Abstract: A device (100) is disclosed for obtaining a breath sample from a patient, The device comprises a mask or mouthpiece (101) for receiving breath from a patient; an outlet (102) through which breath is exhausted from the device (100); a sampler (110); and a sample container (113). The sampler (110) comprises a distal portion configured to protrude into a flow of breath from the mask or mouthpiece (101), and a sampler opening (118) in the distal portion for obtaining a breath sample. The sample container (113) is in communication with the sampler (110) for receiving the breath sample from the sampler (110).

Abstract: The invention relates to a method of diagnosing and a method of treating a cardiorespiratory disease in a subject.

Abstract: The application describes a method of treating chronic obstructive pulmonary disease (COPD) in a patient comprising administering 476 mg of an ST2 antagonist to the patient on Day 1 of a treatment period. The application also describes methods of treating or preventing frequency of moderate to severe exacerbations in a patient having COPD comprising administering an effective amount of an ST2 antagonist to achieve a clinical improvement of at least 10%, at least 20%, at least 21%, at least 22%, at least 25%, at least 30%, at least 35%, at least 40% or at least 45% annualized exacerbation rate reduction than standard of care (SOC).

Abstract: A device (100) is disclosed for obtaining a breath sample from a patient, The device comprises a mask or mouthpiece (101) for receiving breath from a patient; an outlet (102) through which breath is exhausted from the device (100); a sampler (110); and a sample container (113). The sampler (110) comprises a distal portion configured to protrude into a flow of breath from the mask or mouthpiece (101), and a sampler opening (118) in the distal portion for obtaining a breath sample. The sample container (113) is in communication with the sampler (110) for receiving the breath sample from the sampler (110).