Patents by Inventor Christopher Bartolome

Christopher Bartolome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADENO-ASSOCIATED VIRUS (AAV) SYSTEMS FOR TREATMENT OF GENETIC HEARING LOSS
    Publication number: 20250236887
    Abstract: Described herein are optimally-modified GJB2 cDNA and associated genetic elements for use in recombinant adeno-associated virus (rAAV)-based gene therapy for the treatment of genetic hearing loss.
    Type: Application
    Filed: January 17, 2025
    Publication date: July 24, 2025
    Inventors: Christopher Bartolome, Luis David Jaramillo, Adrian M. Timmers, Steven Pennock, Mark Shearman
  • Adeno-associated virus (AAV) systems for treatment of genetic hearing loss
    Patent number: 12241077
    Abstract: Described herein are codon optimized nucleic acid sequences encoding gap junction protein beta 2 (GJB2), and associated genetic elements, for use in recombinant adeno-associated virus (rAAV)-based gene therapy. The rAAV vectors through which GJB2 is packaged can be used for targeted delivery to patients suffering from genetic hearing loss, including patients with autosomal mutations, recessive or dominant, in the GJB2 gene.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: March 4, 2025
    Assignee: Eli Lilly and Company
    Inventors: Christopher Bartolome, Luis David Jaramillo, Adrian M. Timmers, Steven Pennock, Mark Shearman
  • VARIANT ADENO-ASSOCIATED VIRUS (AAV) CAPSID POLYPEPTIDES AND GENE THERAPEUTICS THEREOF FOR TREATMENT OF HEARING LOSS
    Publication number: 20240226330
    Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.
    Type: Application
    Filed: May 5, 2023
    Publication date: July 11, 2024
    Inventors: Steven Pennock, Adrian M. Timmers, Mark Shearman, Christopher Bartolome, Wang Xiaobo, Prahav Dinesh Mathur, Phillip M. Uribe, Stephanie Szobota, Bonnie E. Jacques, Alan C. Foster, Fabrice Piu
  • VARIANT ADENO-ASSOCIATED VIRUS (AAV) CAPSID POLYPEPTIDES AND GENE THERAPEUTICS THEREOF FOR TREATMENT OF HEARING LOSS
    Publication number: 20240131189
    Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.
    Type: Application
    Filed: May 4, 2023
    Publication date: April 25, 2024
    Inventors: Steven Pennock, Adrian M. Timmers, Mark Shearman, Christopher Bartolome, Wang Xiaobo, Prahav Dinesh Mathur, Phillip M. Uribe, Stephanie Szobota, Bonnie E. Jacques, Alan C. Foster, Fabrice Piu