Abstract: Disclosed herein are methods and systems to predict and quantify a patient's burden when participating in a clinical trial. A method includes gathering data associated with pervious participants and their burden and experiences when participating in clinical trials. The method also includes executing data clean-up protocols to quantify and standardize the previous participants' experiences and burden. The method then includes training one or more computer models to identify connections between participants and their unique attributes in light of their standardized burden and to predict a patient burden score for a new patient participating in a new clinical trial.

Abstract: A medical connector includes a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end, a helical thread extending radially outward from a surface of the sidewall and comprising a crest portion, flank portions, and a root portion with the flank portions connecting the root portion to the crest portion, and at least one micro-thread extending radially outward from the surface of the sidewall. At least a portion of the micro-thread is spaced apart from the helical thread.

Abstract: A medical connector includes a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end, a helical thread extending radially outward from a surface of the sidewall and comprising a crest portion, flank portions, and a root portion with the flank portions connecting the root portion to the crest portion, and at least one micro-thread extending radially outward from the surface of the sidewall. At least a portion of the micro-thread is spaced apart from the helical thread.

Abstract: A medical connector includes a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end, a helical thread extending radially outward from a surface of the sidewall and comprising a crest portion, flank portions, and a root portion with the flank portions connecting the root portion to the crest portion, and at least one micro-thread extending radially outward from the surface of the sidewall. At least a portion of the micro-thread is spaced apart from the helical thread.

Abstract: A medical connector includes a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end. The medical connector further includes a helical thread extending radially outward from a surface of the sidewall and at least one protrusion extending radially outward from a surface of the sidewall. The at least one protrusion has a first side and a second side. A radial height of the at least one protrusion from the surface of the sidewall tapers circumferentially from the first side of the at least one protrusion to the second side of the at least one protrusion.

Abstract: The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying. The present invention also relates to an assay for determining platelet adhesion and aggregation using microfluidic flow cell system having a shear flow. The assay assesses labeled whole blood samples having reconstituted plasma having spray dried plasma and a reconstitution solution; platelets; and red blood cells. After inducing a shear flow under conditions suitable for clot formation, coverage area of the platelets, intensity of the platelets, morphology, or a combination thereof is detected to determine platelet accumulation (e.g., platelet adhesion and aggregation).

Abstract: The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying. The present invention also relates to an assay for determining platelet adhesion and aggregation using microfluidic flow cell system having a shear flow. The assay assesses labeled whole blood samples having reconstituted plasma having spray dried plasma and a reconstitution solution; platelets; and red blood cells. After inducing a shear flow under conditions suitable for clot formation, coverage area of the platelets, intensity of the platelets, morphology, or a combination thereof is detected to determine platelet accumulation (e.g., platelet adhesion and aggregation).

Abstract: A medical connector includes a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end, a helical thread extending radially outward from a surface of the sidewall and comprising a crest portion, flank portions, and a root portion with the flank portions connecting the root portion to the crest portion, and at least one micro-thread extending radially outward from the surface of the sidewall. At least a portion of the micro-thread is spaced apart from the helical thread.

Abstract: A medical connector includes a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end. The medical connector further includes a helical thread extending radially outward from a surface of the sidewall and at least one protrusion extending radially outward from a surface of the sidewall. The at least one protrusion has a first side and a second side. A radial height of the at least one protrusion from the surface of the sidewall tapers circumferentially from the first side of the at least one protrusion to the second side of the at least one protrusion.

Abstract: A system for improving a logic circuit may include a processor, and a logic circuit analyzer in communication with the processor to model a plurality of nets. The system may also include an interface in communication with the logic circuit analyzer to select a target slack-value for each one of the plurality of nets. The logic circuit analyzer may determine a slack-value for each net. In addition, the logic circuit analyzer may selectively reduce resistive-capacitive delay for each net respectively if the determined slack-value is less than the target slack-value for each respective net.

Abstract: A method and apparatus for laser drilling a vibrating workpiece. A laser is mounted to a stationary frame. A separate machine having a separate machine frame has a spherical lens mounted to the top of the machine frame in proximity to a workpiece engaged by the machine. The vibrations of the machine caused by operation are transmitted to the lens and workpiece. A laser beam emitted by the laser is transmitted thought the lens and focused on the workpiece. The apparatus and method provides for precisely drilled and located holes or openings in the workpiece.

Abstract: A system for improving a logic circuit may include a processor, and a logic circuit analyzer in communication with the processor to model a plurality of nets. The system may also include an interface in communication with the logic circuit analyzer to select a target slack-value for each one of the plurality of nets. The logic circuit analyzer may determine a slack-value for each net. In addition, the logic circuit analyzer may selectively reduce resistive-capacitive delay for each net respectively if the determined slack-value is less than the target slack-value for each respective net.

Abstract: The invention relates to layout of circuit components, including determining the interconnections, buffers, or path nets between circuit blocks or circuit components and input/output bonding pads. This is accomplished by a method and program product that optimizes timing comprising. Wiring layout and buffer insertion is accomplished by setting all wires in the design to an initial best possible value, inserting buffers in longest nets of wires of the design, and degrading the resulting nets. This is accomplished by a wire sizing routine which takes the nets and degrades them accordingly. This degrading is done through a combination of one or more of knocking the wires down to lower levels and reducing their thickness. The amount of degradation is dependent on the final slack.