Abstract: Disclosed are methods of treating tumors in a subject including but not limited to reducing the size of a primary tumor, preventing progression of a tumor to metastasis. and reducing the extent of metastasis: comprising administering to the subject an attenuated bacteria that expresses an mRNA-mediated virus vaccination antigen in an amount effective to treat the tumor. Further disclosed are methods of preventing infection of cells in a subject by a virus and/or preventing or reducing in the subject symptoms of a disease caused by the virus: comprising administering to the subject an attenuated bacteria that expresses an mRNA-mediated virus vaccination antigen in an amount effective to protect the subject against the virus and/or its effects. Further disclosed are pharmaceutical compositions, cancer immunotherapy compounds. virus vaccines and therapeutic cancer vaccines comprising an attenuated bacteria that expresses an mRNA-mediated virus vaccination antigen, and methods of developing the same.

Abstract: Disclosed are compounds and methods for changing a DNA sequence of an organism comprising delivering to the organism a change agent material which includes a strand invasion agent and a comparison agent. The strand invasion agent is configured to cause a separation of a double-stranded DNA strand in an organism cell. The comparison agent is configured to bind to a first single-stranded organism DNA strand, by including material that presents a number and configuration of hydrogen bonds complementary to the first single-stranded organism DNA strand, except, intentionally, at one or more base pair locations. Accordingly, when the comparison agent material binds to the first single-stranded organism DNA strand and at least one mismatched base pair is indicated on the first single-stranded organism DNA strand as a result of the binding, the organism initiates a mismatch repair process.

Abstract: Systems and methods relating to accounts receivables and blockchain technology. Accounts receivables are tokenized by having an investor pay for a portion of the account receivable debt in exchange for a fixed return. In addition to the fixed return, the investor is then provided with a token that details the entities involved in the debt, the fixed return, the portion of the debt paid for, and the date of expected payment for the debt. These details are also recorded in a blockchain data structure that is continuously replicated by blockchain miners.

Abstract: An illuminated emblem assembly with improved homogeneity includes an emblem body comprising emblem edges, a housing comprising a chamber, a light source positioned at a second end of the chamber, and a light guide positioned over a housing aperture, the light guide having a proximal side facing the emblem body and a distal side facing the light source. Light enters the light guide through a housing-side entry surface disposed on the distal side. A first exit surface is defined by a first proximal edge of the proximal side and a first distal edge of the distal side. A second exit surface is defined by a second proximal edge and a second distal edge. The illuminated emblem assembly includes a reflector that directs light exiting a reflector-side transmissive surface of the light guide back through and toward the first exit surface and the second exit surface.

Abstract: Systems and methods for online advertising. A trading platform system for advertising has a trading data processor and an analysis data processor along with a first database for buyer profiles and a second database for generic target user profiles. Based on the buyer profiles and the target user profile, specific buyers are placed on a list of potential buyers for a specific advertising opportunity. An offer for the opportunity is then sequentially made to each of the potential buyers until one of the potential buyers accepts the offer. The buyer who accepts the offer is allowed to show their advertising content. If an accepting buyer does not complete the transaction, the offer is sent to the next potential buyer on the list. On completion of the transaction, the various databases and the buyer profiles are adjusted with the sales data.

Abstract: Localized and global detection and mitigation of network attacks in a distributed platform are provided. The localized detection identifies attacks occurring at individual nodes of the distributed platform based on packet analysis conducted by each individual node. The global detection identifies attacks occurring across the distributed platform based on packet analysis conducted on traffic aggregated from across the distributed platform. Either detection involves inspecting headers of the sampled packets. Each header property is scored based on an amount of deviation from threshold values. The sum of scores identifies the header properties that form an attack signature. Attack protections are implemented against subsequently arriving packets with header properties matching the attack signature.

