Abstract: In various embodiments, methods and systems for managing wake-enabled transport connections of wake-enabled applications is provided. A set of ports is designated as a wake-enabled port set. An operating system (OS) of a computing device running applications plumbs the multiport wake pattern to the one or more network interface controllers (NIC) of the computing device. A wake-enabled application acquires a port from the wake-enabled port set. The OS makes a determination that the application is wake-enabled and as such, assigns a port, from the wake-enable port set, to the wake-enabled application. Upon receiving a packet at the NIC, a determination is made whether the packet corresponds to a wake-enabled transport connection based on comparing the packet to the multiport wake pattern. Upon matching the packet to the multiport wake pattern, the NIC communicates with the OS to wake a portion of the wake-enabled application associated with the wake-enabled transport connection.