Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: This disclosure describes the use of solanesol as an adjuvant in vaccine compositions, as well as related prophylactic and therapeutic methods. Solanesol may be used to replace squalene in vaccine compositions with similar or superior immunostimulatory effects. Solanesol, which is solid at room temperature, may be formulated for use in vaccine compositions by heating above its melting temperature in an aqueous solution to form a dispersion.

Abstract: An example method of manufacturing a knitted fabric that includes a non-knitted structure occurs in accordance with a programmed knit sequence for a multi-dimensional knitting machine. The method includes, providing a non-knitted structure to the multi-dimensional knitting machine at a point in time when a fabric structure has a first knit portion, wherein the first knit portion is formed based on a first type of knit pattern. The method also includes, after the providing of the non-knitted structure, following the programmed knit sequence to automatically adjust the multi-dimensional knitting machine to use a second type of knit pattern, distinct from a first type of knit pattern, to accommodate the non-knitted structure within a second knit portion that is adjacent to the first knit portion within the fabric structure.

Abstract: An example wearable device that includes a conductive deformable fabric is described herein. The conductive deformable fabric has a conductive trace that has a non-extendable fixed length along a first axis, and the conductive trace is sewn into a fabric structure to produce a conductive deformable material. The fabric structure includes a stitch pattern that facilitates the conductive trace to unfold and fold in an oscillating fashion to allow the conductive trace to expand and contract, respectively, along the first axis without exceeding the fixed length of the conductive trace. The conductive deformable material is positioned within the wearable device such that when the wearable device is worn, the stitch pattern is over a joint of the user to allow the stitch pattern to expand or contract along with the movement of the joint.

Abstract: Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chromatographic method uses reversed-phase (RP) chromatography followed by hydrophilic interaction liquid chromatography (HILIC) to generate substantially pure saponin extracts.

Abstract: A process for coating microporous surfaces which have pores with a size of from 10 to 1500 nm, in which the surfaces in question are coated with at least one coating material curable thermally and with actinic radiation, after which the resulting film(s) is(are) cured thermally and with actinic radiation, wherein the coating material or at least one of the coating materials comprises (a1) at least one constituent containing (a11) on average per molecule at least two functional groups which contain at least one bond which can be activated with actinic radiation and which serves for crosslinking with actinic radiation, and, if desired, (a12) at least one isocyanate-reactive group, (a2) at least one thermally curable constituent containing at least two isocyanate-reactive groups, and (a3) at least one polyisocyanate.

Abstract: The present invention provides a curable coating composition that includes at least three components. The coating composition includes a component (a) having at least one carbamate group or urea group and having a lactone or hydroxy carboxylic acid moiety. The second component (b) of the coating composition is one or more of three materials. First, the second component can be a polymer resin (b)(1) comprising active hydrogen-containing functional groups reactive with the third component(c). Secondly, the second component can be a compound (b)(2) having at least one carbamate group or terminal urea group according to the invention and having at least two linking groups that are urethane or urea. Finally, the second component can be a compound (b)(3) having at least two groups selected from carbamate groups, terminal urea groups, or combinations of the two and at least four urethane or urea linking groups.

Abstract: The present invention provides a curable coating composition that includes at least three components. The coating composition includes a component (a) that includes one or both of a compound (a)(1) having at least one carbamate group or terminal urea group according to the invention and having at least two linking groups that are urethane or urea or a compound (a)(2) having at least two groups selected from carbamate groups, terminal urea groups, or combinations of the two and at least four urethane or urea linking groups. The second component (b) of the coating composition includes a polymer resin comprising active hydrogen-containing functional groups reactive with the third component (c). The resins is selected from polyester, polyurethane, or polyester-polyurethane copolymers Component (c) of the coating composition is a curing agent that is reactive with the first two components. Preparation of coated articles using the compositions of the invention is also disclosed.