Abstract: A method for determining a route warranty for one or more vehicle systems includes determining plural different paths for a trip of a first vehicle system from an origin location to a destination location in a transportation network formed from paths interconnected with each other at nodes, determining whether travel by the first vehicle system along the different routes fails one or more tests that restrict how the first vehicle system travels in the transportation network, and determining a route warranty for the first vehicle system based on the one or more tests. The route warranty reserves one or more of the paths for travel by the first vehicle system from the origin location to the destination location such that other vehicle systems are prevented from traveling on the one or more of the paths reserved by the route warranty.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions. The invention also provides the use of a system of the invention for the treatment of a condition associated with tissue ischaemia or a wound and the use of a system of the invention in combination with an anaesthetic for the treatment or prevention of pain.

Abstract: A system and method for determining a route warranty for one or more vehicle systems determine plural different paths for a trip of a first vehicle system from an origin location to a destination location in a transportation network formed from paths interconnected with each other at nodes, determine whether travel by the first vehicle system along the different routes fails one or more tests that restrict how the first vehicle system travels in the transportation network, and determine a route warranty for the first vehicle system based on the one or more tests. The route warranty reserves one or more of the paths for travel by the first vehicle system from the origin location to the destination location such that other vehicle systems are prevented from traveling on the one or more of the paths reserved by the route warranty.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions; wherein the layer containing a nitrite and/or the hydrogel comprises a pharmaceutically active agent. The invention also provides the use of a system of the invention in medicine, and in the treatment of pain.

Abstract: The present invention provides a system comprising: (i) a layer containing a nitrite; and (ii) a hydrogel that contains hydrogen ions. The invention also provides the use of a system of the invention for the treatment of a condition associated with tissue ischaemia or a wound and the use of a system of the invention in combination with an anaesthetic for the treatment or prevention of pain.

Abstract: The present invention is directed to methods and products for defining a biomarker of disease phenotype. The present invention further relates to methods and kits for determining a subject's risk of developing recurrent hepatocellular carcinoma based on a defined microRNA biomarker that reliably distinguishes hepatocellular carcinoma disease recurrence from non-recurrence. The invention also relates to methods of treating a patient having heptocellular carcinoma based on their risk of developing hepatocellular carcinoma disease recurrence.

Abstract: A pressure sensor assembly comprises a sensor housing having a flexible wall that is configured to deform in response to a pressure difference between the interior and exterior of the sensor housing; -a first fiber optical cable section that is bonded to the flexible wall of the sensor housing such that the length of the first fiber optical cable section changes in response to deformation of the wall in response to the said pressure difference; a second fiber optical cable section which is bonded to a thermal reference body, which body is connected to the sensor housing by a strain decoupled connection mechanism, such as a tack weld or flexible glue, and is configured to deform substantially solely in response to thermal deformation, such that the length of the second fiber optical cable section solely changes in response to thermal deformation of the thermal reference body.

Abstract: An exemplary device includes a processor, one or more communication interfaces, memory and one or more modules stored in the memory that comprise processor executable instructions to receive data from an implantable device via at least one of the one or more communication interfaces, to interrogate the data for one or more particular types of data, to process one or more particular types of data and to transmit information via at least one of the one or more communication interfaces. Various other exemplary devices, methods, systems, etc., are also disclosed.

Abstract: Apparatus for non-disruptive error recovery in a clustered system, comprises a node instance configuration activity quiescing component for quiescing configuration activity at a first virtual node instance; a node instance creation component for creating a second virtual node instance with I/O access blocked; a configuration transfer component for transferring configuration data from the first to the second virtual node instance; a commit component for committing the changeover from the first to the second virtual node instance; a node instance communications blocking component for blocking inbound communications to a first virtual node instance; a node instance communications unblocking component for unblocking I/O access at the second virtual node instance; a communication control component for monitoring outbound communications from the first virtual node instance and signalling completion of all pending outbound communications; and a node instance deletion component for deleting the first virtual node ins

Abstract: Illustrative embodiments provide a computer implemented method for incremental storage de-allocation during a clean process within a point-in-time copy storage management system. The computer implemented method determines whether to perform the clean process and responsive to a determination to perform the clean process, determines whether a set of discrepant bits is present. Responsive to the determination that the set of discrepant bits is present, the computer implemented method copies each dirty grain for each discrepant bit in the set of discrepant bits to a downstream target to form a set of copied dirty grains and determines whether a particular dirty grain in the set of copied dirty grains has been allocated to a space efficient storage unit. Responsive to a determination that the particular dirty grain was allocated to a space efficient storage unit, the computer implemented method de-allocates the particular grain from an upstream source.

Abstract: A pressure sensor assembly comprises a sensor housing having a flexible wall that is configured to deform in response to a pressure difference between the interior and exterior of the sensor housing; —a first fiber optical cable section that is bonded to the flexible wall of the sensor housing such that the length of the first fiber optical cable section changes in response to deformation of the wall in response to the said pressure difference; a second fiber optical cable section which is bonded to a thermal reference body, which body is connected to the sensor housing by a strain decoupled connection mechanism, such as a tack weld or flexible glue, and is configured to deform substantially solely in response to thermal deformation, such that the length of the second fiber optical cable section solely changes in response to thermal deformation of the thermal reference body.

