Abstract: The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

Abstract: The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected pho-phoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

Abstract: A flexible, open ended microwave cooking tube formed of paper. The paper is provided with a layer of microwave susceptor material such as vacuum deposited metal. The tube is formed of a rectangular blank of the stock comprised of the paper and microwave susceptor material. A pair of opposite, parallel ends of the blank are seamed together and are provided with handle forming holes. In operation, a food item is placed within the tube. During the cooking process, the susceptor material reaches the high temperature required to brown and crispen the food. The seamed, handle portion of the tube, not being provided with susceptor material, remains relatively unheated and is hence less dangerous to the user when the tube and food are removed from the microwave oven. The tube can be formed from a continuous length of the paper/susceptor stock and wound into a roll. Short lengths of the tube can then be cut from the roll to provide individual containers for microwave cooking.