Abstract: A balloon catheter includes an inflatable balloon coupled to an outer catheter shaft and an axially translatable nose tip to which the inflatable balloon is coupled. An electrode basket surrounds the balloon and has a plurality of first splines and a plurality of second splines, wherein the plurality of first splines and the plurality of second splines are configured to deploy under inflation of the inflatable balloon and wherein at least some first splines of the plurality of first splines include at least one electrode. An actuator axially translates the nose tip in a longitudinal direction to facilitate the electrode basket moving to a collapsed state when the balloon is deflated and to an expanded state when the balloon is inflated. The actuator moves between an extended position and a retracted position and a lock mechanism locks the actuator in the extended position.

Abstract: A balloon catheter includes an inflatable balloon coupled to an outer catheter shaft and an axially translatable nose tip coupled to the inflatable balloon. An electrode basket surrounds the balloon and has a plurality of first splines and a plurality of second splines. The plurality of splines includes a first reference spline on which a first radiopaque marker is formed, a second reference spline on which a second radiopaque marker is formed and a third reference spline on which a third radiopaque marker is formed, the second radiopaque marker being located a first angular distance in a first direction from the first radiopaque marker and the third radiopaque marker being located the first angular distance in a second direction from the first radiopaque marker, wherein the second radiopaque marker is located proximal to the first radiopaque marker and the third radiopaque marker is located distal to the first radiopaque marker.

Abstract: A multimodality system includes first and second modalities, an optical probe, a detector, and a sheath with a known fluorescence phantom, wherein the phantom would be used for calibration of the catheter providing accurate NIRAF values to the user using the sheath phantom to calibrate an optical probe's measured NIRAF signal to the known fluorescence of the phantom.

Abstract: An ablation balloon catheter includes an outer catheter shaft and an inflatable balloon coupled at a first end to the outer catheter shaft. The catheter includes a translatable nose tip to which a second end of the inflatable balloon is coupled. The catheter has a first electrode basket having a plurality of first splines and a second electrode basket having a plurality of second splines. The second electrode basket is disposed over the first electrode basket and the plurality of first splines are rotationally offset from the plurality of second splines. One or more of the first splines support one or more electrodes and one or more of the second splines support one or more electrodes. The first and second electrode baskets have a collapsed state when the balloon is deflated and a deployed state when the balloon is inflated.

Abstract: A multimodality system includes first and second modalities, an optical probe, a detector, and a sheath with a known fluorescence phantom, wherein the phantom would be used for calibration of the catheter providing accurate NIRAF values to the user using the sheath phantom to calibrate an optical probe's measured NIRAF signal to the known fluorescence of the phantom.

Abstract: A multimodality system includes first and second modalities, an optical probe, a detector, and a phantom with a known fluorescence, wherein the phantom would be used for calibration of the catheter providing accurate NIRAF values to the user using the phantom to calibrate an optical probe's measured NIRAF signal to the known fluorescence of the phantom.

Abstract: In part, the invention relates to a catheter suitable for flushing a vessel. The catheter can include separated lumens and components that improve image data collection. In one embodiment, the catheter includes a catheter wall; a distal portion defining a distal lumen (62), the distal lumen having a first end terminating at the distal end of the catheter and a second end (30) terminating at an exit port in the catheter wall; a proximal portion defining proximal lumen (42), the proximal lumen having a first end terminating at the proximal end of the catheter and a second end terminating at a vent port (34) in the catheter wall; and a valve (50,54) positioned adjacent the vent port, the valve permitting fluid to exit the proximal lumen, but preventing particulate matter from the environment from entering the proximal lumen. In one embodiment, the valve comprises a piston (50) and spring (54) located in the proximal lumen (42).