Abstract: The invention relates to a method for sequencing oligonucleotides comprising RNA, wherein two indexing sequences are introduced in RNA oligonucleotides. The invention furthermore relates to uses of such methods and devices used for such methods. Further provided are kits comprising one or more components used in the methods of the invention.

Abstract: The present invention relates to an apheresis device (1) for the extracorporeal removal of C-reactive protein from blood of a patient, wherein the apheresis device is connectable to the blood circulation of the patient. The blood is pumped via a part of the extracorporeal circulation system (2) of the apheresis device (1) according to the invention to a cell separator (7) for separation of the blood into blood plasma and cellular components. Via a first outlet of the cell separator (7), the separated blood plasma is directed by means of a plasma line (8A) to an apheresis column (4) for affinity chromatographic removal of C-reactive protein from the blood plasma. After removal of the C-reactive protein from the blood plasma of the patient, said now treated blood plasma is combined with the cellular components of the blood via a plasma line (8B).

Abstract: The present invention provides a novel method for preparing a sequencing library and studying molecular interactions involving a nucleic acid. In particular, the invention relates to a method for preparing a sequencing library, the method comprising the addition of an agent binding to chromatin to a sample comprising a nucleic acid; isolating chromatin bound by said agent; addition of transposase to the isolated chromatin; isolating nucleic acid from chromatin; and obtaining a sequencing library. Moreover, the present invention relates to a method for mapping of molecular interactions involving a nucleic acid, the method comprising the addition of an agent binding to chromatin to a sample comprising a nucleic acid; isolating chromatin bound by said agent; addition of transposase to the isolated chromatin; isolating nucleic acid from chromatin; amplification of nucleic acid; sequencing of amplified nucleic acid; and identifying molecular interactions.

Abstract: The present invention provides a novel method for preparing a sequencing library and studying molecular interactions involving a nucleic acid. In particular, the invention relates to a method for preparing a sequencing library, the method comprising the addition of an agent binding to chromatin to a sample comprising a nucleic acid; isolating chromatin bound by said agent; addition of transposase to the isolated chromatin; isolating nucleic acid from chromatin; and obtaining a sequencing library. Moreover, the present invention relates to a method for mapping of molecular interactions involving a nucleic acid, the method comprising the addition of an agent binding to chromatin to a sample comprising a nucleic acid; isolating chromatin bound by said agent; addition of transposase to the isolated chromatin; isolating nucleic acid from chromatin; amplification of nucleic acid; sequencing of amplified nucleic acid; and identifying molecular interactions.

Abstract: An adjustable carrier for a sterilisation system having a platform configured to provide support for products to be sterilised. The adjustable carrier includes an adjustment mechanism configured to adjust a length of the platform in an intended direction of travel of the carrier.

Abstract: The present invention generally relates set of reference data or “scorecard” for a pluripotent stem cell, and methods, systems and kits to generate a scorecard for predicting the functionality and suitability of a pluripotent stem cell line for a desired use. In some aspects, a method for generating a scorecard comprises using at least 2 stem cell assays selected from: epigenetic profiling, differentiation assay and gene expression assay to predict the functionality and suitability of a pluripotent stem cell line for a desired use.

Abstract: This invention relates to an administration device (1) for administering and modifying operating functions of exchanges (6a . . . 6n) in a telephone network. The operating functions are administered and modified by means of administration commands. Said device comprises co-ordination means (2) for co-ordinating operating functions concerning several exchanges (6a . . . 6n). The invention also relates to a method for administering and modifying operating functions of exchanges (6a . . . 6n), used in this administration device (1).

Abstract: An inflatable aircraft evacuation slide system includes a primary valve, a bust disk and a valve leakage trap operatively disposed between the primary valve and the burst disk. The valve leakage trap comprises a small exhaust vent opening into a flow restriction orifice in the gas path between the primary valve and the burst disk. In operation, when the aircraft emergency exit is opened in the armed condition, the primary valve opens and pressurizes the chamber until the burst disk ruptures allowing inflation gases to pass through the flow restriction orifice to inflate the inflatable evacuation slide. Because there is a substantial pressure drop across the flow restriction orifice, the presence of the valve leakage safety vent in the orifice does not result in significant loss of inflation gas needed for inflating the inflatable evacuation slide. In the event of leakage past the primary valve, however, the valve leakage trap safely vents the leakage pressure to the atmosphere.

Abstract: This invention relates to an administration device (1) for administering and modifying operating functions of exchanges (6a . . . 6n) in a telephone network. The operating functions are administered and modified by means of administration commands. Said device comprises co-ordination means (2) for co-ordinating operating functions concerning several exchanges (6a . . . 6n). The invention also relates to a method for administering and modifying operating functions of exchanges (6a . . . 6n), used in this administration device (1).

Abstract: Data defining electrical waveforms for physical therapy is created on a computer and stored in a removable machine-readable medium such as a CD-ROM or semiconductor memory module. The data is played back, for example on a portable CD-ROM player, to produce the physical therapy waveforms at any time and location convenient or desired by the patient. An interface circuit amplifies and conditions the resulting waveforms for applying them to the skin of the patient via leads and electrodes. Since most therapies use waveforms within the audio frequency range, ubiquitous low-cost audio playback equipment can be used. Advantages of the invention are providing physical therapy at any location and at low cost, without requiring presence of a clinician or other health care professional on location.