Abstract: The present disclosure provides an example method for validating a trajectory generated by an autonomous vehicle control system (AV trajectory) in a driving scenario. The example method includes (a) obtaining the AV trajectory and a reference trajectory, wherein the reference trajectory describes a desired motion of a vehicle in the driving scenario; (b) determining a plurality of component divergence values for a plurality of divergence metrics, wherein a respective divergence value characterizes a respective difference between the AV trajectory and the reference trajectory; (c) providing the plurality of component divergence values to a machine-learned model to generate a score that indicates an aggregate divergence between the AV trajectory and the reference trajectory, wherein the machine-learned model comprises a plurality of learned parameters defining an influence of the plurality of component divergence values on the score; and (d) validating the AV trajectory based on the score.

Abstract: The disclosure relates to inhibitors of PCSK9 useful in the treatment of cholesterol lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof, wherein X1, R1, R2, R3, R4, R5, R6, R6?, R7, R7?, R8, R9, R9?, R10, R11, R12, and n are described herein.

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Abstract: In various representative aspects, a cleaning system for paint rollers that also recaptures a paint that is removed from the paint roller during cleaning. The system includes a platform that securely attaches to the top rim of an open paint can and provides a base for vertically fixing a standard paint roller on top of the base so that excess paint can be removed from the roller and recaptured back in the well of the paint can. The exemplary embodiments in this invention offers an improvement over existing systems and methods for 1) cleaning paint rollers and recapturing unused paint from the rollers more efficiently than existing products as well as 2) using the same system to rinse any residual paint from the roller so that the roller can be used again.

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Abstract: Methods and systems are described to automatically identify, measure, and resolve the problem of confounding audiences for predictive modeling exercises involving classification. An example system is described for recursively executing an algorithm that ingests, at minimum, one or more predictors, an outcome variable, a performance improvement threshold at which the system will terminate, and a maximum recursion depth at which the system will terminate if the performance improvement threshold is not met.

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

Abstract: Methods and apparatuses for the analysis of mass spectroscopic (MS) data as well as ultraviolet (UV) absorption data. In particular, described herein are tools and methods to assist in generating annotated peptide maps from a raw MS data.

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

Abstract: Object merging in an electronic document may be provided. First, a selection of at least two objects within the electronic document may be received. Then, in response to the received selection of the at least two objects, a menu listing a plurality of merge operations configured to be performed on the selected at least two objects may be provided. A merge operation may then be selected, previewed, and applied to the selected at least two objects.

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

Abstract: A multi-media device interface (18) couples a multi-media device (16) to a portable electronic device (10). Multi-media and other information can be loaded into the portable electronic device (10) from the multi-media device (16) or stored in the multi-media device (16) from the portable electronic device (10). The multi-media device interface (18) queues commands to the multi-media device (16) from the portable electronic device (10) while the multi-media device (16) completes a previously-issued command.

Abstract: A multi-media device interface (18) couples a multi-media device (16) to a portable electronic device (10). Multi-media and other information can be loaded into the portable electronic device (10) from the multi-media device (16) or stored in the multi-media device (16) from the portable electronic device (10). The multi-media device interface (18) queues commands to the multi-media device (16) from the portable electronic device (10) while the multi-media device (16) completes a previously-issued command.

Abstract: Methods and apparatuses for the analysis of mass spectroscopic (MS) data as well as ultraviolet (UV) absorption data. In particular, described herein are tools and methods to assist in generating annotated peptide maps from a raw MS data.

Abstract: Biomarkers useful for identifying treatments for and monitoring treatment of patients with multiple sclerosis (MS) are provided, as well as methods for their identification, methods of diagnosing MS, relapse of MS patients and disease progression in MS patients.

Abstract: Object merging in an electronic document may be provided. First, a selection of at least two objects within the electronic document may be received. Then, in response to the received selection of the at least two objects, a menu listing a plurality of merge operations configured to be performed on the selected at least two objects may be provided. A merge operation may then be selected, previewed, and applied to the selected at least two objects.

Abstract: Object merging in an electronic document may be provided. First, a selection of at least two objects within the electronic document may be received. Then, in response to the received selection of the at least two objects, a menu listing a plurality of merge operations configured to be performed on the selected at least two objects may be provided. A merge operation may then be selected, previewed, and applied to the selected at least two objects.

Abstract: Object merging in an electronic document may be provided. First, a selection of at least two objects within the electronic document may be received. Then, in response to the received selection of the at least two objects, a menu listing a plurality of merge operations configured to be performed on the selected at least two objects may be provided. A merge operation may then be selected, previewed, and applied to the selected at least two objects.

Abstract: Color selection may be provided. First, a selection of a target object may be received and a color selection mode may be entered. Then a color preview may be provided in response to entering the color selection mode. Next, a color selection may be received in response to providing the color preview. A color of a property of the selected target object may then be set to the received color selection.