Abstract: Bone-secured dental arch veneers and methods for fabricating and utilizing the same. The dental arch veneers include a veneer assembly having one or more tooth veneers and a support structure configured to support the tooth veneer(s). The dental arch veneers also include a coupling structure configured to interconnect the veneer assembly to a bone mount that is anchored along a user's maxilla or mandible. The coupling structure also is configured to permit the veneer assembly to be selectively and repeatedly interconnected with and disconnected from the bone mount. The methods include determining a target region within the user's mouth, obtaining a representation of the target region, manipulating the representation to create a desired arrangement of the user's teeth within the target region, determining anchoring positions proximate the target region for anchoring the bone mount, and forming the dental arch veneer based on the anchoring positions and the desired arrangement.

Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: Bone-secured dental arch veneers and methods for fabricating and utilizing the same. The dental arch veneers include a veneer assembly having one or more tooth veneers and a support structure configured to support the tooth veneer(s). The dental arch veneers also include a coupling structure configured to interconnect the veneer assembly to a bone mount that is anchored along a user's maxilla or mandible. The coupling structure also is configured to permit the veneer assembly to be selectively and repeatedly interconnected with and disconnected from the bone mount. The methods include determining a target region within the user's mouth, obtaining a representation of the target region, manipulating the representation to create a desired arrangement of the user's teeth within the target region, determining anchoring positions proximate the target region for anchoring the bone mount, and forming the dental arch veneer based on the anchoring positions and the desired arrangement.

Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

Abstract: Bone-secured dental arch veneers and methods for fabricating and utilizing the same. The dental arch veneers include a veneer assembly having one or more tooth veneers and a support structure configured to support the tooth veneer(s). The dental arch veneers also include a coupling structure configured to interconnect the veneer assembly to a bone mount that is anchored along a user's maxilla or mandible. The coupling structure also is configured to permit the veneer assembly to be selectively and repeatedly interconnected with and disconnected from the bone mount. The methods include determining a target region within the user's mouth, obtaining a representation of the target region, manipulating the representation to create a desired arrangement of the user's teeth within the target region, determining anchoring positions proximate the target region for anchoring the bone mount, and forming the dental arch veneer based on the anchoring positions and the desired arrangement.

Abstract: Bone-secured dental arch veneers and methods for fabricating and utilizing the same. The dental arch veneers include a veneer assembly having one or more tooth veneers and a support structure configured to support the tooth veneer(s). The dental arch veneers also include a coupling structure configured to interconnect the veneer assembly to a bone mount that is anchored along a user's maxilla or mandible. The coupling structure also is configured to permit the veneer assembly to be selectively and repeatedly interconnected with and disconnected from the bone mount. The methods include determining a target region within the user's mouth, obtaining a representation of the target region, manipulating the representation to create a desired arrangement of the user's teeth within the target region, determining anchoring positions proximate the target region for anchoring the bone mount, and forming the dental arch veneer based on the anchoring positions and the desired arrangement.

Abstract: Electromechanical systems, methods, orthodontic brackets, and tools for adjusting orthodontic prescriptions of orthodontic brackets with adjustable archwire passages are disclosed herein. The methods include operatively engaging an orthodontic bracket with an engagement structure of an electronic orthodontic adjustment tool, determining a present orientation of an archwire slot of the orthodontic bracket, displaying a displayed orientation of the archwire slot, and adjusting the orientation of the archwire slot based on the displayed orientation. The orthodontic brackets include a base, a body, a retention structure, a transmitter, and may include an orientation-determining structure. The tools include an engagement structure, an orientation indicator, and may include an orientation-determining structure.

Abstract: Diagnostic communication systems, diagnostic data collection kits, and methods for generating and conveying oral condition data sets and treatment plans. A method of developing a treatment plan to treat an oral condition of a patient includes receiving an oral condition data set, analyzing the oral condition data set, and generating the treatment plan based on the analysis of the oral condition data set. The oral condition data set is at least partially generated by a patient representative utilizing a data collection kit. A data collection kit for generating an oral condition data set includes at least one diagnostic instrument, instructions describing a method of generating at least a portion of the oral condition data set, and/or packaging that contains the at least one diagnostic instrument. The instructions include instructions for delivering the oral condition data set to a service provider and/or a centralized service.

