Abstract: Provided herein are devices for concentrating biological fluids such as serum or plasma, methods of using biological fluid concentrators, and methods of treatment of soft tissue damage and injuries.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: Systems and methods for preparing enriched biological samples, and methods of use thereof are described herein. The systems can include a containment device connected to a first insert to collect tissue fragments in the containment device or to a second insert to incubate tissue fragments with a blood sample in the containment device. The methods can include methods for preparing a cytokine or growth factor-enriched biological sample, such as IL-1 Ra-enriched serum, methods of treating inflammation, inflammatory joint, or rheumatoid arthritis, and methods of preventing inflammation of a joint following arthroscopic surgery.

Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: Provided herein are systems and methods for biological sample concentration, purification, and fractionation of biological samples. The systems can comprise one or more containment devices for a biological sample connected to a shaft; a handheld motor source connected to the shaft and configured to modulate spinning the one or more containment devices along an axis of the one or more containment devices.

Abstract: Embodiments provide methods of collecting stem cells. The methods can comprise connecting the proximal opening of the in-line cage device to a second device for liberating cells from a tissue in a fluid; connecting the distal opening of the in-line cage device to a suction or aspiration apparatus; and collecting stem cells on the graft or suture material. The graft can be e.g., demineralized bone matrix (DBM), bone, soft tissue, cartilage, tendon, ligament, muscle, adipose tissue, fascia, a suture, or an artificial scaffold. The second device for liberating cells can be an arthroscopic shaver, an arthroscopic bone cutter, an arthroscopic burr, or an arthroscopic drill. The method can further comprise connecting a filter device to the in-line cage device to remove tissue fragments from the fluid.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: A heat and moisture exchanger device comprising a housing containing a microcurrent-generating filter capable of generating a low level microcurrent. A microcurrent-generating filter can reduce the number of living or active microbes.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.