Abstract: A computer implemented method of operating a diagnostic instrument such that maintenance processes do not conflict with operator activity is presented. A maintenance process conflicts with operator activity if the probability of use of the diagnostic instrument is above a usage probability threshold. The probability of use of the diagnostic instrument is determined based on detected presence and/or movement of an operator in the proximity of the diagnostic instrument and/or operation of the diagnostic instrument.

Abstract: A computer implemented method of operating a diagnostic instrument such that maintenance processes do not conflict with operator activity is presented. A maintenance process conflicts with operator activity if the probability of use of the diagnostic instrument is above a usage probability threshold. The probability of use of the diagnostic instrument is determined based on detected presence and/or movement of an operator in the proximity of the diagnostic instrument and/or operation of the diagnostic instrument.

Abstract: Nitroxyl is used to inhibit COX-2 activity and particularly to selectively inhibit COX-2 activity. Nitroxyl also is used to treat conditions that respond favorably to inhibition of COX-2 activity in subjects having such conditions. In some cases nitroxyl is used to treat conditions that respond favorably to inhibition of COX-2 activity in subjects having such conditions and who also have at least one other condition for which inhibition of COX-1 activity is disadvantageous. Nitroxyl can be provided directly, but typically is provided with the use of a nitroxyl donor. Nitroxyl donors include any agent or compound (or combination thereof) that donates HNO or NO?. Diazeniumdiolates are used in some cases as nitroxyl donors. In particular instances, diazeniumdiolates having a primary amine group are used as nitroxyl donors. Nitroxyl-donating compounds also are screened for selective COX-2 inhibition for identification as therapeutic agents.