Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.

Abstract: Exemplary methods, apparatuses, and systems receive, from a first user of a network service, an identifier associated with an account within the network service for a second user and data that is descriptive of the second user. Based upon the descriptive data, a plurality of candidate songs is selected and presented to the first user. A selection of a plurality of the candidate songs is received from the first user. A media object including the selected songs as a musical compilation is generated and published to the network service. In response to receiving an interaction with the media object, the network service plays the musical compilation.

Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.

Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.

Abstract: Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects without MS, distinguish progressive MS patients from patients with relapsing-remitting MS, identify subjects with non-MS inflammatory neurological diseases, differentiate healthy subjects from patients with any type of neurological disease, and/or identify subjects with increased disability, CNS tissue damage and/or neurodegeneration. Process-specific biomarkers that can be used in place of a brain biopsy to identify immune cell infiltration and/or activation in the CNS are also described.

Abstract: Exemplary methods, apparatuses, and systems receive, from a first user of a network service, an identifier associated with an account within the network service for a second user and data that is descriptive of the second user. Based upon the descriptive data, a plurality of candidate songs is selected and presented to the first user. A selection of a plurality of the candidate songs is received from the first user. A media object including the selected songs as a musical compilation is generated and published to the network service. In response to receiving an interaction with the media object, the network service plays the musical compilation.

Abstract: A method for bundling event memories in a social networking system. The method includes identifying a first plurality of user-submitted content items posted to the social networking system that are related to an event involving a plurality of users. The social networking system aggregates the first plurality of user-submitted content items into a bundled event memory, and transmits the bundled event memory to at least some of a plurality of user devices to be presented to at least some of the plurality of users, wherein the plurality of users utilize the plurality of user devices to communicate with the social networking system.

Abstract: A method in a social networking system enables social competition between its users. The method includes receiving, from a user device of a user, a challenge creation request message, which includes a challenge indication describing a competition that a set of users may participate in, a challenge stakes indication describing at least one of an award for a winner of the competition and a consequence for losers of the competition, and a set of user identifiers for the set of users. The social networking system notifies the set of users about the competition, receives challenge acceptance messages from some of the users, receives a challenge completion message indicating the winner of the competition, and receives evidence indicating a fulfillment of the challenge stakes. The social networking system transmits information about the competition to a set of one or more user devices of a second set of users.