Abstract: A method including rendering a view of a virtual environment of a video game for display in a head mounted display of a user, wherein the virtual environment includes a plurality of objects. The method including tracking gaze of the user. The method including detecting that the gaze of the user is directed towards an object in the view for a period of time. The method including generating a heads up display (HUD) interface including information related to the object. The method including surfacing the HUD interface near the object in the view of the virtual environment.

Abstract: Systems and methods are provided for analyzing one or more root causes of service degradation events in a network or other environment. A method, according to one implementation, includes a step of monitoring a plurality of overlying services offered in an underlying infrastructure having a plurality of resources arranged with a specific topology. In response to detecting a negative impact on the overlying services during a predetermined time window and based on an understanding of the specific topology, the method further includes the step of identifying suspect components from the plurality of resources in the underlying infrastructure. The method also includes the step of obtaining status information with respect to the suspect components to determine a root cause of the negative impact on the overlying services.

Abstract: Methods are provided for recommending actions to improve operability of a network. In one implementation, a method includes acknowledging a plurality of subnetworks in a whole network, each subnetwork including multiple nodes and being represented by a tunnel group having multiple end-to-end tunnels through the subnetwork. The method also includes selecting a first group of subnetworks from the plurality of subnetworks and generating a Reinforcement Learning (RL) agent for each subnetwork of the first group. Each RL agent is based on observations of end-to-end metrics of the end-to-end tunnels of the respective subnetwork. The observations are independent of specific topology information of the subnetwork. Also, the method includes training a global model based on the RL agents of the first group of subnetworks and applying the global model to an Action Recommendation Engine (ARE) configured for recommending actions that can be taken to improve a state of the whole network.

Abstract: Systems and methods are provided for analyzing one or more root causes of service degradation events in a network or other environment. A method, according to one implementation, includes a step of monitoring a plurality of overlying services offered in an underlying infrastructure having a plurality of resources arranged with a specific topology. In response to detecting a negative impact on the overlying services during a predetermined time window and based on an understanding of the specific topology, the method further includes the step of identifying suspect components from the plurality of resources in the underlying infrastructure. The method also includes the step of obtaining status information with respect to the suspect components to determine a root cause of the negative impact on the overlying services.

Abstract: A Laser Imaging Detection and Ranging (LIDAR) system comprises a memory configured to store LIDAR measurement data obtained by the LIDAR system representative of a three-dimensional (3D) space in a field of view of the LIDAR system and signal processing circuitry. The signal processing circuitry is and configured to convert the LIDAR measurement data to a voxel characteristic of voxels of the 3D space, process and adjust a voxel characteristic of a first voxel of the 3D space using a voxel characteristic of other voxels within a specified distance of the first voxel in the 3D space, continue to process and adjust the voxel characteristics of all voxels in the 3D space, and generate an indication of presence of an object in the field of view according to the adjusted voxel characteristics.

Abstract: Methods for purification and extraction of GM1 ganglioside from cells derived from sheep afflicted with GM1 gangliosidosis or from cells derived from human patients with GM1 gangliosidosis as stable and renewable sources of GM1.

Abstract: Methods for purification and extraction of GM1 ganglioside from cells derived from sheep afflicted with GM1 gangliosidosis or from cells derived from human patients with GM1 gangliosidosis as stable and renewable sources of GM1.

Abstract: An in situ desalination apparatus comprising a reverse osmosis unit (15) having a reverse osmosis medium, the reverse osmosis unit in use to be located within a body of water under ambient bio-physico-chemical conditions often different from those at the surface, the unit having an inlet (17) opening to one side of the reverse osmosis medium, in use the inlet to be located below the upper surface of a body of water, the unit having a concentrate outlet (25) opening to the one side of the reverse osmosis medium and opening into the exterior of the unit at a position spaced below the inlet to return concentrate into the water body, the unit having a permeate outlet (27) opening to the other side of the reverse osmosis medium, the permeate outlet communicating with a delivery line extending from the body of water, a pump (23) between body of water and the reverse osmosis unit and adapted to pressurize the water located at the one side of the reverse osmosis medium.

Abstract: Systems and methods are disclosed for providing software performance testing. The results of a test may be determined valid if the test reached a defined test criteria after performing N number of iterations. If the test has not reached the defined test criteria and if N is less than a maximum value, one may be added to N and additional iteration of the test may be performed until the test reaches the defined test criteria or until N reaches the maximum value. If the test reaches the defined test criteria after any additional iteration of the test before N reaches the maximum value, the results of the test may be deemed valid. Moreover, if the test reached the defined test criteria with an outlier removed from the results, the results of the test may be deemed valid. Otherwise, the results of the test may be deemed invalid.

