Abstract: A surroundings illumination device for illuminating the ground in the surroundings of a motor vehicle contains a controller for controlling the illumination of the ground and a projection module which includes a light device having a plurality of illuminants and an array of projection optics, a respective projection optic containing an associated object structure and an associated projection lens. The array of projection optics includes a plurality of sub-arrays which can be separately illuminated with an illuminant of the light device allocated to the respective sub-array, as a result of which, a partial graphic is generated on the ground in the surroundings of the vehicle by projection of the associated object structures of the projection optics of the respective sub-array.

Abstract: A micro-lens based module including at least one nanostructured layer, the nanostructured layer including one or several diffractive domains corresponding to an optical object. The claimed micro-lens based module allows dynamic and/or coloured projections of optical objects with an improved optical quality. The present invention also relates to a projection device and a method of projection of improved coloured and/or dynamic images.

Abstract: A surroundings illumination device for illuminating the ground in the surroundings of a motor vehicle contains a controller for controlling the illumination of the ground and a projection module which includes a light device having a plurality of illuminants and an array of projection optics, a respective projection optic containing an associated object structure and an associated projection lens. The array of projection optics includes a plurality of sub-arrays which can be separately illuminated with an illuminant of the light device allocated to the respective sub-array, as a result of which, a partial graphic is generated on the ground in the surroundings of the vehicle by projection of the associated object structures of the projection optics of the respective sub-array.

Abstract: A motor vehicle includes a surroundings lighting device with a plurality of projection modules for generating a light distribution on the ground in the surroundings of the motor vehicle. The plurality of projection modules includes a first projection module and a second projection module which are designed and arranged such that when operated the first projection module generates a first light distribution on the ground in the surroundings of the motor vehicle and the second projection module generates a second light distribution which overlaps with the first light distribution on the ground in the surroundings of the motor vehicle. The second light distribution covers a smaller surface area on the ground than the first light distribution and has a higher average illuminance on the ground than the first light distribution.

Abstract: A projection system for a vehicle, in particular for an ambient lighting device for generating a plurality of light cones for illuminating the ground in the surroundings of the vehicle, includes at least one light source and a microlens array. The microlens array includes an optical axis, a first portion with at least one first channel and a second portion with at least one second channel. The projection system includes an optical device that is provided downstream of the microlens array and is arranged at least in the area of the first portion, with the distance between the microlens array and the optical device being less than 20 mm.

Abstract: A projection system for a vehicle, in particular for an ambient lighting device for generating a plurality of light cones for illuminating the ground in the surroundings of the vehicle, includes at least one light source and a microlens array. The microlens array includes an optical axis, a first portion with at least one first channel and a second portion with at least one second channel. The projection system includes an optical device that is provided downstream of the microlens array and is arranged at least in the area of the first portion, with the distance between the microlens array and the optical device being less than 20 mm.

Abstract: The present invention relates to an endothelin receptor antagonist conjugate of the formula (I) wherein R2 is an alkoxy group and one of R1 and R3 represents an alkoxy group and the other represents a group of the formula: (OCH2CH2)n—NH—X, wherein n is an integer of 1 to 100 and X represents a fluorescent dye and tautomers thereof. Furthermore, the present invention relates to a diagnostic composition comprising the compounds of the invention. The present invention also relates to the use of the compounds of the invention for the preparation of a diagnostic composition for the diagnosis of cancer, the evaluation of cancer biology and/or monitoring of anticancer therapy. In a further aspect, the present invention relates to kits comprising the compounds of the invention.

Abstract: The present invention relates to aminopeptidase N (APN) inhibitor conjugates of formula I wherein W is a —CO— or an —SO2— group and at least one of R1 or R2 represents (OCH2—CH2)n-X, where n is an integer of 1 to 100 and X represents H or a detectable label or a therapeutic, and the other represents an alkoxy group or OH, and wherein R3, R3? and R3? is independently selected from an alkoxy group or (OCH2—CH2)n-X, where n is an integer of 1 to 100 and X represents H or a detectable label or a therapeutic, and R4 is selected from the group comprising: wherein R is an alkyl group. Furthermore, the present invention relates to a diagnostic and/or pharmaceutical composition comprising the conjugate of the invention.

Abstract: The present invention relates to a endothelin receptor antagonist conjugate of the formula (I) wherein R2 is an alkoxy group and one of R1 and R3 represents an alkoxy group and the other represents a group of the formula: (OCH2CH2)n—NH—X, wherein n is an integer of 1 to 100 and X represents a fluorescent dye and tautomers thereof. Furthermore, the present invention relates to a diagnostic composition comprising the compounds of the invention. The present invention also relates to the use of the compounds of the invention for the preparation of a diagnostic composition for the diagnosis of cancer, the evaluation of cancer biology and/or monitoring of anticancer therapy. In a further aspect, the present invention relates to kits comprising the compounds of the invention.

Abstract: Apparatus and methods for cutting through a layer of material. Some embodiments pertain to the removal of an orthopedic cast in a manner that is quiet and generates little or no particulate matter. In yet other embodiments there are a pair of toothed wheels that press down and penetrate into the cast and then split the cast by moving it past a sharp edge. In some embodiments the cutting head is reversible for the cutting of material in either of two opposite directions.

Abstract: The present invention relates to a endothelin receptor antagonist conjugate of the formula (I) wherein R2 is an alkoxy group and one of R1 and R3 represents an alkoxy group and the other represents a group of the formula: (OCH2CH2)n—NH—X, wherein n is an integer of 1 to 100 and X represents a fluorescent dye and tautomers thereof. Furthermore, the present invention relates to a diagnostic composition comprising the compounds of the invention. The present invention also relates to the use of the compounds of the invention for the preparation of a diagnostic composition for the diagnosis of cancer, the evaluation of cancer biology and/or monitoring of anticancer therapy. In a further aspect, the present invention relates to kits comprising the compounds of the invention.

Abstract: A bone plate for internal fixation of a bone fracture includes top and bottom surfaces and an edge. At least one multifunctional hole is provided along the edge and communicates between the top and bottom surfaces and the edge. The hole generally includes a cylindrical portion for closely receiving and guiding a K-wire in a fixed angle. The hole also includes a lateral channel formed into the bottom surface and the edge of the plate such that a curved suture needle and attached suture material may be passed through the hole even when the plate is fixed to the bone. The multifunctional holes may be arranged along the edges of the plate to maintain or modify the stiffness of the plate.

Abstract: A modular bone clamp instrument includes a first elongated arm with a first clamping surface and a second elongated arm with a second clamping surface. A ratchet mechanism is provided between the first elongated arm and the second elongated arm. The ratchet mechanism allows the first elongated arm to move in a first direction, but prevents movement of the first elongated arm in an opposite direction. A squeeze handle is connected to the second elongated arm. The squeeze handle includes a forward handle member and a rear handle member. The rear handle member includes a head with an open chamber. The second elongated arm includes a shoulder that fits in the open chamber. A retention pin extends through the head and shoulder to secure the handle to the second elongated arm. Rotation of the retention pin allows the handle to be released from the second elongated arm.

Abstract: A system for percutaneous fracture repair of a bone is provided. The system includes a plate having a first feature and a second feature. The first feature and the second feature are spaced apart from each other. The plate defines a longitudinal axis of the plate. The system also includes a first attachment component operably associated with the first feature. The first attachment component cooperates with the bone. The system also includes a second attachment component operably associated with the second feature. The second attachment component is percutaneously inserted into the second feature. The second attachment component is operably associated with the plate to provide a compressive force in the bone. The compressive force has a component of the force in the longitudinal axis. The second attachment component is adapted for cooperation with the bone.