Abstract: Devices and methods of modifying tissue for low profile and ultra profile rongeur devices to treat spinal tissue. These devices may include a curved or curveable distal region; the cutting member may be configured to operate in the curved region. Also described herein are tissue modification devices that may be flexible or bendable for positioning in the tissue (including the spinal region) but can be made rigid once in position, or otherwise fixed in place to allow leverage when modifying the tissue.

Abstract: Techniques for operating a subcutaneous implant device are disclosed. The implant device can be formed of a non-magnetic material that is compatible with diagnostics such as magnetic resonance imaging (MRI) and can include a rotor element that rotates under the influence of an external magnetic field. The implant device includes a tension relief mechanism for relieving excessive force applied between the implant device and a portion of a patient's tongue. A non-implanted device can include a stator and drive circuitry for generating the external magnetic field. The non-implanted device can receive a user command and can vary the external magnetic field based on the command. When activated by the magnetic field, the implant device can change its operating state to interact with the patient's body.

Abstract: Devices and methods of modifying tissue for low profile and ultra profile rongeur devices to treat spinal tissue. These devices may include a curved or curveable distal region; the cutting member may be configured to operate in the curved region. Also described herein are tissue modification devices that may be flexible or bendable for positioning in the tissue (including the spinal region) but can be made rigid once in position, or otherwise fixed in place to allow leverage when modifying the tissue.

Abstract: An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods and devices for removing, the device are also disclosed. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.

Abstract: The present invention relates to improved methods for the incorporation of DNA into the genome of a Zea mays plant by means of Agrobacterium-mediated transformation. Preferred is the use of the Zea may lines deposited with American Type Culture Collection under the Patent Deposit Designation PTA-6170 and PTA-6171.

Abstract: An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed.

Abstract: Techniques for operating a subcutaneous implant device are disclosed. The implant device can be formed of a non-magnetic material that is compatible with diagnostics such as magnetic resonance imaging (MRI) and can include a rotor element that rotates under the influence of an external magnetic field. The implant device includes a tension relief mechanism for relieving excessive force applied between the implant device and a portion of a patient's tongue. A non-implanted device can include a stator and drive circuitry for generating the external magnetic field. The non-implanted device can receive a user command and can vary the external magnetic field based on the command. When activated by the magnetic field, the implant device can change its operating state to interact with the patient's body.

Abstract: The present invention relates to improved methods for the incorporation of DNA into the genome of a Zea mays plant by means of Agrobacterium-mediated transformation. Preferred is the use of the Zea may lines deposited with American Type Culture Collection under the Patent Deposit Designation PTA-6170 and PTA-6171.

Abstract: A tongue implant control system and methods for stabilizing the tongue are disclosed. The tongue implant control system includes an implant device and a non-implanted control device in wireless communication. The control device provides an inductive power transfer for operating the implant device. The control device also sends commands for changing a state of the implant device. The implant device includes a flexible portion for attachment to the tongue and to one or more actuators. The one or more actuators may include shape memory material. The implant device detects a command from the control device and powers an actuator based on the command. Optionally, the implant device communicates its operating state to the control device and the control device displays information about the implant device at a user interface.

Abstract: An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods and devices for removing, the device are also disclosed. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.

Abstract: An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed.

Abstract: A therapeutic agent capable of of binding to the F′-G′ loop of domain 4 of the common c Chain of the receptor for GM-CSF, IL-3, and IL-5. The amino acid Tyr421 which is located in the F′-G′ loop is critical in the high affinity binding and stimulation of function of GM-CSF, IL-3 and IL-5 to the common c chain of the receptors. Other receptors for cytokines also show hydrophobic amino acids in analogous positions and it is probable that they too play a pivotal role in binding of respective cytokines to them and in modulating function. Agents capable of binding to the F′-G′ loops are suggested and should be of therapeutic value.

Abstract: A therapeutic agent capable of of binding to the F?-G? loop of domain 4 of the common c Chain of the receptor for GM-CSF, IL-3, and IL-5. The amino acid Tyr421 which is located in the F?-G? loop is critical in the high affinity binding and stimulation of function of GM-CSF, IL-3 and IL-5 to the common c chain of the receptors. Other receptors for cytokines also show hydrophobic amino acids in analogous positions and it is probable that they too play a pivotal role in binding of respective cytokines to them and in modulating function. Agents capable of binding to the F?-G? loops are suggested and should be of therapeutic value.