Abstract: The present disclosure relates to methods and systems for monitoring release pipelines. The methods and systems calculate health metrics of release pipelines using telemetry data from the release pipelines. The methods and systems determine whether the release pipelines are healthy based on the health metrics. The methods and systems automatically trigger one or more actions in response to determining that the release pipelines are unhealthy and continue to monitor the release pipelines in response to determining that the release pipelines are healthy.

Abstract: A triple syringe system that allows for a larger output of autologous conditioned plasma (ACP) is provided. Autologous blood or bone marrow aspirate can be introduced into a nested set of syringes, which are subjected to centrifugation to obtain two or more of blood or bone marrow fractions including a first fraction and a second fraction. The first fraction can be transferred from the first syringe to the second and third syringes to obtain the ACP.

Abstract: Provided herein are devices for concentrating biological fluids such as serum or plasma, methods of using biological fluid concentrators, and methods of treatment of soft tissue damage and injuries.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: Systems and methods for preparing enriched biological samples, and methods of use thereof are described herein. The systems can include a containment device connected to a first insert to collect tissue fragments in the containment device or to a second insert to incubate tissue fragments with a blood sample in the containment device. The methods can include methods for preparing a cytokine or growth factor-enriched biological sample, such as IL-1 Ra-enriched serum, methods of treating inflammation, inflammatory joint, or rheumatoid arthritis, and methods of preventing inflammation of a joint following arthroscopic surgery.

Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: Devices and methods for extracting and concentrating therapeutically active factors from mammalian fluids and tissues are described herein.

Abstract: A triple syringe system that allows for a larger combined output of PRP (platelet rich plasma) and PPP (platelet poor plasma). The multi-syringe system allows for the connection of two or more additional syringes. The fractions may be extracted with the multi-syringe system of the present invention at different sequential times, or at the same time.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.

Abstract: Provided herein are systems and methods for biological sample concentration, purification, and fractionation of biological samples. The systems can comprise one or more containment devices for a biological sample connected to a shaft; a handheld motor source connected to the shaft and configured to modulate spinning the one or more containment devices along an axis of the one or more containment devices.

Abstract: Embodiments provide methods of collecting stem cells. The methods can comprise connecting the proximal opening of the in-line cage device to a second device for liberating cells from a tissue in a fluid; connecting the distal opening of the in-line cage device to a suction or aspiration apparatus; and collecting stem cells on the graft or suture material. The graft can be e.g., demineralized bone matrix (DBM), bone, soft tissue, cartilage, tendon, ligament, muscle, adipose tissue, fascia, a suture, or an artificial scaffold. The second device for liberating cells can be an arthroscopic shaver, an arthroscopic bone cutter, an arthroscopic burr, or an arthroscopic drill. The method can further comprise connecting a filter device to the in-line cage device to remove tissue fragments from the fluid.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: A heat and moisture exchanger device comprising a housing containing a microcurrent-generating filter capable of generating a low level microcurrent. A microcurrent-generating filter can reduce the number of living or active microbes.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

Abstract: Devices and methods for collecting tissue fragments of variable sizes from a surgical site are described herein. The devices can include at least two filters having a different pore size for the collection and sorting of tissue fragments by size.