Abstract: Disclosed are compounds and compositions that bind to the La-related protein 1 (LARP1). LARP1 has roles as both a repressor of translation and stabilizer of mRNA transcripts, and therefore functions as a molecular switch in cancer biology. LARP1 also upregulates the proliferation of RNA viruses. Accordingly, the compounds and compositions disclosed herein that bind to LARP1 may be used for treating or preventing cancer or viral infections in a subject.

Abstract: A blast attenuating seat system for protecting a vehicle occupant from impulses generated by blasts from underneath the vehicle, and methods for manufacturing and using same. The blast attenuating seat system includes a post, a mounting body coupled to a portion of the post and a seat assembly movably coupled to the mounting body configured to move relative to the post and mounting body. The seat assembly includes a seat body having a seat support structure configured to support a plurality of seat cushions and a shock assembly coupling the seat body and mounting body and configured to compress and expand such that the seat assembly moves relative to the post and mounting body. The blast attenuating seat system thereby provides/enables improved protection for vehicle occupants that may be exposed to explosive blasts.

Abstract: The present invention is directed to new and improved armor protection that can replace the existing crew cabin with a field replaceable armored crew compartment to be attached to the existing body of an HMMWV military vehicle to protect the military personnel within from explosive blasts, roll-over or collisions. In accordance with the concepts of the present invention, in order to provide additional protection to personnel in the HMMWV crew compartment, a sacrificial V-shaped hull is designed to be attached onto the underside of the crew compartment over the HMMWV frame rails. In the event of an explosion underneath the HMMWV, the V-shaped hull will shield the personnel inside the cabin and absorb the force of the explosion.

Abstract: The present invention is directed to new and improved armor protection that can replace the existing crew cabin with a field replaceable armored crew compartment to be attached to the existing body of an HMMWV military vehicle to protect the military personnel within from explosive blasts, roll-over or collisions. In accordance with the concepts of the present invention, in order to provide additional protection to personnel in the HMMWV crew compartment, a sacrificial V-shaped hull is designed to be attached onto the underside of the crew compartment over the HMMWV frame rails. In the event of an explosion underneath the HMMWV, the V-shaped hull will shield the personnel inside the cabin and absorb the force of the explosion.

Abstract: A modular safe system that can include a door unit and a pair of modular cap extension units that can be coupled on opposing sides of the door unit. The modular safe system can further include a corner-extension unit and a straight extension unit.

Abstract: A blast attenuating seat system for protecting a vehicle occupant from impulses generated by blasts from underneath the vehicle, and methods for manufacturing and using same. The blast attenuating seat system includes a post, a mounting body coupled to a portion of the post and a seat assembly movably coupled to the mounting body configured to move relative to the post and mounting body. The seat assembly includes a seat body having a seat support structure configured to support a plurality of seat cushions and a shock assembly coupling the seat body and mounting body and configured to compress and expand such that the seat assembly moves relative to the post and mounting body. The blast attenuating seat system thereby provides/enables improved protection for vehicle occupants that may be exposed to explosive blasts.

Abstract: A modular turret extension system for providing improved situational awareness and methods for manufacturing and using same is provide herein. The turret extension system includes a first and second coupling end, a plurality of extension members extending between the first and second coupling end, a viewing chamber defined by the first and second coupling ends and the plurality of extension members and a plurality of viewing ports each defined by a portion of one or more of the extension members.

Abstract: A modular turret extension system for providing improved situational awareness and methods for manufacturing and using same is provide herein. The turret extension system includes a first and second coupling end, a plurality of extension members extending between the first and second coupling end, a viewing chamber defined by the first and second coupling ends and the plurality of extension members and a plurality of viewing ports each defined by a portion of one or more of the extension members.

Abstract: A blast attenuating seat system for protecting a vehicle occupant from impulses generated by blasts from underneath the vehicle, and methods for manufacturing and using same. The blast attenuating seat system includes a post, a mounting body coupled to a portion of the post and a seat assembly movably coupled to the mounting body configured to move relative to the post and mounting body. The seat assembly includes a seat body having a seat support structure configured to support a plurality of seat cushions and a shock assembly coupling the seat body and mounting body and configured to compress and expand such that the seat assembly moves relative to the post and mounting body. The blast attenuating seat system thereby provides/enables improved protection for vehicle occupants that may be exposed to explosive blasts.

Abstract: A modular safe system that can include a door unit and a pair of modular cap extension units that can be coupled on opposing sides of the door unit. The modular safe system can further include a corner-extension unit and a straight extension unit.

Abstract: The present invention is directed to new and improved armor protection that can replace the existing crew cabin with a field replaceable armored crew compartment to be attached to the existing body of an HMMWV military vehicle to protect the military personnel within from explosive blasts, roll-over or collisions. In accordance with the concepts of the present invention, in order to provide additional protection to personnel in the HMMWV crew compartment, a sacrificial V-shaped hull is designed to be attached onto the underside of the crew compartment over the HMMWV frame rails. In the event of an explosion underneath the HMMWV, the V-shaped hull will shield the personnel inside the cabin and absorb the force of the explosion.

Abstract: A blast attenuating seat system for protecting a vehicle occupant from impulses generated by blasts from underneath the vehicle, and methods for manufacturing and using same. The blast attenuating seat system includes a post, a mounting body coupled to a portion of the post and a seat assembly movably coupled to the mounting body configured to move relative to the post and mounting body. The seat assembly includes a seat body having a seat support structure configured to support a plurality of seat cushions and a shock assembly coupling the seat body and mounting body and configured to compress and expand such that the seat assembly moves relative to the post and mounting body. The blast attenuating seat system thereby provides/enables improved protection for vehicle occupants that may be exposed to explosive blasts.

Abstract: A protective turret is shown and described. In some embodiments the protective turret can include a turret base with a plurality of turret panels that are each rotatably coupled proximate to a portion of an edge of the turret base, the turret panels operable to assume an erected configuration with each of the turret panels extending away from the turret base and defining a turret compartment defined by a portion of the turret base and a portion of the plurality of turret panels, and the turret panels further operable to assume a collapsed configuration by each of the turret panels folding inward within the turret compartment toward the turret base.

Abstract: A modular turret extension system for providing improved situational awareness and methods for manufacturing and using same is provide herein. The turret extension system includes a first and second coupling end, a plurality of extension members extending between the first and second coupling end, a viewing chamber defined by the first and second coupling ends and the plurality of extension members and a plurality of viewing ports each defined by a portion of one or more of the extension members.

Abstract: The present invention is directed to new and improved armor protection that can replace the existing crew cabin with a field replaceable armored crew compartment to be attached to the existing body of an HMMWV military vehicle to protect the military personnel within from explosive blasts, roll-over or collisions. In accordance with the concepts of the present invention, in order to provide additional protection to personnel in the HMMWV crew compartment, a sacrificial V shaped hull is designed to be attached onto the underside of the crew compartment over the HMMWV frame rails. In the event of an explosion underneath the HMMWV, the V shaped hull will shield the personnel inside the cabin.

Abstract: The present invention is directed to new and improved armor protection that can replace the existing crew cabin with a field replaceable armored crew compartment to be attached to the existing body of an HMMWV military vehicle to protect the military personnel within from explosive blasts, roll-over or collisions. In accordance with the concepts of the present invention, in order to provide additional protection to personnel in the HMMWV crew compartment, a sacrificial V shaped hull is designed to be attached onto the underside of the crew compartment over the HMMWV frame rails. In the event of an explosion underneath the HMMWV, the V shaped hull will shield the personnel inside the cabin.