Abstract: An apparatus, method, and computer program for facilitating disaster recovery of a first computer system, wherein first data residing on a first storage device associated with the first computer system is recoverable from second data residing on a second storage device associated with a second computer system and wherein the second storage device is operable to have an associated state of powered up or powered down. A receiver receives an update operation for updating the second storage device. A processor updates a non-volatile storage means with the update operation, prior to update of the second storage device, wherein the non-volatile storage means is associated with the second computer system.

Abstract: A storage controller includes an interface to host computer apparatus and an interface to a plurality of controlled storage apparatus. The storage controller comprises a host write component operable to send a request to write a data object to a source data image at one of said plurality of controlled storage apparatus; a copy component operable in response to a metadata state to control copying of said data object to a target data image in a delimited sequence of data images in a cascade at said plurality of controlled storage apparatus and a fill-in component operable in response to detection of an offline condition of a disk containing said target data image to control substitution of a fill-in disk in place of said disk containing said target data image.

Abstract: Apparatus for non-disruptive error recovery in a clustered system, comprises a node instance configuration activity quiescing component for quiescing configuration activity at a first virtual node instance; a node instance creation component for creating a second virtual node instance with I/O access blocked; a configuration transfer component for transferring configuration data from the first to the second virtual node instance; a commit component for committing the changeover from the first to the second virtual node instance; a node instance communications blocking component for blocking inbound communications to a first virtual node instance; a node instance communications unblocking component for unblocking I/O access at the second virtual node instance; a communication control component for monitoring outbound communications from the first virtual node instance and signalling completion of all pending outbound communications; and a node instance deletion component for deleting the first virtual node ins

Abstract: Illustrative embodiments provide a computer implemented method for incremental storage de-allocation during a clean process within a point-in-time copy storage management system. The computer implemented method determines whether to perform the clean process and responsive to a determination to perform the clean process, determines whether a set of discrepant bits is present. Responsive to the determination that the set of discrepant bits is present, the computer implemented method copies each dirty grain for each discrepant bit in the set of discrepant bits to a downstream target to form a set of copied dirty grains and determines whether a particular dirty grain in the set of copied dirty grains has been allocated to a space efficient storage unit. Responsive to a determination that the particular dirty grain was allocated to a space efficient storage unit, the computer implemented method de-allocates the particular grain from an upstream source.

Abstract: A storage controller includes an interface to host computer apparatus and an interface to a plurality of controlled storage apparatus. The storage controller comprises a host write component operable to send a request to write a data object to a source data image at one of said plurality of controlled storage apparatus; a copy component operable in response to a metadata state to control copying of said data object to a target data image in a delimited sequence of data images in a cascade at said plurality of controlled storage apparatus and a fill-in component operable in response to detection of an offline condition of a disk containing said target data image to control substitution of a fill-in disk in place of said disk containing said target data image.

Abstract: A storage controller includes an interface to host computer apparatus and an interface to a plurality of controlled storage apparatus. The storage controller comprises a host write component operable to send a request to write a data object to a source data image at one of said plurality of controlled storage apparatus; a copy component operable in response to a metadata state to control copying of said data object to a target data image in a delimited sequence of data images in a cascade at said plurality of controlled storage apparatus and a fill-in component operable in response to detection of an offline condition of a disk containing said target data image to control substitution of a fill-in disk in place of said disk containing said target data image.

Abstract: Methods and systems for providing advertising content over the Internet through a hierarchical content-specific node structure and pricing advertising delivery over each node independently. Independent delivery and pricing allows an advertiser to pay more for advertisements delivered to a narrowly targeted audience likely to be interested in the goods or services offered by the advertising entity and to pay less for advertisements directed at a more general audience who may or may not have an interest in the goods or services offered. The less content specific the node is, the less targeted the advertisement will be, and therefore, the less valuable the advertisement will be to the advertising entity. Targeted advertising to multiple levels of content specific nodes is enabled.

Abstract: An elongate tubular heat transfer element having a longitudinal tube axis that runs through the hollow interior of the heat transfer element. The heat transfer element includes a wall of monolithic construction having an outer surface and an inner surface. The wall is formed from a composite material including a matrix and rovings embedded in the matrix. The composite material is in contact with the hollow interior such that the inner surface determines a boundary of the hollow interior which extends longitudinally along the axis of the heat transfer element. The matrix is of a fluoropolymer having embedded therein rovings of boron-free chemically resistant glass fibres. The rovings include from about 20% to about 60% by volume based upon the volume of the composite material, rovings that extend longitudinally in a lengthwise direction parallel to the axis of the heat transfer element and rovings that extend spirally around the axis.

Abstract: It is known to supply solution to a process and to collect effluent therefrom using `bag-in-box` arrangement each having a predetermined volume. However, if the process must be supplied with greater volumes of solution, the use of larger `bag-in-box` arrangements is limited by weight restrictions that an operator can handle. Described herein is a method of using a number of `bag-in-box` arrangements coupled together to provide a larger volume of replenisher solution to a process and to collect of effluent therefrom than would be the case if only a single `bag-in-box` arrangement is used. An automatic changeover system can be utilised which allows the process to be supplied with a greater volume of solution than that which corresponds to the legal weight limit without having to empty the supply `bag-in-box` arrangements into a large replenisher tank.