Abstract: A replication of a physical network is created in the cloud. The replicated network safely validates configuration changes for any hardware network device of the physical network and the physical network end state resulting from the changes without impacting the physical network steady state. The replicated network creates virtual machines on hardware resources provisioned from the cloud. The virtual machines emulate network device functionality and have the same addressing as the network devices. Nested overlay networks reproduce the direct connectivity that exists between different pairs of the network devices on the virtual machines. A first overlay network formed by a first Virtual Extensible Local Area Network (VXLAN) provides direct logical connections between the cloud machines on which the virtual machines execute.

Abstract: Disclosed are systems and methods for whole-genome replacement through a massively multiplexed homologous template repair process.

Abstract: A replication of a physical network is created in the cloud. The replicated network safely validates configuration changes for any hardware network device of the physical network and the physical network end state resulting from the changes without impacting the physical network steady state. The replicated network creates virtual machines on hardware resources provisioned from the cloud. The virtual machines emulate network device functionality and have the same addressing as the network devices. Nested overlay networks reproduce the direct connectivity that exists between different pairs of the network devices on the virtual machines. A first overlay network formed by a first Virtual Extensible Local Area Network (VXLAN) provides direct logical connections between the cloud machines on which the virtual machines execute.

Abstract: A system and method for monitoring information events partitions sets of information and processing steps into one or more workspaces. The workspaces include sharable portable specifications for implementing event monitoring by a plurality of users or computer systems. Workspaces may be bindable computing resources to establish controls between the computing resources and the workspaces.

Abstract: A system and method for monitoring information events partitions sets of information and processing steps into one or more workspaces. The workspaces include sharable portable specifications for implementing event monitoring by a plurality of users or computer systems. Workspaces may be bindable computing resources to establish controls between the computing resources and the workspaces.

Abstract: A system and method for monitoring information events is configurable by user definable rule specifications. The rule specifications can be included in portable sharable rulebooks. The rulebooks are transportable and may be shared between users, workspaces and computer systems. Each rulebook may be implemented on a single computer or aspects of a rulebook may be distributed among a plurality of computers or computer resources.

Abstract: A system and method for receiving information from at least one information source and producing one or more events in accordance with user configurable data structures. The data structures define one or more processes for handling information events, and may be shareable and transportable between different users and/or workspaces. The data structures and processes may be distributed over a plurality of computers and servers.

Abstract: A system for providing diverse broadband service levels to multiple access points within an established network is provided. Specifically, the system comprises a guest device connected to an access point within the established network and configured to initiate a request for broadband service access. A gateway, in communication with the guest device intercepts the request from the guest device and identifies the access point to which the guest device is connected. Upon interception, the gateway replies to the intercepted request with a predetermined IP address. A connection between the guest device and the established network is formed and a portal webpage, associated with the identified location, is transmitted to the guest device. The portal page allows the guest to select service options available to that location within the established network.

Abstract: A holder for golf tees that has a housing with an open interior. The interior has two curved ends and a thin middle section that forms a “dumb bell” shape. A plate that has a matching dumb bell is fitted into the open interior. Two springs are mounted inside of the housing and are attached to the bottom of the housing and to the bottom of the plate. A retainer pin is placed orthogonally across the top opening of the housing. The pin retains the plate in the housing and secures any tees that are installed as well. Tees are placed into the housing by sliding the pointed end under the retainer pin and pushing down on the plate. To dispense a tee, a user pushes down slightly on the pointed end of the top tee, which raises the other end of that it can be pulled from the holder.

Abstract: A protective coating composition for coating interior surfaces of beer, beverage, and food containers, as well as interior and exterior surfaces of can ends, comprises a polymeric binder of emulsion copolymerized ethylenic monomers in the presence of an unsaturated polyester dispersed into water with an aqueous dispersed epoxy-acrylic graft copolymer dispersant. The preferred polymeric binder comprises by weight between 0.1% and 40% unsaturated polyester, between 20% and 80% emulsion copolymerized ethylenic unsaturated monomers, and at least 20% dispersant, where the emulsion copolymerized monomers crosslink with the water dispersed unsaturated polyester.