Abstract: The present disclosure provides an example method for validating a trajectory generated by an autonomous vehicle control system (AV trajectory) in a driving scenario. The example method includes (a) obtaining the AV trajectory and a reference trajectory, wherein the reference trajectory describes a desired motion of a vehicle in the driving scenario; (b) determining a plurality of component divergence values for a plurality of divergence metrics, wherein a respective divergence value characterizes a respective difference between the AV trajectory and the reference trajectory; (c) providing the plurality of component divergence values to a machine-learned model to generate a score that indicates an aggregate divergence between the AV trajectory and the reference trajectory, wherein the machine-learned model comprises a plurality of learned parameters defining an influence of the plurality of component divergence values on the score; and (d) validating the AV trajectory based on the score.

Abstract: The present invention relates to an apparatus for fastening a functional element to a section of a workpiece and/or for reshaping a section of the workpiece, comprising a support device for supporting the workpiece, wherein the workpiece section has a first surface facing the support device and a second surface facing away from the support device. The support device comprises a first support element having a first workpiece support surface that is associated with the first surface, and a second support element having a second workpiece support surface that faces away from the first workpiece support surface and that is associated with a supporting surface. The first and the second support element are movable relative to one another by a spreading device such that the first and the second workpiece support surface can be moved away from one another in an axial direction, in particular wherein the axial direction extends perpendicular to the first and/or second workpiece support surface.

Abstract: The present invention relates to an apparatus for fastening a functional element to a section of a workpiece and/or for reshaping a section of the workpiece, said apparatus comprising a support device for supporting the workpiece, wherein the workpiece section has a first surface facing the support device and a second surface facing away from the support device. The support device comprises a first support element having a first workpiece support surface that is associated with the first surface, and a second support element having a second workpiece support surface that faces away from the first workpiece support surface and that is associated with a supporting surface. The first and the second support element are movable relative to one another by means of a spreading device such that the first and the second workpiece support surface can be moved away from one another in an axial direction, in particular wherein the axial direction extends perpendicular to the first and/or second workpiece support surface.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein X1, R1, R2, R3, R4, R5, R6, R6?, R7, R7?, R8, R9, R9?, R10, R11, R12, and n are described herein.

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Abstract: In various representative aspects, a cleaning system for paint rollers that also recaptures a paint that is removed from the paint roller during cleaning. The system includes a platform that securely attaches to the top rim of an open paint can and provides a base for vertically fixing a standard paint roller on top of the base so that excess paint can be removed from the roller and recaptured back in the well of the paint can. The exemplary embodiments in this invention offers an improvement over existing systems and methods for 1) cleaning paint rollers and recapturing unused paint from the rollers more efficiently than existing products as well as 2) using the same system to rinse any residual paint from the roller so that the roller can be used again.

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Abstract: Methods and systems are described to automatically identify, measure, and resolve the problem of confounding audiences for predictive modeling exercises involving classification. An example system is described for recursively executing an algorithm that ingests, at minimum, one or more predictors, an outcome variable, a performance improvement threshold at which the system will terminate, and a maximum recursion depth at which the system will terminate if the performance improvement threshold is not met.

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Abstract: Methods and apparatuses for the analysis of mass spectroscopic (MS) data as well as ultraviolet (UV) absorption data. In particular, described herein are tools and methods to assist in generating annotated peptide maps from a raw MS data.

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

Abstract: Object merging in an electronic document may be provided. First, a selection of at least two objects within the electronic document may be received. Then, in response to the received selection of the at least two objects, a menu listing a plurality of merge operations configured to be performed on the selected at least two objects may be provided. A merge operation may then be selected, previewed, and applied to the selected at least two objects.

Abstract: The invention relates to a method of attaching a functional element to a sheet metal part. The functional element has a head part having a ring-shaped support surface and a tubular rivet section that is designed as self-piercing and that extends at the side of the support surface of the head part and away from said head part.

Abstract: A control method is disclosed for determining a quality indicator of medical technology recording results data from a tomography scan of an examination structure, which scan is supported by a contrast agent, by way of a tomography system. According to an embodiment of the invention, at least one control parameter value is automatically derived from the recording results data in respect of a contrast agent image region during and/or directly after the tomography scan, which value represents a quality of the recording results data in the contrast agent image region. A control system for such a determination is also disclosed.

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

Abstract: A longitudinal adjuster in the interior of a motor vehicle, has an upper and a lower rail, between which at least one rolling body is provided. A projection is provided on the upper and/or lower rail, the projection forming a local contact point between the two rails.

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

Abstract: A multi-media device interface (18) couples a multi-media device (16) to a portable electronic device (10). Multi-media and other information can be loaded into the portable electronic device (10) from the multi-media device (16) or stored in the multi-media device (16) from the portable electronic device (10). The multi-media device interface (18) queues commands to the multi-media device (16) from the portable electronic device (10) while the multi-media device (16) completes a previously-issued command.

Abstract: A multi-media device interface (18) couples a multi-media device (16) to a portable electronic device (10). Multi-media and other information can be loaded into the portable electronic device (10) from the multi-media device (16) or stored in the multi-media device (16) from the portable electronic device (10). The multi-media device interface (18) queues commands to the multi-media device (16) from the portable electronic device (10) while the multi-media device (16) completes a previously-issued command.

Abstract: Methods and apparatuses for the analysis of mass spectroscopic (MS) data as well as ultraviolet (UV) absorption data. In particular, described herein are tools and methods to assist in generating annotated peptide maps from a raw MS data.