Abstract: The present disclosure relates to a spinal implant or spacer that addresses the variation in anatomy of vertebrae along the spine by having inferior and superior surface angle and convexity variations that are adapted to address the differences in lordosis and endplate surface convexity of the spine. The difference between the convexity of the superior and inferior surface of the spacer increases as the lordotic angle of the spacer increases. The spacers described herein thus provide overall improved fit into vertebral disc space and in some embodiments are even used in the absence of fusion for a prolonged period. The vertebral spacers described herein in some embodiments are used with supplemental internal fixation systems, such as an anchor plate. The interior of the spacer has channels and undercuts to increase graft volume and retention, support bony ingrowth, and bony stability for better secondary and tertiary stabilization.

Abstract: The present disclosure relates to a spinal implant or spacer that addresses the variation in anatomy of vertebrae along the spine by having inferior and superior surface angle and convexity variations that are adapted to address the differences in lordosis and endplate surface convexity of the spine. The difference between the convexity of the superior and inferior surface of the spacer increases as the lordotic angle of the spacer increases. The spacers described herein thus provide overall improved fit into vertebral disc space and in some embodiments are even used in the absence of fusion for a prolonged period. The vertebral spacers described herein in some embodiments are used with supplemental internal fixation systems, such as an anchor plate. The interior of the spacer has channels and undercuts to increase graft volume and retention, support bony ingrowth, and bony stability for better secondary and tertiary stabilization.

Abstract: A portable litter with an integrated IV pole comprising: a frame having a handle section; a storage cavity defined in the handle section; a handle grip extendably attached to the handle section that can be retracted into the storage cavity or extended out of the storage cavity; an end cap removably secured to the handle grip having an IV pole retaining assembly; an IV pole having a standard that can be secured to the end cap by the retaining assembly, received in an opening defined in the handle grip and received in the storage cavity when the IV pole is in a collapsed configuration; and, a support arm rotatably attached to the standard that is parallel to the standard when the IV pole is in a collapsed configuration and rotated generally perpendicular to the standard when the IV pole is in an operational position.

Abstract: The intervertebral implant is in the form of a three-dimensional structure (10) comprising (a) a top side (1) and an underside (2) which are designed to rest against the end plates of two adjacent vertebras, (b) a left side face (3) and a right side face (4), (c) a front face (5) and a rear face (6), (d) a horizontal center plane situated between the top side (1) and the underside (2), (e) a vertical center plane (8) situated between the left side face (3) and the right side face (8) and (f) a plurality of boreholes (9) passing through the implant structure (10) that are designed to receive longitudinal affixation elements (20), the axes (19) of said elements intersecting the horizontal center plane (7). At least one of the boreholes (9) is designed in a manner that the affixation element (10) received in it can be rigidly connected to the intervertebral implant. Said connection is implemented using a thread or by matching conical surfaces.

Abstract: The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

Abstract: The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I wherein R1, R2, R3, R5, R6 and R7 are independently X3R where R is selected from the group consisting of H, halo; optionally substituted saccharide, aliphatic, cycloalkyl, heterocycloalkyl, aryl and heteroaryl; —P(O)(ORa)(ORb) and —NRaRb, where Ra and Rb are independently H, optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; X1, X2 and X3 are independently —C(O)O—, —OC(O)—, —C(O)NH—, —NHC(O)—, —OC(O)NH—, —NHC(O)O—, —OS(O)y—, —S(O)y—, —O—, —NHC(O)—, —NHC(O)O—, —S(O)2NH—, a bond or absent; where y is an integer from 0 to 3; and R4 and R8 are independently H, (?O); hydroxy; or optionally substituted saccharide, aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; or —P(O)(ORa)(ORb) or —NRaRb, where Ra and Rb are independently H, or optionally substituted aliphatic, cycloalkyl or heterocycloalkyl, aryl or heteroaryl; or a prod

Abstract: The intervertebral implant is in the form of a three-dimensional structure (10) comprising (a) a top side (1) and an underside (2) which are designed to rest against the end plates of two adjacent vertebras, (b) a left side face (3) and a right side face (4), (c) a front face (5) and a rear face (6), (d) a horizontal center plane situated between the top side (1) and the underside (2), (e) a vertical center plane (8) situated between the left side face (3) and the right side face (8) and (f) a plurality of boreholes (9) passing through the implant structure (10) that are designed to receive longitudinal affixation elements (20), the axes (19) of said elements intersecting the horizontal center plane (7). At least one of the boreholes (9) is designed in a manner that the affixation element (10) received in it can be rigidly connected to the intervertebral implant. Said connection is implemented using a thread or by matching conical surfaces.