Abstract: Embodiments are directed to systems and methods for two or more cured composite assemblies that are bonded together to form a tubular composite structure, wherein each of the cured composite assemblies do not have a tubular shape. The tubular composite structure may form a spar for an aerodynamic component, for example. The two or more cured composite assemblies may comprise carbon or fiberglass composite materials or a combination of materials. Each of the cured composite assemblies may further comprise axial edges that are configured to be bonded to another of the cured composite assemblies, wherein the axial edges have a sloped shape. An adhesive agent may be applied on the axial edges for bonding two cured composite assemblies. Alternatively, or additionally, one or more fasteners may be used to attach the axial edges of at least two cured composite assemblies.

Abstract: Embodiments are directed to systems and methods for two or more cured composite assemblies that are bonded together to form a tubular composite structure, wherein each of the cured composite assemblies do not have a tubular shape. The tubular composite structure may form a spar for an aerodynamic component, for example. The two or more cured composite assemblies may comprise carbon or fiberglass composite materials or a combination of materials. Each of the cured composite assemblies may further comprise axial edges that are configured to be bonded to another of the cured composite assemblies, wherein the axial edges have a sloped shape. An adhesive agent may be applied on the axial edges for bonding two cured composite assemblies. Alternatively, or additionally, one or more fasteners may be used to attach the axial edges of at least two cured composite assemblies.

Abstract: Embodiments are directed to systems and methods for creating a tubular composite structure. In one embodiment, a device comprises multiple layers of cured composite fabric bonded together to form a tubular composite structure, wherein alternating groups of the multiple layers comprise on-axis fabric and off-axis fabric. The tubular composite structure may form a spar for an aerodynamic component. The composite fabric may comprise one or more of carbon, fiberglass, or other composite materials, or a combination of materials. One or more stacks of the fabric wrap completely around the tubular composite structure, and other stacks of fabric may not wrap completely around the tubular composite structure.

Abstract: Disclosed are compositions and methods for the preparation of RNA libraries for sequencing, gene expression profiling, microarray and other uses and for simplification of the library preparation process. The disclosure provides blocking oligonucleotides which bind to byproduct nucleic acid molecules formed during the ligation of adapters to nucleic acid segments prior to sequencing and inhibit or block amplification of the byproduct nucleic acid molecules in subsequent amplification reactions. Methods for library preparation using blocking oligonucleotides are also provided.

Abstract: A rotorcraft includes a main rotor system coupled to a mast and a rotor assembly. The rotor assembly includes a yoke comprising a rotor coupling, a first damper mount attached to the rotor coupling, a rotor extension configured to couple to the rotor coupling and comprising a second damper mount, a damper coupled to the first and second damper mounts, and a fairing enclosing the damper and the yoke.

Abstract: A link includes an outer composite portion substantially encircling at least two bearing pockets and a central substantially incompressible portion disposed between the at least two bearing pockets.

Abstract: Embodiments are directed to systems and methods for manufacturing composite assemblies comprising laying up composite plies on molds for two or more uncured components, joining the molds for the two or more uncured components to form a tubular body, and curing the joined components simultaneously to create a single composite assembly. The single composite assembly may form a spar for an aerodynamic component. The method may further comprise forming at least one axial edge having a sloped shape on the uncured components and mating the sloped axial edges together when joining the uncured components. The molds for the two or more uncured components may comprise female tools or both female tools and male tools. The two or more cured composite assemblies may comprise one or more of carbon and fiberglass composite materials.

Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.

Abstract: A rotorcraft includes a main rotor system coupled to a mast and a rotor assembly. The rotor assembly includes a yoke comprising a rotor coupling, a first damper mount attached to the rotor coupling, a rotor extension configured to couple to the rotor coupling and comprising a second damper mount, a damper coupled to the first and second damper mounts, and a fairing enclosing the damper and the yoke.

Abstract: A rotorcraft includes a rotor hub coupled to a mast and a plurality of rotor extensions. Each rotor extension is configured to secure a rotor blade to the rotor hub and includes a first connector configured to attach the rotor extension to a rotor blade, a second connector configured to attach the rotor extension to the rotor hub; a shaft disposed between the first and second connectors, and a damper mount attached to the second connector. The rotorcraft also includes a fairing enclosing the damper and at least a portion of the rotor hub.

Abstract: Embodiments are directed to an aerodynamic spinner fairing having a sidewall and one or more airflow intakes in the sidewall. The airflow intakes are closed during a first phase of flight and open during a second phase of flight. The first phase of flight may be an airplane mode for a tiltrotor aircraft, and the second phase of flight may be a helicopter mode for the tiltrotor aircraft. The airflow intakes may comprise an opening in the sidewall, and a door that is configured to move between a first position covering the opening and a second position exposing the opening to external airflow. An actuator coupled to the door may operate to move the door between the first position and the second position. One or more guide vanes within the aerodynamic spinner fairing may be configured to direct air received via the airflow intakes to provide convection cooling.