Abstract: Customized temporary veneers that are configured to be temporarily installed in a customer’s mouth and provide a desired oral appearance thereto. The customized temporary veneers include a veneer body configured to extend across at least a portion of a target region of the customer’s mouth and including oral-facing and outward-facing surfaces. The oral-facing surface is configured support the customized temporary veneer relative to the target region by engagement with one or more vestibular surfaces within the target region. A plurality of oral features define at least a portion of the outward-facing surface and are configured to present the desired oral appearance. The methods may include obtaining a representation of the target region, selecting the plurality of oral features, and creating the customized temporary veneer, which includes forming the veneer body, shaping the oral-facing surface based on the representation, and providing the plurality of oral features to the outward-facing surface.

Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: In one aspect, the disclosure relates to methods and compositions for treatment of cancer cachexia. In a further aspect, the composition is a pharmaceutical composition comprising a class I/IIB HDAC inhibitor and an androgen. In a still further aspect, the method of treatment comprises administering a class I/IIB HDAC inhibitor and an androgen to a subject or patient who has been diagnosed as having cancer cachexia. In some aspects, the class I/IIB HDAC inhibitor is a compound known as AR-42.

Abstract: Methods of initiating aligner-based orthodontic treatment of a patient. A method of initiating aligner-based orthodontic treatment of a patient includes recording a dental condition data set, producing one or more dental aligners, and providing the one or more dental aligners to the patient. At least the producing the one or more dental aligners and the providing the one or more dental aligners to the patient are performed at a service provider office while the patient remains at the service provider office.

Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: Adjustable-prescription orthodontic brackets that include a bracket body, a repositionable core that defines an archwire slot, and a core positioning assembly. The bracket body defines a core receptacle into which the core is received and selectively moved within a plurality of prescriptive orientations. The core positioning assembly is selectively transitioned between a disengaged configuration, in which the core positioning assembly permits movement of the core relative to the bracket body within the plurality of prescriptive orientations, and an engaged configuration, in which the core positioning assembly retains the core at the selected prescriptive orientation. The core positioning assembly includes a core clamp with a core engagement surface configured to be selectively engaged with the core, and an actuator configured to selectively secure the core clamp in engagement with the core to retain the core at the selected prescriptive orientation.

Abstract: Orthodontic bracket assemblies with archwire cradles that pivot in correspondence with the rotation of pivot-adjusting drums. The orthodontic bracket assemblies include a pivot-adjusting drum that is configured to be selectively rotated relative to a bracket base about an adjustment axis within a range of operative rotation positions, an archwire cradle that is configured to be selectively pivoted about a cradle axis relative to the bracket base within a range of operative pivot positions, and an adjustment driver that is operatively coupled to the archwire cradle and the pivot-adjusting drum and causes the archwire cradle to pivot relative to the bracket base in correspondence with a rotation of the pivot-adjusting drum. A rotation of the pivot-adjusting drum about the adjustment axis adjusts the torque that is applied to the patient's tooth during prescriptive use of the bracket assembly.

Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: Diagnostic communication systems, diagnostic data collection kits, and methods for generating and conveying oral condition data sets and treatment plans. A method of developing a treatment plan to treat an oral condition of a patient includes receiving an oral condition data set, analyzing the oral condition data set, and generating the treatment plan based on the analysis of the oral condition data set. The oral condition data set is at least partially generated by a patient representative utilizing a data collection kit. A data collection kit for generating an oral condition data set includes at least one diagnostic instrument, instructions describing a method of generating at least a portion of the oral condition data set, and/or packaging that contains the at least one diagnostic instrument. The instructions include instructions for delivering the oral condition data set to a service provider and/or a centralized service.

Abstract: Systems and methods for communicating orthodontic treatment information are disclosed herein. The methods may include methods of delivering an informational resource corresponding to an orthodontic treatment instruction to a patient of an orthodontist, and optionally to a caretaker of the patient and a dentist of the patient. The methods may further include delivering receipt information to the orthodontist and/or the caretaker, wherein the receipt information is indicative of an interaction between the patient and the informational resource. The systems may include electronic devices and interfaces associated with the orthodontist, the patient, the caretaker, and the dentist that may facilitate the communication methods.