Abstract: In some examples, a mixing syringe includes a fluid housing defining an internal housing chamber for storing a medical agent, and a fluid outlet. An outer plunger is disposed within the internal housing chamber of the fluid housing. The outer plunger includes an outer barrel defining a barrel cavity and an outer plunger head connected to the outer barrel. The outer plunger is adapted for longitudinal movement within the internal housing chamber of the fluid housing. The outer plunger head defines a flow passage whereby, upon movement of the outer plunger the medical agent passes from the internal housing chamber through the flow passage into the barrel cavity of the outer plunger. An inner plunger is adapted for longitudinal movement relative to the outer plunger to force the medical agent through the flow passage of the outer plunger head for disposition through the fluid outlet of the fluid housing.

Abstract: A mixing nozzle includes at least two individual mixing channels dimensioned to create a turbulent flow effect to facilitate dispersion of the components of a medical agent, such as a liquid embolic composition, during delivery, e.g., to vasculature of a subject. In some examples, the mixing nozzle is configured to be mechanically and fluidically connected to a syringe, a catheter, or both the syringe and the catheter.

Abstract: A single-use syringe assembly is disclosed which includes a syringe body defining a fluid reservoir and including an engagement surface, a plunger assembly including a plunger rod and a sealing member supported on a distal end of the plunger rod, and a releasable member having a proximal end releasably positioned within a sealing member throughbore and a distal end configured to engage the engagement surface of the syringe body when the sealing member is moved to the advanced position. The proximal end of the releasable member being configured to seal the sealing member throughbore. The releasable member is configured such that a force required to remove the distal end of the releasable member from engagement with the engagement surface of the syringe body is greater than the force required to disengage the proximal end of the releasable member from the sealing member throughbore.

Abstract: A mixing nozzle includes at least two individual mixing channels dimensioned to create a turbulent flow effect to facilitate dispersion of the components of a medical agent, such as a liquid embolic composition, during delivery, e.g., to vasculature of a subject. In some examples, the mixing nozzle is configured to be mechanically and fluidically connected to a syringe, a catheter, or both the syringe and the catheter.

Abstract: In some examples, a mixing syringe includes a fluid housing defining an internal housing chamber for storing a medical agent, and a fluid outlet. An outer plunger is disposed within the internal housing chamber of the fluid housing. The outer plunger includes an outer barrel defining a barrel cavity and an outer plunger head connected to the outer barrel. The outer plunger is adapted for longitudinal movement within the internal housing chamber of the fluid housing. The outer plunger head defines a flow passage whereby, upon movement of the outer plunger the medical agent passes from the internal housing chamber through the flow passage into the barrel cavity of the outer plunger. An inner plunger is adapted for longitudinal movement relative to the outer plunger to force the medical agent through the flow passage of the outer plunger head for disposition through the fluid outlet of the fluid housing.

Abstract: A single-use syringe assembly is disclosed which includes a syringe body defining a fluid reservoir and including an engagement surface, a plunger assembly including a plunger rod and a sealing member supported on a distal end of the plunger rod, and a releasable member having a proximal end releasably positioned within a sealing member throughbore and a distal end configured to engage the engagement surface of the syringe body when the sealing member is moved to the advanced position. The proximal end of the releasable member being configured to seal the sealing member throughbore. The releasable member is configured such that a force required to remove the distal end of the releasable member from engagement with the engagement surface of the syringe body is greater than the force required to disengage the proximal end of the releasable member from the sealing member throughbore.