Abstract: An in situ desalination apparatus comprising a reverse osmosis unit (15) having a reverse osmosis medium, the reverse osmosis unit in use to be located within a body of water under ambient bio-physico-chemical conditions often different from those at the surface, the unit having an inlet (17) opening to one side of the reverse osmosis medium, in use the inlet to be located below the upper surface of a body of water, the unit having a concentrate outlet (25) opening to the one side of the reverse osmosis medium and opening into the exterior of the unit at a position spaced below the inlet to return concentrate into the water body, the unit having a permeate outlet (27) opening to the other side of the reverse osmosis medium, the permeate outlet communicating with a delivery line extending from the body of water, a pump (23) between body of water and the reverse osmosis unit and adapted to pressurise the water located at the one side of the reverse osmosis medium.

Abstract: This invention relates to nicotinamide derivatives of general formula (I): in which R1, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Abstract: A process is provided for the preparation of compounds of formula (I) herein comprising reacting a compound of formula (II), (III), (IV) or (V) in the presence of ?OR3 and a hydroxide trapping agent or in the case of compounds of formula (IV) reacting in the presence of an auxiliary base and a hydroxide trapping agent ( i.e. ?OR3 is substituted by the auxiliary base), wherein X is a leaving group and R1 to R4 are as defined.

Abstract: The present invention provides a compound of formula (I): where Q is a group of formula: These compounds inhibit cyclic guanosine 3?,5?-monophosphate phosphodiesterases (cGMP PDEs). More notably, the compounds are potent and selective inhibitors of the type 5 cyclic guanosine 3?,5?-monophosphate phosphodiesterases and have utility therefore in a variety of therapeutic areas. In particular, the present compounds are of value for the curative or prophylactic treatment of mammalian sexual disorders.

Abstract: This invention relates to nicotinamide derivatives of general formula (I): in which R1, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Abstract: This invention relates to nicotinamide derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing, and the uses of such derivatives: wherein R1 is selected from the group consisting of hydrogen, methyl or halo; R7 is attached to the 3- or 4-position of the phenyl ring and is S(O)pR8, R8 is (C1-C4)alkyl optionally substituted by (C3-C6)cycloalkyl; p is 0, 1 or 2; R6 is selected from the group consisting of hydrogen, halo, (C1-C3)alkyl and (C1-C3)alkoxy; m is 0 or 1; L is a (C3-C8)carbocyclic non-aromatic ring; R2 is hydrogen, hydroxy, (C1-C3)alkoxy, (C1-C3)alkyl (optionally substituted by hydroxy or by (C1-C3)alkoxy), CO2R9, NR10R11 or CONR10R11; R3 is hydrogen or (C1-C3)alkyl; R9 is hydrogen or (C1-C3)alkyl; R10 and R11 are each independently hydrogen, or, are selected from the group consisting of: (C1-C6)alkyl optionally substituted by phenyl or a 5- or 6-membered heterocyclic ring incorporating 1 to 3 het

Abstract: This invention relates to nicotinamide derivatives of general formula (I): in which X, Y, n, Z, L and R have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Abstract: This invention relates to nicotinamide derivatives of general formula (I): in which R1, Z and R2 have the meanings defined herein, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of such derivatives.

Abstract: Environmental monitoring of low concentration of organic compounds in a medium such as ground water or another environmental fluid is effected by using a diffusion cell (112) having a polymeric membrane formed into a helical tube (125) and immersed in the environmental fluid so that organic compounds at ppb and ppt concentrations diffuse into and through the polymeric material. A carrier gas in the polymeric tube acquires a concentration of the organic compounds substantially in equilibrium with the concentration of the organic compounds in the environmental fluid. For the purpose of permitting monitoring with detectors (116) which are not sensitive to extremely low levels of organic compounds, a concentrating device such as a thermal desorption tube (114) can be provided for processing the gas and periodic thermal activation to discharge therefrom organic compounds to be detected at a sensor.

Abstract: A Diffusion cell for use in monitoring levels of gases or volatile organic compounds within bulk media such as ground water, effluent, or air. The diffusion cell is of sealed hollow construction and has a membrane providing an interface between a gas phase contained within the diffusion cell and the bulk media. The membrane is permeable to gas and volatile organic compounds while being relatively impermeable to water (i.e. hydrophobic). The diffusion cell includes a core of porous material to minimize the internal volume within. In use, a sensor is located in close proximity to the core of porous material to minimize the dead volume between the sensor and the diffusion cell. The minimization of the internal and dead volumes allows for decreased response times to fluctuations in levels being measured, lending the diffusion cell to real time monitoring applications.