Abstract: The present invention includes a first barrier layer configured to cover a leading edge of the blade or wing; one or more electrical bus bars disposed on the first barrier layer proximate to and substantially parallel with the leading edge; a ground bus bar disposed on the first barrier layer proximate to and substantially parallel with the leading edge; a second barrier layer disposed over the one or more electrical bus bars and the ground bus bar; one or more heating elements disposed on the second barrier layer, and each heating element electrically connected to one of the electrical bus bars and to the ground bus bar; and a third barrier layer disposed over the one or more heating elements.

Abstract: An afterbody for a rotor blade of a rotorcraft is unitarily formed of a single material of construction. The afterbody includes an upper surface disposed from a lower surface, a concave leading edge connected to the upper surface and the lower surface, and a trailing edge formed at an intersection of the upper surface with the lower surface.

Abstract: Embodiments are directed to an aerodynamic spinner fairing having a sidewall and one or more airflow intakes in the sidewall. The airflow intakes are closed during a first phase of flight and open during a second phase of flight. The first phase of flight may be an airplane mode for a tiltrotor aircraft, and the second phase of flight may be a helicopter mode for the tiltrotor aircraft. The airflow intakes may comprise an opening in the sidewall, and a door that is configured to move between a first position covering the opening and a second position exposing the opening to external airflow. An actuator coupled to the door may operate to move the door between the first position and the second position. One or more guide vanes within the aerodynamic spinner fairing may be configured to direct air received via the airflow intakes to provide convection cooling.

Abstract: Embodiments are directed to systems and methods for creating a tubular composite structure. In one embodiment, a device comprises multiple layers of cured composite fabric bonded together to form a tubular composite structure, wherein alternating groups of the multiple layers comprise on-axis fabric and off-axis fabric. The tubular composite structure may form a spar for an aerodynamic component. The composite fabric may comprise one or more of carbon, fiberglass, or other composite materials, or a combination of materials. One or more stacks of the fabric wrap completely around the tubular composite structure, and other stacks of fabric may not wrap completely around the tubular composite structure.

Abstract: Embodiments are directed to systems and methods for two or more cured composite assemblies that are bonded together to form a tubular composite structure, wherein each of the cured composite assemblies do not have a tubular shape. The tubular composite structure may form a spar for an aerodynamic component, for example. The two or more cured composite assemblies may comprise carbon or fiberglass composite materials or a combination of materials. Each of the cured composite assemblies may further comprise axial edges that are configured to be bonded to another of the cured composite assemblies, wherein the axial edges have a sloped shape. An adhesive agent may be applied on the axial edges for bonding two cured composite assemblies. Alternatively, or additionally, one or more fasteners may be used to attach the axial edges of at least two cured composite assemblies.

Abstract: A bearing assembly for coupling a proprotor blade to a yoke in a proprotor system. The bearing assembly is positionable within an inboard pocket of a blade arm of the yoke. The proprotor system is operable for use on a tiltrotor aircraft having helicopter and airplane flight modes. The bearing assembly includes a centrifugal force bearing and a shear bearing having an inboard beam coupled therebetween. The centrifugal force bearing has a mating surface, a lateral movement constraint feature and at least one radially extending anti-rotation feature. The inboard beam has a mating surface in a contact relationship with the mating surface of the centrifugal force bearing, a lateral movement constraint feature operably associated with the lateral movement constraint feature of the centrifugal force bearing and at least one radially extending anti-rotation feature that corresponds with the at least one radially extending anti-rotation feature of the centrifugal force bearing.

Abstract: A proprotor system for a tiltrotor aircraft includes a yoke having a plurality of blade arms each having an inboard pocket. Each of a plurality of bearing assemblies is disposed at least partially within one of the inboard pockets. Each of a plurality of inboard beams is disposed at least partially between a centrifugal force bearing and a shear bearing of each bearing assembly and has a proprotor blade coupled thereto. Each of a plurality of latch assemblies selectively couples one of the bearing assemblies to the yoke. Each latch assembly is rotatable relative to the yoke between an engaged position wherein the latch assembly is engagable with one of the bearing assemblies to couple the bearing assembly to the yoke and a disengaged position wherein the latch assembly is disengaged from the respective bearing assembly enabling installation and removal of the respective bearing assembly relative to the respective pocket.

Abstract: Modification formats having modified nucleotides are provided for siRNA. Short interfering RNA having modification formats and modified nucleotides provided herein reduce off-target effects in RNA interference of endogenous genes. Further modification formatted siRNAs are demonstrated to be stabilized to nuclease-rich environments. Unexpectedly, increasing or maintaining strand bias, while necessary to maintain potency for endogenous RNA interference, is not sufficient for reducing off-target effects in cell biology assays.

Abstract: A proprotor system for a tiltrotor aircraft having a helicopter flight mode and an airplane flight mode includes a yoke having a plurality of blade arms each having an inboard pocket with a load transfer surface. Each of a plurality of bearing assemblies is disposed at least partially within one of the inboard pockets. Each of a plurality of inboard beams is disposed at least partially between a centrifugal force bearing and a shear bearing of each bearing assembly and has a proprotor blade coupled thereto. Each of a plurality of independent shoes is coupled between one of the centrifugal force bearings and the yoke. Each shoe has a load transfer surface that has a contact relationship with the load transfer surface of the respective inboard pocket forming a centrifugal force load path therebetween.