FOX, Amit Praful KHANDHAR, Neal VAN HOEVEN, Jesse H. ERASMUS, Susan S. LIN
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Publication number: 20220016042Abstract: Provided herein are nanoalum particles comprising an aluminum salt and a sizing agent, wherein the size of the particle ranges from about 1 nm to 450 nm. Such a nanoalum particles are stable and are amenable to a terminal sterilization step prior to vialing. Compositions comprising the nanoalum particles, and the making and using of the nanoalum particles are also provided.Type: ApplicationFiled: August 25, 2021Publication date: January 20, 2022Inventors: Neal VAN HOEVEN, Traci MIKASA, Christopher B. FOX, Anwar AHNIYAZ, Mark T. ORR, Amit KHANDHAR
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Patent number: 11173126Abstract: Provided herein are nanoalum particles comprising an aluminum salt and a sizing agent, wherein the size of the particle ranges from about 1 nm to 450 nm. Such nanoalum particles are stable and are amenable to a terminal sterilization step prior to vialing. Compositions comprising the nanoalum particles, and the making and using of the nanoalum particles are also provided.Type: GrantFiled: May 31, 2017Date of Patent: November 16, 2021Assignee: Infectious Disease Research InstituteInventors: Neal Van Hoeven, Traci Mikasa, Christopher B. Fox, Anwar Ahniyaz, Mark T. Orr, Amit Khandhar
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Patent number: 11141377Abstract: Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.Type: GrantFiled: June 15, 2018Date of Patent: October 12, 2021Assignee: Infectious Disease Research InstituteInventors: Christopher B. Fox, Amit Praful Khandhar, Neal Van Hoeven, Jesse H. Erasmus, Susan S. Lin
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Publication number: 20200276299Abstract: Provided herein are liposomal formulations containing saponin and optionally, a lipopolysaccharide. Also provided IC herein are pharmaceutical compositions and vaccine compositions comprising the liposomal formulations and an antigen. The pharmaceutical compositions and vaccine compositions are capable of eliciting or enhancing of an immune response, for example, for vaccine or therapeutic uses. Compositions and methods related to making the liposomal formulations and using the liposomal formulations for eliciting or enhancing an immune response are also provided.Type: ApplicationFiled: September 7, 2018Publication date: September 3, 2020Inventors: Christopher B. FOX, Susan S. LIN
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Publication number: 20200230056Abstract: Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.Type: ApplicationFiled: June 15, 2018Publication date: July 23, 2020Inventors: Christopher B. FOX, Amit Praful KHANDHAR, Neal VAN HOEVEN, Jesse H. ERASMUS, Susan S. LIN
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Publication number: 20200138715Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.Type: ApplicationFiled: May 15, 2017Publication date: May 7, 2020Applicants: Infectious Disease Research Institute, University of Virginia Patent FoundationInventors: Christopher B. Fox, Susan S. Lin, Darrick Carter, Neal Van Hoeven, Mayuresh M. Abhyankar, William A. Petri
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Publication number: 20200085757Abstract: Provided herein are nanoalum particles comprising an aluminum salt and a sizing agent, wherein the size of the particle N ranges from about 1 nm to 450 nm. Such nanoalum particles are stable and are amenable to a terminal sterilization step prior to vialing. Compositions comprising the nanoalum particles, and the making and using of the nanoalum particles are also provided.Type: ApplicationFiled: May 17, 2017Publication date: March 19, 2020Applicant: Infectious Disease Research InstituteInventors: Neal Van Hoeven, Traci Mikasa, Christopher B. Fox, Anwar Ahniyaz, Mark T. Orr, Amit Khandhar
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Publication number: 20190142935Abstract: Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.Type: ApplicationFiled: May 11, 2017Publication date: May 16, 2019Applicant: Infectious Disease Research InstituteInventor: Christopher B. Fox
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Publication number: 20160324783Abstract: The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.Type: ApplicationFiled: December 29, 2014Publication date: November 10, 2016Applicant: Infectious Disease Research InstituteInventors: Christopher B. FOX, Thomas S. VEDVICK, Lucien BARNES V., Ryan M. KRAMER, Steven G. REED